Protein Overview: FRE5

General Information:
Name(s) found:	FRE5 / YOR384W [SGD]
Description(s) found: Found 27 descriptions. SHOW ALL	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
Organism:	Saccharomyces cerevisiae
Length:	694 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ]
Biological Process:	biological_process [ND]
Molecular Function:	ferric-chelate reductase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFARLVLLL VYLAPGSLAK PASTKKRTQW DQIAIDACAK ELESHKFDTD VKGRHATLCT  60
   61 YEPALGSWLH CAKDVLDSRK KSKKIFEKTF SKINQYCHDY HKDEVVSNEE YYRIFANASL 120
  121 FIRPLDEVKE NIRYPVTPNK ASLDRWVWAY FGPLDNIDKG NVYGVTICLY WIGVLFIAAV 180
  181 YHFLNFSRLK QTVFKNKVSA FLRGHYVLPA LVHNHAMSVG RWFFIGLVPT RLETLVLFGY 240
  241 VLLHGFLLSS YNFDHNELLS DRRSQVLIFL SDRAGILAFA HFPLIVLFGG KNSTMTWLTG 300
  301 IRYTAFITYH KWLGRFMLVD CTIHAIGYTY HAYIENYWKY VKYSDLWTSG RHAMIIVGIL 360
  361 VFFSFFFFRR HYYELFVITH IILAIGFFHA CWKHCYKLGW GEWIMACALF WIADRILRLI 420
  421 KIAIFGMPWA KLKLCGESMI EVRISKSSKW WKAEPGQYIY LYFLRPKIFW QSHPFTVMDS 480
  481 LVEDGELVVV ITVKNGLTKK LQEYLLESEG YTEMRVLAEG PYGQSTRTHL FESLLFIAGG 540
  541 AGVPGPLSMA IKAGRQVKSN DSHQMIKFVW SVRNLDLLEV YRKEIMVLKE LNIDTKIYFT 600
  601 GERKDESNTE EGAIANMSTE GRLLTTSKSA EMITDFGRPN IDEIIEEAVS GAKSLLVTCC 660
  661 GSEGFVDKTR ELTAKRVLEH GDKWIEYVEE FQNW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GTS1	FRE5	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..185]	PSI-BLAST	5.045757	Troponin C
2	View Details	[186..345]	MSA	3.127989	View MSA. No confident structure predictions are available.
3	View Details	[346..524]	PSI-BLAST	42.045757	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
4	View Details	[525..694]	PSI-BLAST	42.045757	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
cation binding	2.62077305565026	bayes_pls_golite062009
metal ion binding	2.62077305565026	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.61874575467092	bayes_pls_golite062009
ion binding	2.61312132078717	bayes_pls_golite062009
ion transmembrane transporter activity	2.57032504567157	bayes_pls_golite062009
cation transmembrane transporter activity	2.55650624542181	bayes_pls_golite062009
binding	2.54774920478325	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37465721152046	bayes_pls_golite062009
cation channel activity	1.49312394054212	bayes_pls_golite062009
calcium ion binding	1.40919295397643	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
protein binding	1.06263369232144	bayes_pls_golite062009
channel activity	1.05847414989139	bayes_pls_golite062009
passive transmembrane transporter activity	1.05847414989139	bayes_pls_golite062009
ion channel activity	1.0369591011376	bayes_pls_golite062009
substrate-specific channel activity	1.03529144716694	bayes_pls_golite062009
voltage-gated cation channel activity	0.986621437232479	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
voltage-gated ion channel activity	0.910148857310729	bayes_pls_golite062009
potassium channel activity	0.906643355854798	bayes_pls_golite062009
voltage-gated channel activity	0.896351900356978	bayes_pls_golite062009
gated channel activity	0.855502499003241	bayes_pls_golite062009
voltage-gated potassium channel activity	0.810245330492755	bayes_pls_golite062009
substrate-specific transporter activity	0.693724160233023	bayes_pls_golite062009
transcription regulator activity	0.529057692398468	bayes_pls_golite062009
molecular transducer activity	0.503769734882556	bayes_pls_golite062009
signal transducer activity	0.503769734882556	bayes_pls_golite062009
hydrolase activity	0.378268353045111	bayes_pls_golite062009
nucleic acid binding	0.345084390599452	bayes_pls_golite062009
	0.34446792626966	bayes_pls_golite062009
channel regulator activity	0.32809521759917	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
DNA binding	0.14285249145193	bayes_pls_golite062009
cytoskeletal protein binding	0.0776924650284998	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
catalytic activity	1.45374095556065	bayes_pls_golite062009
transferase activity	1.15480450573972	bayes_pls_golite062009
binding	1.13408475648113	bayes_pls_golite062009
oxidoreductase activity	0.27336340260908	bayes_pls_golite062009
protein binding	0.144900113694048	bayes_pls_golite062009
cofactor binding	0.0731141170494622	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2