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Protein Overview: SLK19

General Information:
Name(s) found: SLK19 / YOR195W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 821 amino acids

    Gene Ontology:
    Cellular Component: spindle [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    kinetochore [IDALink to PubMed article]
    Biological Process: mitotic spindle organization in nucleus [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEVPTTPVR LILGQAQQRE QNSENCSQER NPRTFNSEPD SSFNSPGSSQ FVIHPHEPLE  60
   61 KEKDEKQDLD RSIDYGRSSA LNNKNNANPL ENIDINKMFD DKKSDSGTND DKGGASTSDK 120
  121 HVLALNYSPI RVEMNSSEKR SDKNVDVDEN DKEGSHINKK LKLQLESVPD LKQSSTKDII 180
  181 NDKEEIMSSP MAIDMIETNI SPNKFIINDG VERNDSFNIN TDTLKLENDI NEKQQEEDFI 240
  241 KSNSNNVVNI DNAYKEKEDE ENDITNSHIN RLTPLYETSA RESNSNEEGR NDYDDDNQLD 300
  301 IRHDNFQIVA KRNEELTDQI YHLNQMLNSL ISKNESLSFQ YEKLNKNHQL LIDLTNEKLD 360
  361 KLNTERESDI AKVEKFKKRI KELNTEIKVL NSNQKILQEK FDASITEVNH IKGEHENTVN 420
  421 TLQQNEKILN DKNVELENMK AELKGNNDKL SEYETTLNDL NSRIVQLNDK IESTDIVLKS 480
  481 KENELDNLKL SLKETLSISK DFNDSDLIGQ INELISTKNN LQQKMDDLNN LNDDNLKVVQ 540
  541 DKLIKNEETL KLKEAEIDSL NSEMDELKKQ ITSKDDEFKM WQSKYETVED EAKIRNAEVT 600
  601 ELNGDIEDLK ESKLHLEETI TELENKVHKL ENECELEKQK FEKTSLELES LQLKNSNIQA 660
  661 EHIKELENLH ENLISLQNEL KISSDRITTL TKENEVLMEQ NNNNNNSVTL SNDQKDRDDE 720
  721 KIKSLGKQVQ DWKEKYEAKE KDTNKRLKLL AEDLYIQYSS KHEQKVKLLK KGYENKYQNK 780
  781 FDQLNLENKT LSEEIEQLNK QLSSEREEKQ ELLKLLENEK K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AIM3 BAR1 COA4 GYL1 GYP5 HNT1 KIN2 MEF2 NCP1 PCL10 PRP28 RVS161 RVS167 SAE2 SLK19 TIM21 VPS15
    View Details Qiu et al. (2008) BIK1 BUB1 CIK1 KAR3 NUF2 SLK19 SPC110 STU1 STU2 TID3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run IPL1 No Comments Cheeseman IM, et al. (2002)
    View Run SLK19 No Comments Cheeseman IM, et al. (2002)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLK19 Sundin BA, et al. (2004)
    View Data SLK19 Sundin BA, et al. (2004)
    View Data SLK19 and SPC42 Huh WK, et al. (2003)
    View Data SLK19 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..458] PSI-BLAST 33.69897 Heavy meromyosin subfragment
    2 View Details [459..552] PSI-BLAST 11.09691 Tropomyosin
    3 View Details [553..655] PSI-BLAST 11.09691 Tropomyosin
    4 View Details [656..821] MSA 14.223995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.03440533979709 bayes_pls_golite062009
  • DNA binding
    		•  3.65811636468179 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.60537549931501 bayes_pls_golite062009
  • transcription factor activity
    		•  3.22337383289465 bayes_pls_golite062009
  • binding
    		•  2.87991790206998 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.1457670954804 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.87665013586148 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.77682537012597 bayes_pls_golite062009
  • actin binding
    		•  1.48871115327078 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.34516545338213 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19647956161774 bayes_pls_golite062009
  • protein binding
    		•  1.03780839342631 bayes_pls_golite062009
  • transcription factor binding
    		•  0.86100194020002 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.57258935872519 bayes_pls_golite062009
  • chromatin binding
    		•  0.400813784720149 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.33597123085446 bayes_pls_golite062009
  • actin filament binding
    		•  0.26311995282891 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.09491254824772 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle