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Protein Overview: srp-PA

General Information:
Name(s) found: srp-PA / FBpp0082669 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene serpent is referred to in FlyBase by the symbol Dmel\srp (CG3992, FBgn0003507). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11811923..11829807. It has the cytological map location 89A11-89A12. There is experimental evidence that it has the molecular function</span>: protein binding; sequence-specific DNA binding; transcription activator activity; DNA binding. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; embryonic development via the syncytial blastoderm; hemopoietic or lymphoid organ development; embryonic development ending in birth or egg hatching; transport; hemopoiesis; positive regulation of cellular biosynthetic process; gland morphogenesis; reproductive process in a multicellular organism; tissue homeostasis; cellular process. 75 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: organ system; primordium; embryonic/larval hemocoel; anatomical structure; cephalopharyngeal skeleton; late extended germ band embryo; embryonic nervous system; hemocyte; extended germ band embryo; cuticle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1264 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: dorsal closure [TAS]
    larval lymph gland hemopoiesis [TAS]
    germ-band shortening [IMP][TAS]
    midgut development [TAS]
    embryonic hemopoiesis [IMP][TAS]
    hemopoiesis [IEP][IMP][TAS]
    endoderm development [TAS]
    regulation of transcription [NAS]
    salivary gland morphogenesis [IMP]
    phagocytosis, engulfment [IMP]
    embryonic development via the syncytial blastoderm [NAS]
    positive regulation of transcription, DNA-dependent [IDA]
    lymph gland development [IMP]
    endoderm formation [TAS]
    cell fate determination [TAS]
    head involution [NAS]
    regulation of transcription, DNA-dependent [IEA][ISS]
    amnioserosa maintenance [IMP][TAS]
    germ cell migration [IMP][TAS]
    embryonic heart tube development [IMP]
    defense response [NAS]
    fat body development [IEP][TAS]
    crystal cell differentiation [TAS]
    cellular process [IMP]
    hemocyte development [IMP][NAS][TAS]
    mesodermal cell fate commitment [IMP]
    negative regulation of crystal cell differentiation [TAS]
    cell fate commitment [TAS]
    Molecular Function: DNA binding [IDA][TAS]
    zinc ion binding [IEA]
    transcription factor activity [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [ISS]
    general RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKTTKPKEK AAAGGAVIGS GSGLGSVTKA GGGSLLSNAA DSKIRTAKSN NNKRQAGRAA  60
   61 TALAATTTAS ALAATTTAGA TGSNAAANET EIAIETENGE AATPTAAATA AAANLSSLES 120
  121 ARSQALTSVV SETARQAVTT ANASATSTST VTAATEIATA TASDTAATSE AAIDDDPSAI 180
  181 NTNNNNNNSK AQNDASESVK TKVISYHQSE DQQQQQQQQA QIYEQQQQFL SQQLISHHQQ 240
  241 EQHQQAQQQQ HQQVVQEQHQ ASWLAYDLTS GSAAAAAAAA AAASHPHLFG QFSYPPSHHT 300
  301 PTQLYEHYPS TDPIMRNNFA FYSVYTGGGG GVGVGMTSHE HLAAAAAAAA AVAQGTTPNI 360
  361 DEVIQDTLKD ECFEDGHSTD YHVLTSVSDM HTLKDSSPYA LTHEQLHQQQ HHHQQQLHHH 420
  421 QQQQQQLYHQ QQQQQQQQQH HHHHNNSTSS AGGDSPSSSH ALSTLQSFTQ LTSATQRDSL 480
  481 SPENDAYFAA AQLGSSLQNS SVYAGSLLTQ TANGIQYGMQ SPNQTQAHLQ QQHHQQQQQQ 540
  541 HQQHQQQQLQ QQQQQHHHNQ HQHHNSSSSS PGPAGLHHSS SSAATAAAVA AATAAVNGHN 600
  601 SSLEDGYGSP RSSHSGGGGG GTLPAFQRIA YPNSGSVERY APITNYRGQN DTWFDPLSYA 660
  661 TSSSGQAQLG VGVGAGVVSN VIRNGRAISA ANAAAAAAAD GTTGRVDPGT FLSASASLSA 720
  721 MAAESGGDFY KPNSFNVGGG GRSKANTSGA ASSYSCPGSN ATSAATSAVA SGTAATAATT 780
  781 LDEHVSRANS RRLSASKRAG LSCSNCHTTH TSLWRRNPAG EPVCNACGLY YKLHSVPRPL 840
  841 TMKKDTIQKR KRKPKGTKSE KSKSKSKNAL NAIMESGSLV TNCHNVGVVL DSSQMDVNDD 900
  901 MKPQLDLKPY NSYSSQPQQQ LPQYQQQQQL LMADQHSSAA SSPHSMGSTS LSPSAMSHQH 960
  961 QTHPHQQQQQ QLCSGLDMSP NSNYQMSPLN MQQHQQQQSC SMQHSPSTPT SIFNTPSPTH1020
 1021 QLHNNNNNNN NSSIFNNNNN NNSSSNENNN KLIQKYLQAQ QLSSSSNSGS TSDHQLLAQL1080
 1081 LPNSITAAAA AAAAAAAAAI KTEALSLTSQ ANCSTASAGL MVTSTPTTAS STLSSLSHSN1140
 1141 IISLQNPYHQ AGMTLCKPTR PSPPYYLTPE EDEQPALIKM EEMDQSQQQQ QQQQHQQQQH1200
 1201 GEIMLSRSAS LDEHYELAAF QRHQQQQQQL QQQTAALLGQ HEQHVTNYAM HKFGVDRETV1260
 1261 VKME

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] deduced N/A No confident structure predictions are available.
    2 View Details [185..358] MSA 1.115987 View MSA. No confident structure predictions are available.
    3 View Details [359..477] deduced N/A No confident structure predictions are available.
    4 View Details [478..592] MSA 1.150984 View MSA. No confident structure predictions are available.
    5 View Details [593..770] deduced N/A No confident structure predictions are available.
    6 View Details [771..880] PSI-BLAST 5.69897 Erythroid transcription factor GATA-1
    7 View Details [881..957] deduced N/A No confident structure predictions are available.
    8 View Details [958..1126] MSA 1.14198 View MSA. No confident structure predictions are available.
    9 View Details [1127..1264] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  0.270879137859077 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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