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Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Catalysis of the breakage of a carbon-oxygen bond. Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: oxidized purine base lesion DNA N-glycosylase activity
Acc: GO:0008534
Aspect: Molecular Function
Desc: Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
Synonyms:
  • formamidopyrimidine-DNA glycosylase activity
  • bifunctional DNA glycosylase activity
  • purine-specific oxidized base lesion DNA N-glycosylase activity
  • DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]
  • fapy-DNA glycosylase activity
  • DNA-formamidopyrimidine glycosylase activity
  • 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity
  • deoxyribonucleate glycosidase activity
  • Fpg protein
  • DNA glycosylase/AP-lyase activity
  • 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity
  • DNA glycosylase/beta-lyase activity
  • GO:0003907
  • 8-oxoguanine DNA glycosylase activity
Proteins in PDR annotated with:
   This term: 19 [Search]
   Term or descendants: 19 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008534 - oxidized purine base lesion DNA N-glycosylase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle