YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. Catalysis of the breakage of a carbon-oxygen bond. Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA-(apurinic or apyrimidinic site) lyase activity
Acc: GO:0003906
Aspect: Molecular Function
Desc: Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Synonyms:
  • Phage-T4 UV endonuclease activity
  • Micrococcus luteus UV endonuclease activity
  • endodeoxyribonuclease (apurinic or apyrimidinic) activity
  • phage-T4 UV endonuclease
  • AP endonuclease class I activity
  • X-ray endonuclease III
  • Phage-T(4) UV endonuclease activity
  • AP site-DNA 5'-phosphomonoester-lyase activity
  • deoxyribonuclease (apurinic or apyrimidinic) activity
  • endonuclease VIII activity
  • E. coli endonuclease III
  • DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity
  • micrococcus luteus UV endonuclease
  • AP lyase activity
  • E. coli endonuclease III activity
Proteins in PDR annotated with:
   This term: 48 [Search]
   Term or descendants: 66 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle