YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DPB2
  • replication fork
  • nucleus
  • cytoplasm
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA binding
  • nucleotidyltransferase activity
  • DNA-directed DNA polymerase activity
  • double-stranded DNA binding
  • transferase activity
  • DPB3
  • replication fork
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • chromatin silencing at telomere
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • double-stranded DNA binding
  • transferase activity
  • DPB4
  • chromatin accessibility complex
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • chromatin silencing at telomere
  • DNA binding
  • nucleotidyltransferase activity
  • DNA-directed DNA polymerase activity
  • double-stranded DNA binding
  • transferase activity
  • INM1
  • nucleus
  • cytoplasm
  • inositol phosphate dephosphorylation
  • inositol-1(or 4)-monophosphatase activity
  • MBA1
  • mitochondrion
  • mitochondrial inner membrane
  • inner mitochondrial membrane organization
  • aerobic respiration
  • molecular_function
  • MCM2
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • POL2
  • replication fork
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA synthesis involved in DNA repair
  • chromatin silencing at telomere
  • nucleotide binding
  • nucleic acid binding
  • DNA binding
  • zinc ion binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • metal ion binding
  • double-stranded DNA binding
  • transferase activity
  • RPN4
  • proteasome regulatory particle
  • positive regulation of DNA repair
  • G2/M transition of mitotic cell cycle
  • response to arsenic
  • telomere maintenance
  • positive regulation of protein catabolic process
  • positive regulation of transcription
  • transcription factor activity
  • transcription activator activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    epsilon DNA polymerase complex 5.3619E-12 8 5 4 6292
    DNA polymerase complex 2.2463E-10 8 10 4 6292
    protein-DNA complex 2.7991E-9 8 57 5 6292
    replisome 3.2598E-9 8 18 4 6292
    nuclear replisome 3.2598E-9 8 18 4 6292
    nuclear replication fork 5.1561E-9 8 20 4 6292
    nucleotide-excision repair complex 6.3661E-9 8 21 4 6292
    replication fork 1.1779E-7 8 42 4 6292
    nuclear chromosome part 1.2398E-6 8 190 5 6292
    nuclear chromosome 3.0646E-6 8 228 5 6292
    chromosomal part 3.7117E-6 8 237 5 6292
    chromosome 7.5944E-6 8 274 5 6292
    protein complex 6.9038E-4 8 1137 6 6292
    non-membrane-bounded organelle 3.0487E-3 8 959 5 6292
    intracellular non-membrane-bounded organelle 3.0487E-3 8 959 5 6292
    chromatin accessibility complex 5.0773E-3 8 4 1 6292
    macromolecular complex 5.1894E-3 8 1635 6 6292
    nuclear part 5.7545E-3 8 1103 5 6292
    MCM complex 8.8705E-3 8 7 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    leading strand elongation 1.4564E-9 8 15 4 6292
    lagging strand elongation 3.2598E-9 8 18 4 6292
    DNA-dependent DNA replication 1.8058E-8 8 82 5 6292
    DNA strand elongation 3.3298E-8 8 31 4 6292
    DNA strand elongation involved in DNA replication 3.3298E-8 8 31 4 6292
    DNA replication 1.4066E-7 8 123 5 6292
    mismatch repair 3.8912E-6 8 27 3 6292
    nucleotide-excision repair 1.1149E-5 8 38 3 6292
    DNA metabolic process 1.4992E-5 8 585 6 6292
    chromatin silencing at telomere 3.4321E-5 8 55 3 6292
    DNA repair 5.3445E-5 8 192 4 6292
    response to DNA damage stimulus 1.1994E-4 8 236 4 6292
    negative regulation of gene expression, epigenetic 2.059E-4 8 100 3 6292
    gene silencing 2.059E-4 8 100 3 6292
    regulation of gene expression, epigenetic 2.059E-4 8 100 3 6292
    chromatin silencing 2.059E-4 8 100 3 6292
    cellular response to stress 2.671E-4 8 290 4 6292
    cellular response to stimulus 7.4705E-4 8 379 4 6292
    negative regulation of transcription, DNA-dependent 7.7844E-4 8 157 3 6292
    regulation of transcription 7.8534E-4 8 384 4 6292
    negative regulation of RNA metabolic process 7.9303E-4 8 158 3 6292
    cellular macromolecule biosynthetic process 8.7999E-4 8 1187 6 6292
    negative regulation of transcription 8.8426E-4 8 164 3 6292
    negative regulation of gene expression 8.8426E-4 8 164 3 6292
    macromolecule biosynthetic process 8.8836E-4 8 1189 6 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.055E-3 8 415 4 6292
    regulation of nitrogen compound metabolic process 1.0647E-3 8 416 4 6292
    negative regulation of macromolecule biosynthetic process 1.0685E-3 8 175 3 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.1598E-3 8 180 3 6292
    negative regulation of nitrogen compound metabolic process 1.1598E-3 8 180 3 6292
    regulation of DNA repair 1.2715E-3 8 1 1 6292
    positive regulation of DNA repair 1.2715E-3 8 1 1 6292
    positive regulation of response to stimulus 1.2715E-3 8 1 1 6292
    negative regulation of biosynthetic process 1.3363E-3 8 189 3 6292
    negative regulation of cellular biosynthetic process 1.3363E-3 8 189 3 6292
    regulation of gene expression 1.374E-3 8 445 4 6292
    negative regulation of macromolecule metabolic process 1.3988E-3 8 192 3 6292
    regulation of macromolecule biosynthetic process 1.5066E-3 8 456 4 6292
    regulation of cellular biosynthetic process 1.7154E-3 8 472 4 6292
    regulation of biosynthetic process 1.7291E-3 8 473 4 6292
    negative regulation of cellular metabolic process 1.788E-3 8 209 3 6292
    negative regulation of metabolic process 1.8128E-3 8 210 3 6292
    regulation of macromolecule metabolic process 1.9441E-3 8 488 4 6292
    response to stress 2.0819E-3 8 497 4 6292
    nucleic acid metabolic process 2.3473E-3 8 1415 6 6292
    regulation of primary metabolic process 2.361E-3 8 514 4 6292
    regulation of cellular response to stress 2.5415E-3 8 2 1 6292
    inositol phosphate dephosphorylation 2.5415E-3 8 2 1 6292
    phosphorylated carbohydrate dephosphorylation 2.5415E-3 8 2 1 6292
    regulation of cellular metabolic process 2.7603E-3 8 536 4 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    regulation of metabolic process 2.9768E-3 8 547 4 6292
    negative regulation of cellular process 2.9919E-3 8 250 3 6292
    transcription 3.0791E-3 8 552 4 6292
    negative regulation of biological process 3.0957E-3 8 253 3 6292
    regulation of response to stress 3.8101E-3 8 3 1 6292
    positive regulation of protein catabolic process 3.8101E-3 8 3 1 6292
    positive regulation of DNA metabolic process 3.8101E-3 8 3 1 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1016E-3 8 1566 6 6292
    cellular biosynthetic process 4.1159E-3 8 1567 6 6292
    biosynthetic process 4.6438E-3 8 1602 6 6292
    DNA synthesis involved in DNA repair 5.0773E-3 8 4 1 6292
    cellular nitrogen compound metabolic process 7.9712E-3 8 1770 6 6292
    regulation of transcription, DNA-dependent 8.2536E-3 8 358 3 6292
    nitrogen compound metabolic process 8.4927E-3 8 1791 6 6292
    regulation of RNA metabolic process 8.5789E-3 8 363 3 6292
    positive regulation of catabolic process 8.8705E-3 8 7 1 6292
    regulation of protein catabolic process 8.8705E-3 8 7 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    double-stranded DNA binding 9.4092E-9 8 23 4 6292
    structure-specific DNA binding 1.4271E-7 8 44 4 6292
    DNA binding 5.4328E-6 8 256 5 6292
    DNA-directed DNA polymerase activity 5.867E-6 8 110 4 6292
    DNA polymerase activity 7.0076E-6 8 115 4 6292
    nucleotidyltransferase activity 3.1578E-5 8 168 4 6292
    nucleic acid binding 5.58E-4 8 666 5 6292
    transferase activity, transferring phosphorus-containing groups 1.1041E-3 8 420 4 6292
    binding 1.4278E-3 8 1294 6 6292
    inositol-1(or 4)-monophosphatase activity 2.5415E-3 8 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle