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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ntg1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • FET3
  • plasma membrane
  • high-affinity iron ion transport
  • response to copper ion
  • iron ion transmembrane transporter activity
  • ferroxidase activity
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • NTG1
  • nucleus
  • mitochondrion
  • DNA repair
  • base-excision repair
  • base-excision repair, AP site formation
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
  • DNA-(apurinic or apyrimidinic site) lyase activity
  • oxidized purine base lesion DNA N-glycosylase activity
  • PRB1
  • fungal-type vacuole lumen
  • fungal-type vacuole
  • cellular response to starvation
  • sporulation resulting in formation of a cellular spore
  • vacuolar protein catabolic process
  • serine-type endopeptidase activity
  • RFC2
  • DNA replication factor C complex
  • sister chromatid cohesion
  • cell cycle checkpoint
  • leading strand elongation
  • mismatch repair
  • DNA clamp loader activity
  • purine nucleotide binding
  • RPC40
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • TIF34
  • multi-eIF complex
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 3 complex 4.7546E-5 10 7 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 1.8923E-3 10 42 2 6292
    response to stimulus 3.9288E-3 10 766 5 6292
    base-excision repair, AP site formation 4.7611E-3 10 3 1 6292
    response to stress 5.4959E-3 10 497 4 6292
    high-affinity iron ion transport 6.3436E-3 10 4 1 6292
    response to copper ion 6.3436E-3 10 4 1 6292
    isocitrate metabolic process 7.9239E-3 10 5 1 6292
    iron ion transmembrane transport 7.9239E-3 10 5 1 6292
    cellular response to stress 9.1321E-3 10 290 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    purine nucleotide binding 2.8897E-3 10 52 2 6292
    oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 3.1764E-3 10 2 1 6292
    oxidized pyrimidine base lesion DNA N-glycosylase activity 3.1764E-3 10 2 1 6292
    ferroxidase activity 3.1764E-3 10 2 1 6292
    oxidized purine base lesion DNA N-glycosylase activity 3.1764E-3 10 2 1 6292
    isocitrate dehydrogenase (NAD+) activity 3.1764E-3 10 2 1 6292
    nucleotide binding 3.7066E-3 10 59 2 6292
    chaperone activator activity 4.7611E-3 10 3 1 6292
    oxidized base lesion DNA N-glycosylase activity 4.7611E-3 10 3 1 6292
    serine-type endopeptidase activity 6.3436E-3 10 4 1 6292
    DNA-(apurinic or apyrimidinic site) lyase activity 7.9239E-3 10 5 1 6292
    DNA N-glycosylase activity 7.9239E-3 10 5 1 6292
    isocitrate dehydrogenase activity 7.9239E-3 10 5 1 6292
    serine-type peptidase activity 9.5019E-3 10 6 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle