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Protein Overview: Mmp2-PB

General Information:
Name(s) found: Mmp2-PB / FBpp0087585 [FlyBase]
Description(s) found:
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  • gi|45552531|ref|NP_995788.1| matrix metalloproteinase 2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45445620|gb|AAS64885.1| matrix metalloproteinase 2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|21665775|emb|CAC81969.1| matrix metalloproteinase 2-MMP [Drosophila melanogaster] [NCBI NR]
  • Matrix metalloproteinase-2 OS=Drosophila melanogaster GN=Mmp2 PE=2 SV=1 [Swiss-Prot]
  • The gene Matrix metalloproteinase 2 is referred to in FlyBase by the symbol Dmel\Mmp2 (CG1794, FBgn0033438). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5498644..5571356. It has the cytological map location 45F6-46A1. There is experimental evidence that it has the molecular function</span>: metalloendopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: basement membrane disassembly; imaginal disc fusion, thorax closure; imaginal disc eversion; oogenesis. 113 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; adult thorax; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • (AAS64885) CG1794-PB [DrosMelano7227.FASTAC.txt]
  • CG1794-PB, isoform B [Drosophila melanogaster]gi|45552531|ref|NP_995788.1| CG1794-PB [Drosophila melanogaster]gi|21665775|emb|CAC81969.1| matrix metalloproteinase 2-MMP [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(5499597..5500123,5500193..5500334,5500399..5501264,5502332..5502477,5502868..5503008,5554870..5555072,5555178..5555279,5570288..5570437); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087 [fly-100309-contam.fasta]
  • Matrix metalloproteinase 2 CG1794-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1794-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • matrix metalloproteinase 2-MMP [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(5499597..5500123,5500193..5500334,5500399..5501264,5502332..5502477,5502868..5503008,5554870..5555072,5555178..5555279,5570288..5570437); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(5499597..5500123,5500193..5500334,5500399..5501264,5502332..5502477,5502868..5503008,5554870..5555072,5555178..5555279,5570288..5570437); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Matrix metalloproteinase 2 OS=Drosophila melanogaster GN=Mmp2 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(5499597..5500123,5500193..5500334,5500399..5501264,5502332..5502477,5502868..5503008,5554870..5555072,5555178..5555279,5570288..5570437); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885,FlyMine:FBpp0087585,modMine:FBpp0087585; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(9682783..9682932,9667673..9667774,9667365..9667567,9615363..9615503,9614827..9614972,9612894..9613759,9612688..9612829,9612092..9612618)); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885,FlyMine:FBpp0087585,modMine:FBpp0087585; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(9682783..9682932,9667673..9667774,9667365..9667567,9615363..9615503,9614827..9614972,9612894..9613759,9612688..9612829,9612092..9612618)); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885,FlyMine:FBpp0087585,modMine:FBpp0087585; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087585 type=protein; loc=2R:complement(join(9682783..9682932,9667673..9667774,9667365..9667567,9615363..9615503,9614827..9614972,9612894..9613759,9612688..9612829,9612092..9612618)); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885,FlyMine:FBpp0087585,modMine:FBpp0087585; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(9682783..9682932,9667673..9667774,9667365..9667567,9615363..9615503,9614827..9614972,9612894..9613759,9612688..9612829,9612092..9612618)); ID=FBpp0087585; name=Mmp2-PB; parent=FBgn0033438,FBtr0088501; dbxref=FlyBase:FBpp0087585,GB_protein:AAS64885.1,FlyBase_Annotation_IDs:CG1794-PB,REFSEQ:NP_995788,GB_protein:AAS64885,UniProt/Swiss-Prot:Q8MPP3,FlyMine:FBpp0087585,modMine:FBpp0087585; MD5=037c1d88832c493e193d8c97a10248a7; length=758; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: dendrite [IMP]
    extracellular matrix [IEA]
    plasma membrane [IDA]
    Biological Process: imaginal disc fusion, thorax closure [IMP]
    oogenesis [IMP]
    imaginal disc eversion [IMP]
    proteolysis [IEA]
    basement membrane disassembly [IMP]
    Molecular Function: zinc ion binding [IEA]
    metalloendopeptidase activity [IDA][ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSKYVLATL LALFAQSMCI QELSLPPEGS HSTAATRSKK AKTAISEDIM YNYLMQFDYL  60
   61 PKSDLETGAL RTEDQLKEAI RSLQSFGNIT VTGEIDSATA RLIQKPRCGV GDRRSADSFS 120
  121 PDNLYHEIGS NVRVRRFALQ GPKWSRTDLT WSMVNRSMPD ASKVERMVQT ALDVWANHSK 180
  181 LTFREVYSDQ ADIQILFARR AHGDGYKFDG PGQVLAHAFY PGEGRGGDAH FDADETWNFD 240
  241 GESDDSHGTN FLNVALHELG HSLGLAHSAI PDAVMFPWYQ NNEVAGNLPD DDRYGIQQLY 300
  301 GTKEKTWGPY KPQTTTTTTT TTTMRAMIYR ADKPAYWPWN NPSNNPNNDR NRARERQEEE 360
  361 RRRQEKERRR QEEERRHQEE ERRRQVEERQ RQEEERWRQE QERQEEENRR RKIEHKSQWE 420
  421 RNPSKERNRP RERQEMERRR QEQERQEQER QEQEDRRRER ERDRQLEWER RNRNGAREPV 480
  481 TPTANTTPRP TNKPYPTVHR QHHHHNKPRK PKPDSCMTYY DAISIIRGEL FIFRGPYLWR 540
  541 IGTSGLYNGY PTEIRRHWSA LPENLTKVDA VYENKQRQIV FFIGREYYVF NSVMLAPGFP 600
  601 KPLASLGLPP TLTHIDASFV WGHNNRTYMT SGTLYWRIDD YTGQVELDYP RDMSIWSGVG 660
  661 YNIDAAFQYL DGKTYFFKNL GYWEFNDDRM KVAHARAKLS ARRWMQCARS ANEVDDEQRW 720
  721 TASLVSEGEE TGRSGSRELR INHFILSILL LAIANWRS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..558] PSI-BLAST 83.0 X-ray structure of human proMMP-1: New insights into collagenase action
    2 View Details [559..758] PSI-BLAST 55.39794 C-TERMINAL DOMAIN OF GELATINASE A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.33358263548929 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.99457783001146 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.16532996235931 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.94798058866011 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.43236442601127 bayes_pls_golite062009
  • hydrolase activity
    		•  2.63109625301237 bayes_pls_golite062009
  • receptor binding
    		•  2.39767049122449 bayes_pls_golite062009
  • exopeptidase activity
    		•  2.07461908743946 bayes_pls_golite062009
  • fibronectin binding
    		•  1.96176072874085 bayes_pls_golite062009
  • binding
    		•  1.08558665967526 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • growth factor activity
    		•  0.720944017870466 bayes_pls_golite062009
  • integrin binding
    		•  0.57684135424992 bayes_pls_golite062009
  • zinc ion binding
    		•  0.49304764842799 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.489265029264191 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.393080846858665 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.374597710524442 bayes_pls_golite062009
  • protein binding
    		•  0.2751534129453 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  0.27229268642689 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.252655558968584 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.0255053415182105 bayes_pls_golite062009
  • ion binding
    		•  0.0127744064783182 bayes_pls_golite062009
    2
    Term Confidence Notes
  • peptidase activity
    		•  4.77605895108929 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.18827723759395 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.11406001246159 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.51480370240256 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.43398140790377 bayes_pls_golite062009
  • hydrolase activity
    		•  2.23273410408749 bayes_pls_golite062009
  • fibronectin binding
    		•  1.96176072874085 bayes_pls_golite062009
  • binding
    		•  1.84362171046259 bayes_pls_golite062009
  • receptor binding
    		•  1.44902010383702 bayes_pls_golite062009
  • catalytic activity
    		•  0.955691339512306 bayes_pls_golite062009
  • zinc ion binding
    		•  0.63810111577935 bayes_pls_golite062009
  • protein binding
    		•  0.555986151503952 bayes_pls_golite062009
  • ion binding
    		•  0.546436712108448 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.382258173896381 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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