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View Structure Prediction Details

Protein: SLK19
Organism: Saccharomyces cerevisiae
Length: 821 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLK19.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
7.0E-88 [3..818] [1070..1911]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-87 [3..818] [87..928]
gi|45383668, gi|... - gi|9800486|gb|AAF99314.1|AF272033_1 fast myosin heavy chain isoform 2 [Gallus gallus], gi|45383668|r...
7.0E-87 [3..818] [1076..1917]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
2.0E-86 [3..818] [1071..1912]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
3.0E-86 [3..818] [1072..1913]

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Predicted Domain #1
Region A:
Residues: [1-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEVPTTPVR LILGQAQQRE QNSENCSQER NPRTFNSEPD SSFNSPGSSQ FVIHPHEPLE  60
   61 KEKDEKQDLD RSIDYGRSSA LNNKNNANPL ENIDINKMFD DKKSDSGTND DKGGASTSDK 120
  121 HVLALNYSPI RVEMNSSEKR SDKNVDVDEN DKEGSHINKK LKLQLESVPD LKQSSTKDII 180
  181 NDKEEIMSSP MAIDMIETNI SPNKFIINDG VERNDSFNIN TDTLKLENDI NEKQQEEDFI 240
  241 KSNSNNVVNI DNAYKEKEDE ENDITNSHIN RLTPLYETSA RESNSNEEGR NDYDDDNQLD 300
  301 IRHDNFQIVA KRNEELTDQI YHLNQMLNSL ISKNESLSFQ YEKLNKNHQL LIDLTNEKLD 360
  361 KLNTERESDI AKVEKFKKRI KELNTEIKVL NSNQKILQEK FDASITEVNH IKGEHENTVN 420
  421 TLQQNEKILN DKNVELENMK AELKGNNDKL SEYETTLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [459-552]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLNSRIVQLN DKIESTDIVL KSKENELDNL KLSLKETLSI SKDFNDSDLI GQINELISTK  60
   61 NNLQQKMDDL NNLNDDNLKV VQDKLIKNEE TLKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.09691
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [553-655]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEAEIDSLNS EMDELKKQIT SKDDEFKMWQ SKYETVEDEA KIRNAEVTEL NGDIEDLKES  60
   61 KLHLEETITE LENKVHKLEN ECELEKQKFE KTSLELESLQ LKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.09691
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.03440533979709 bayes_pls_golite062009
DNA binding 3.65811636468179 bayes_pls_golite062009
nucleic acid binding 3.60537549931501 bayes_pls_golite062009
transcription factor activity 3.22337383289465 bayes_pls_golite062009
binding 2.87991790206998 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
sequence-specific DNA binding 1.87665013586148 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.77682537012597 bayes_pls_golite062009
actin binding 1.48871115327078 bayes_pls_golite062009
transcription repressor activity 1.34516545338213 bayes_pls_golite062009
transcription activator activity 1.19647956161774 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
transcription factor binding 0.86100194020002 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.57258935872519 bayes_pls_golite062009
chromatin binding 0.400813784720149 bayes_pls_golite062009
transcription cofactor activity 0.33597123085446 bayes_pls_golite062009
actin filament binding 0.26311995282891 bayes_pls_golite062009
centromeric DNA binding 0.09491254824772 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [656-821]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNIQAEHIKE LENLHENLIS LQNELKISSD RITTLTKENE VLMEQNNNNN NSVTLSNDQK  60
   61 DRDDEKIKSL GKQVQDWKEK YEAKEKDTNK RLKLLAEDLY IQYSSKHEQK VKLLKKGYEN 120
  121 KYQNKFDQLN LENKTLSEEI EQLNKQLSSE REEKQELLKL LENEKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle