Protein Overview: sl-PA

General Information:
Name(s) found:	sl-PA / FBpp0074009 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|77403871\|gb\|ABA81814.1\| RE62235p [Drosophila melanogaster] [NCBI NR] gi\|45549030\|ref\|NP_476726.2\| small wing [Drosophila melanogaster] [NCBI NR] gi\|45447021\|gb\|AAF48595.3\| small wing [Drosophila melanogaster] [NCBI NR] The gene small wing is referred to in FlyBase by the symbol Dmel\sl (CG4200, FBgn0003416). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16244342..16250520. It has the cytological map location 14B15-14B17. It is reported to have molecular function</span>: phosphoinositide phospholipase C activity. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration. 19 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; interommatidial bristle; primary pigment cell; primary segmental branch; cone cell; eye photoreceptor cell; wing; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase] (AAF48595) CG4200-PA [DrosMelano7227.FASTAC.txt] (AE003502) sl gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG4200-PA [Drosophila melanogaster]gi\|45549030\|ref\|NP_476726.2\| CG4200-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=X:join(16244619..16245923,16246282..16246762,16246828..16247681,16247749..16248819); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_ID [fly-100309-contam.fasta] CG4200-PA [Drosophila melanogaster] [nr-271106-contam.fasta] small wing CG4200-PA [Drosophila melanogaster] [nr-271106-contam.fasta] RE62235p [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:join(16244619..16245923,16246282..16246762,16246828..16247681,16247749..16248819); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:join(16244619..16245923,16246282..16246762,16246828..16247681,16247749..16248819); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] RE62235p OS=Drosophila melanogaster GN=sl PE=1 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=X:join(16244619..16245923,16246282..16246762,16246828..16247681,16247749..16248819); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595,FlyMine:FBpp0074009,modMine:FBpp0074009; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] RE62235p OS=Drosophila melanogaster GN=sl PE=2 SV=3 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=X:join(16350586..16351890,16352249..16352729,16352795..16353648,16353716..16354786); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595,FlyMine:FBpp0074009,modMine:FBpp0074009; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:join(16350586..16351890,16352249..16352729,16352795..16353648,16353716..16354786); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595,FlyMine:FBpp0074009,modMine:FBpp0074009; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Phosphoinositide phospholipase C OS=Drosophila melanogaster GN=sl PE=1 SV=3 [DROME.fasta.20160308] FBpp0074009 type=protein; loc=X:join(16350586..16351890,16352249..16352729,16352795..16353648,16353716..16354786); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595,FlyMine:FBpp0074009,modMine:FBpp0074009; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:join(16350586..16351890,16352249..16352729,16352795..16353648,16353716..16354786); ID=FBpp0074009; name=sl-PA; parent=FBgn0003416,FBtr0074230; dbxref=GB_protein:AAF48595.2,GB_protein:AAF48595.3,FlyBase:FBpp0074009,FlyBase_Annotation_IDs:CG4200-PA,REFSEQ:NP_476726,GB_protein:AAF48595,UniProt/TrEMBL:Q9VXH3,FlyMine:FBpp0074009,modMine:FBpp0074009; MD5=575b894eba6e6b37e145718bf80e31bb; length=1236; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1236 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	intracellular signaling pathway [IEA] phospholipid catabolic process [IEA] border follicle cell migration [IGI]
Molecular Function:	phosphoinositide phospholipase C activity [IEA][NAS] protein binding [IEA] signal transducer activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCFSAMSAP LLGEMEQTIG MLERGTIVTK LYGKQRRPDR RHLMLIRETR QLLWATVATQ  60
   61 TPRTDYEGAI QLREIREIRV GKHSKEFRLF ADDCQRFESS KCFVILHGNH FKLKSFSVVA 120
  121 LSEIEADNWV RGLRYMVKDT LGAPYPLQID RWLRREYYQI ENVNTHSAKA TEQSPAQVTI 180
  181 KDFKLFLAGV SCKMTTGKFM EHFTEDVRRK HDLKFDDFSR LYQKLLLPNG FASVLSGSGV 240
  241 ANFPYSEDQQ VVRPAELKQF LETEQRDVSA SEISSAAIAS FIRDFVQDVE RDVQEPYLTF 300
  301 PEFVDFLFSK QNDLWNSKYD QVFMDMNLPL SSYWIASSHN TYLTGDQFSS ESSCEAYARA 360
  361 LRMGCRCIEL DCWNGPDNLP YIFHGHTITS KIKFMDVIKT IKDHAFTSSE YPVILSIEQN 420
  421 CSLEQQRNMA QALIEVFGDM LLTQPCDRNE QHLPSPYQLR RKIILKHKKL PQFDDIANGI 480
  481 SSTGSLGHRS SLGGAGGGAH GENDGENVRK VFKEGLLYFK DPVDKSWNLY QFVLTHQELI 540
  541 YSSEINESRN GNSEDDDFGL SSSCSLNSNM QQKQKDTSAN DELHFGENWF HGKLEGGRKE 600
  601 ADDLLKKYKH FGDGTFLVRE SATFVGDYSL SFWRRNRPNH CRIKLKHENG SIKYYLVENF 660
  661 VFDSLYSLIV YYRKNMLRSS EFSIILKEPV PQPKKHEDQE WFHPNTTKEQ AEQGLYRLEI 720
  721 GSFLVRPSVQ SINAFVISFT INRKIKHCRI MQEGRLYGID TMNFESLVSL INYYTRNPLY 780
  781 RNVKLSHPVS QELLRQALAE AAQGDHSGGH DDNGASNYMG SNLEENVTCK ALYSYKANKP 840
  841 DELSFPKHAI ITNVQRDNSM WWIGDYGGMI KKHLPANYVK VIDSTTEDYN SLNEEGTDGR 900
  901 TDSIEIFGAV ASLFESNDPG IIFKLQIQTP TMQNPFVIGF DNQETAYEWI KAIQEAALIA 960
  961 SQLASERRKK ERTARVAKEM SDLIIYFRSV PFREHSWIFQ EMSSFPETKA EKQFFQQNTQ1020
 1021 LFLSYHRNQI SRVYPKGQRL DSSNFNPMPF WNVGSQMIAL NYQTGDKAMQ LNQAKFRNNG1080
 1081 QCGYILKPSF MKSDSFNPNN PLCDGLSEVK VSIRLIAARH LFRGGKSNNP QIVVELIGAS1140
 1141 FDTGVKYRTK VNENGFNPVW NESCEFNVRN PQFAILRFEV QDEDMFAETH FIAQACYPLT1200
 1201 CIRQGYRSVI LRNKFSEELE LSSLLINIKI ANVTAP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..501]	PSI-BLAST	113.0	No description for 2fjuB was found.
2	View Details	[502..563]	PSI-BLAST	93.69897	Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
3	View Details	[564..691]	PSI-BLAST	14.0	No description for 2dx0A was found.
4	View Details	[692..801]	PSI-BLAST	8.154902	Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
5	View Details	[802..892]	PSI-BLAST	6.30103	SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
6	View Details	[893..1103]	FFAS03	4.69	No description for 2fjuB was found.
7	View Details	[1104..1236]	PSI-BLAST	22.221849	Synaptogamin I

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
inositol or phosphatidylinositol phosphodiesterase activity	6.15718686264587	bayes_pls_golite062009
phosphoinositide phospholipase C activity	6.15718686264587	bayes_pls_golite062009
phosphoric diester hydrolase activity	2.72669081328574	bayes_pls_golite062009
ion transmembrane transporter activity	2.29802198409541	bayes_pls_golite062009
cation transmembrane transporter activity	2.28098452079347	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.12961051741613	bayes_pls_golite062009
type 5 metabotropic glutamate receptor binding	1.93759929338478	bayes_pls_golite062009
insulin receptor binding	1.93662993549038	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.74951443813569	bayes_pls_golite062009
phospholipase C activity	1.69567069819233	bayes_pls_golite062009
hydrolase activity	1.46651177055731	bayes_pls_golite062009
protein binding	1.44033231686342	bayes_pls_golite062009
cytoskeletal protein binding	1.39151230336065	bayes_pls_golite062009
actin binding	1.31073403549236	bayes_pls_golite062009
transporter activity	1.28986800087234	bayes_pls_golite062009
catalytic activity	1.22328099675039	bayes_pls_golite062009
receptor activity	1.1755016270537	bayes_pls_golite062009
enzyme binding	1.17212675145623	bayes_pls_golite062009
molecular transducer activity	1.16145643812759	bayes_pls_golite062009
signal transducer activity	1.16145643812759	bayes_pls_golite062009
transmembrane receptor activity	1.1152029796159	bayes_pls_golite062009
phosphoric ester hydrolase activity	1.11279017101076	bayes_pls_golite062009
binding	1.04499989705786	bayes_pls_golite062009
receptor binding	1.00859318603128	bayes_pls_golite062009
phospholipase activity	0.964221011759725	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.936568622355831	bayes_pls_golite062009
protein domain specific binding	0.90578029954417	bayes_pls_golite062009
cation channel activity	0.856991182112951	bayes_pls_golite062009
calcium-dependent protein binding	0.618263020102914	bayes_pls_golite062009
transcription regulator activity	0.6040937268283	bayes_pls_golite062009
nucleic acid binding	0.582622360049197	bayes_pls_golite062009
protein complex binding	0.55916857709427	bayes_pls_golite062009
substrate-specific transporter activity	0.54401901869178	bayes_pls_golite062009
DNA binding	0.42187920415022	bayes_pls_golite062009
kinase binding	0.39940885913863	bayes_pls_golite062009
substrate-specific channel activity	0.366129174039334	bayes_pls_golite062009
voltage-gated cation channel activity	0.341357838238159	bayes_pls_golite062009
channel regulator activity	0.32809521759917	bayes_pls_golite062009
voltage-gated channel activity	0.308919475701377	bayes_pls_golite062009
actin filament binding	0.30490110583969	bayes_pls_golite062009
voltage-gated ion channel activity	0.304496519713588	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity	0.28468123649303	bayes_pls_golite062009
potassium channel activity	0.260530997378698	bayes_pls_golite062009
lipase activity	0.254072795277849	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.199129147821312	bayes_pls_golite062009
gated channel activity	0.175191914660841	bayes_pls_golite062009
voltage-gated potassium channel activity	0.157059988605635	bayes_pls_golite062009
receptor signaling protein activity	0.10105990547756	bayes_pls_golite062009
protein kinase binding	0.0918356351234999	bayes_pls_golite062009
channel activity	0.0711800677928949	bayes_pls_golite062009
passive transmembrane transporter activity	0.0711800677928949	bayes_pls_golite062009
ion channel activity	0.0166394982861724	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
inositol or phosphatidylinositol phosphodiesterase activity	3.28815391934124	bayes_pls_golite062009
phosphoinositide phospholipase C activity	3.28815391934124	bayes_pls_golite062009
protein binding	3.19631993182765	bayes_pls_golite062009
molecular transducer activity	3.13508395312263	bayes_pls_golite062009
signal transducer activity	3.13508395312263	bayes_pls_golite062009
insulin receptor binding	2.54715474632117	bayes_pls_golite062009
binding	2.48735671726158	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
receptor binding	1.52843393025918	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
transcription regulator activity	0.820346045867305	bayes_pls_golite062009
nucleic acid binding	0.816146040174831	bayes_pls_golite062009
protein complex binding	0.65988681496356	bayes_pls_golite062009
protein phosphorylated amino acid binding	0.649814096718101	bayes_pls_golite062009
DNA binding	0.56708736413279	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
phosphoprotein binding	0.16798254471727	bayes_pls_golite062009

Term	Confidence	Notes
protein binding	3.13677730481089	bayes_pls_golite062009
binding	2.42916850671495	bayes_pls_golite062009
ion transmembrane transporter activity	2.38220960676668	bayes_pls_golite062009
cytoskeletal protein binding	2.32129643848552	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.24634655033797	bayes_pls_golite062009
actin binding	1.49364020386646	bayes_pls_golite062009
signal transducer activity	1.34867629228264	bayes_pls_golite062009
molecular transducer activity	1.34867629228264	bayes_pls_golite062009
transporter activity	1.30447542854757	bayes_pls_golite062009
transmembrane transporter activity	1.08558010881058	bayes_pls_golite062009
actin filament binding	0.99953968189322	bayes_pls_golite062009
substrate-specific transporter activity	0.566172161499832	bayes_pls_golite062009
insulin receptor binding	0.0882113091771992	bayes_pls_golite062009
receptor binding	0.0742205785215131	bayes_pls_golite062009

Term	Confidence	Notes
inositol or phosphatidylinositol phosphodiesterase activity	5.57271064062643	bayes_pls_golite062009
phosphoinositide phospholipase C activity	5.57271064062643	bayes_pls_golite062009
phosphoric diester hydrolase activity	2.12880238332877	bayes_pls_golite062009
protein binding	1.44946093983848	bayes_pls_golite062009
hydrolase activity	1.28019231914023	bayes_pls_golite062009
signal transducer activity	1.16625570273126	bayes_pls_golite062009
molecular transducer activity	1.16625570273126	bayes_pls_golite062009
catalytic activity	1.14265621143219	bayes_pls_golite062009
phospholipase C activity	1.10192260662888	bayes_pls_golite062009
binding	1.07724211608484	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.703846812632842	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.602886884806896	bayes_pls_golite062009
phospholipase activity	0.474613920515911	bayes_pls_golite062009

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Protein Overview: sl-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: