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Protein Overview: VHS3

General Information:
Name(s) found: VHS3 / YOR054C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 674 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    coenzyme A biosynthetic process [ISSLink to PubMed article]
    cellular monovalent inorganic cation homeostasis [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: phosphopantothenoylcysteine decarboxylase activity [ISSLink to PubMed article]
    phosphoprotein phosphatase inhibitor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNKSSLKNN RKGVASNTLS GAEQANIGSS AMPDTNSTGP FSSVSSLDTP VVRKSTSPTG  60
   61 SQTKSIMNAS GTSGAVVSNT PEPGLKRIPT VTFSDPKLGS LRSDVEQTPP NQVARQSSEK 120
  121 KATSVHIAAE GANQGRNLKD INTKVPKDGE ASASSFSTPT SILSNADMGN NISSLLAKKL 180
  181 SFTGGTDSIL NSDNSSDSPR KEHPHFYVED PLHTPSVRSR SNSTSPRPSV VVNTFNPINI 240
  241 EREGSISKTG EPTLLESVLE EAMSPNAVSN PLKRENIMTN MDPRLPQDDG KLHVLFGATG 300
  301 SLSVFKLKHM IRKLEEIYGR DKICIQVILT NSATKFFAMK YMRKNKKQHN SIDTSFNSTN 360
  361 SNAGNITGNK KKVASLEKFS IQKTSSNSAA SQTNNKQEEE KQMASTTGFP STLGGSRTYS 420
  421 NSSNVVSQHP QIELPAHIQF WTDQDEWDVW RQRTDPVLHI ELRRWADILV VAPLTANTLA 480
  481 KIALGLCDNL LTSVIRAWNP TFPIFLAPSM GSGTFNSIMT KKHFRIIQEE MPWVTVFKPS 540
  541 EKVMGINGDI GLSGMMDANE IVGKIVVKLG GYPDVSAGKE EEEDEDNDEE DDNKKNDTGG 600
  601 KDEDNDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD EDDEDEDEDD 660
  661 EGKKKEDKGG LQRS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAB3 SIS2 VHS3
    View Details Hazbun TR, et al. (2003) CAB3 SIS2 VHS3
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W
    View Details Ho Y, et al. (2002) GLC8 PPZ2 SDS22 VHS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..281] deduced N/A No confident structure predictions are available.
    2 View Details [282..375] Pcons 1.88 4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
    3 View Details [376..592] PSI-BLAST 371.9897 4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
    4 View Details [593..674] deduced N/A No confident structure predictions are available.
    5 View Details [574..674] PSI-BLAST 4.69897 Strucuture of the C-terminal domain of human thrombospondin-2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • phosphopantothenoylcysteine decarboxylase activity
    		•  3.86093811191169 bayes_pls_golite062009
  • phosphopantothenate--cysteine ligase activity
    		•  2.64345867885176 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.79168084682693 bayes_pls_golite062009
  • catalytic activity
    		•  1.51672397362026 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  1.03827559540394 bayes_pls_golite062009
  • binding
    		•  0.69350040563585 bayes_pls_golite062009
  • protein binding
    		•  0.003958060867923 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle