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Protein Overview: ELP2

General Information:
Name(s) found: ELP2 / YGR200C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 788 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    transcription elongation factor complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein urmylation [IMPLink to PubMed article]
    tRNA modification [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVECITPEAI FIGANKQTQV SDIHKVKKIV AFGAGKTIAL WDPIEPNNKG VYATLKGHEA  60
   61 EVTCVRFVPD SDFMVSASED HHVKIWKFTD YSHLQCIQTI QHYSKTIVAL SALPSLISVG 120
  121 CADGTISIWR QNIQNDEFGL AHEFTIKKGF FYPLCLSLSK VEEKKYLLAI GGTNVNVFIA 180
  181 SFILSDSGIE KCRVVAELEG HEDWVKSLAF RHQETPGDYL LCSGSQDRYI RLWRIRINDL 240
  241 IDDSEEDSKK LTLLSNKQYK FQIDDELRVG INFEALIMGH DDWISSLQWH ESRLQLLAAT 300
  301 ADTSLMVWEP DETSGIWVCS LRLGEMSSKG ASTATGSSGG FWSCLWFTHE RMDFFLTNGK 360
  361 TGSWRMWATK DNIICDQRLG ISGATKDVTD IAWSPSGEYL LATSLDQTTR LFAPWIYDAS 420
  421 GRKREIATWH EFSRPQIHGY DMICVETVTD TRFVSGGDEK ILRSFDLPKG VAGMLQKFVG 480
  481 IQFEEKSEMP DSATVPVLGL SNKAGEDDAN EDDEEEEGGN KETPDITDPL SLLECPPMED 540
  541 QLQRHLLWPE VEKLYGHGFE ITCLDISPDQ KLIASACRSN NVQNAVIRIF STENWLEIKP 600
  601 ALPFHSLTIT RLKFSKDGKF LLSVCRDRKW ALWERNMEDN TFELRFKNEK PHTRIIWDAD 660
  661 WAPLEFGNVF VTASRDKTVK VWRHQKEPAD DYVLEASIKH TKAVTAISIH DSMIREKILI 720
  721 SVGLENGEIY LYSYTLGKFE LITQLNEDIT PADKITRLRW SHLKRNGKLF LGVGSSDLST 780
  781 RIYSLAYE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELP2 ELP3 ELP4 ELP6 IKI1 IKI3 YIL096C
    View Details Krogan NJ, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3 KTI12 YIL096C
    View Details Gavin AC, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Gavin AC, et al. (2002) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Ho Y, et al. (2002) ELP2 ELP3 IKI3 NIS1 RSF2
    View Details Qiu et al. (2008) CHD1 ELP2 ELP3 ELP4 ELP6 IKI1 IKI3 RTF1 SPT16

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ELP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..542] PSI-BLAST 6.522879 Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
    2 View Details [543..634] PSI-BLAST 90.927757 beta1-subunit of the signal-transducing G protein heterotrimer
    3 View Details [635..711] PSI-BLAST 136.9897 Tup1, C-terminal domain
    4 View Details [712..788] MSA 1.456995 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • actin binding
    		•  3.31804728298431 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.13054264433898 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  3.00646122159505 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
    		• 2.40807791198019 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.17819869145391 bayes_pls_golite062009
  • dynactin binding
    		•  1.85146647785657 bayes_pls_golite062009
  • snoRNA binding
    		•  1.76991421703041 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • actin filament binding
    		•  1.5197243426595 bayes_pls_golite062009
  • RNA binding
    		•  1.50295916950465 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.4866444894826 bayes_pls_golite062009
  • hydrolase activity
    		•  1.36960741137363 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.21305848427711 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • ligase activity
    		•  0.93058496790047 bayes_pls_golite062009
  • transporter activity
    		•  0.692270256454453 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.367729389382533 bayes_pls_golite062009
  • signal transducer activity
    		•  0.367729389382533 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.121183207943714 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle