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Protein Overview: SEC8

General Information:
Name(s) found: SEC8 / YPR055W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1065 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [TASLink to PubMed article]
    cellular bud tip [IDALink to PubMed article]
    site of polarized growth [IDALink to PubMed article]
    exocyst [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: vesicle fusion [TASLink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    vesicle docking during exocytosis [TASLink to PubMed article]
    Golgi to plasma membrane transport [TASLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYLKPAQKG RRRGLSINSL SETQQSAMNS SLDHLQNDLN RINLQWNRIL SDNTNPLELA  60
   61 LAFLDDTSVG LGHRYEEFNQ LKSQIGSHLQ DVVNEHSQVF NTNVASYGKA VSSIMQAQEQ 120
  121 TLNLKNCLKE ANEKITTDKG SLQELNDNNL KYTKMIDVLV NIEELLQIPE KIEENIRKEN 180
  181 FHQVQILLER GFILMNNKSL KTVEILKPIN QQLELQEHLL FNNLIEEIHD IMYSKSNKTN 240
  241 FTRVTNNDIF KIISISHNGF TSLENYLYNI VNIDIMEHSK TINKNLEQFI HDQSLNKGNI 300
  301 MLQENAATQA PLAPSRNQEN EGFNRIGFLL KTINNINKLP VAFNIITERA KEEIHNIIVK 360
  361 STESIRSKHP SLLKMATSLK NDNHFGLPVQ DILSIILREC FWEIFLKLLY AIQCHRAIFE 420
  421 MSNILQPTSS AKPAFKFNKI WGKLLDEIEL LLVRYINDPE LISSNNGSIK PINGATNNAP 480
  481 TLPKRKNPKI FSLEYNIEDN SSVKDQAFEL KALLKDIFPG FSVSSNMDLD SIYVKDESFE 540
  541 QDEPLVPPSV FNMKVILDPF LLFTQSTSTI VPSVLTQNTI SSLTFFDDYM NKSFLPKIQM 600
  601 TMDYLFTVEV ESNNPYALEL SDENHNIFKT ALDFQRLFYN LLNVFNTANT FREKISYCIL 660
  661 DLLNHFYNYY LGLFNSLIGT SDRHLTRKII TAWLQNGILM DQEQKILNGD ETLFHEESIE 720
  721 LFKEIPHFYQ AGKGLSKSDL FNNLTLDTIL QFSASVLWIL NWLPGLKKAI NIDEVSQEPM 780
  781 LDADRLRSSW TFSESMDLNY SNPSSSPNSL GNLKILLDDK ASKKFDETID GFKTLKFKLI 840
  841 TILRFNIRAL CIYDIGSFFQ NTKIWNMDVG SIELDQNIAS LISELRRTES KLKQQLPEKE 900
  901 KNSIFIGLDI VNNYALIKGA KSIKVLNHNG IKKMLRNVNV LQHAYRNLSS EPSKINMNVT 960
  961 MNFYSLCGSS EAELFEYIKD NELPHCSVED LKTILRLQFS EEMHRQLKRQ STSSTKGSIK1020
 1021 PSNKRYTEAL EKLSNLEKEQ SKEGARTKIG KLKSKLNAVH TANEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
    View Details (MIPS) Mewes HW, et al. (2004) EXO70 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8
    View Details Gavin AC, et al. (2006) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
    View Details Gavin AC, et al. (2002) EXO84 SEC10 SEC3 SEC5 SEC6 SEC8 VPS9
    View Details Qiu et al. (2008) EXO70 EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 12.69897 Heavy meromyosin subfragment
    2 View Details [321..547] MSA 2.317989 View MSA. No confident structure predictions are available.
    3 View Details [548..677] MSA 1.015981 View MSA. Confident ab initio structure predictions are available.
    4 View Details [678..744] deduced N/A No confident structure predictions are available.
    5 View Details [745..1013] MSA 1.013948 View MSA. No confident structure predictions are available.
    6 View Details [1014..1065] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle