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View Structure Prediction Details

Protein: sl-PA
Organism: Drosophila melanogaster
Length: 1236 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sl-PA.

Description E-value Query
Range		 Subject
Range
gi|1109616 - gi|1109616|dbj|BAA06189.1| PLC-gamma D [Drosophila melanogaster]
 877.0 [0..7] [1236..1]

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Predicted Domain #1
Region A:
Residues: [1-501] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCFSAMSAP LLGEMEQTIG MLERGTIVTK LYGKQRRPDR RHLMLIRETR QLLWATVATQ  60
   61 TPRTDYEGAI QLREIREIRV GKHSKEFRLF ADDCQRFESS KCFVILHGNH FKLKSFSVVA 120
  121 LSEIEADNWV RGLRYMVKDT LGAPYPLQID RWLRREYYQI ENVNTHSAKA TEQSPAQVTI 180
  181 KDFKLFLAGV SCKMTTGKFM EHFTEDVRRK HDLKFDDFSR LYQKLLLPNG FASVLSGSGV 240
  241 ANFPYSEDQQ VVRPAELKQF LETEQRDVSA SEISSAAIAS FIRDFVQDVE RDVQEPYLTF 300
  301 PEFVDFLFSK QNDLWNSKYD QVFMDMNLPL SSYWIASSHN TYLTGDQFSS ESSCEAYARA 360
  361 LRMGCRCIEL DCWNGPDNLP YIFHGHTITS KIKFMDVIKT IKDHAFTSSE YPVILSIEQN 420
  421 CSLEQQRNMA QALIEVFGDM LLTQPCDRNE QHLPSPYQLR RKIILKHKKL PQFDDIANGI 480
  481 SSTGSLGHRS SLGGAGGGAH G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 113.0
Match: 2fjuB
Description: No description for 2fjuB was found.

Predicted functions:

Term Confidence Notes
inositol or phosphatidylinositol phosphodiesterase activity 6.15718686264587 bayes_pls_golite062009
phosphoinositide phospholipase C activity 6.15718686264587 bayes_pls_golite062009
phosphoric diester hydrolase activity 2.72669081328574 bayes_pls_golite062009
ion transmembrane transporter activity 2.29802198409541 bayes_pls_golite062009
cation transmembrane transporter activity 2.28098452079347 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.12961051741613 bayes_pls_golite062009
type 5 metabotropic glutamate receptor binding 1.93759929338478 bayes_pls_golite062009
insulin receptor binding 1.93662993549038 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.74951443813569 bayes_pls_golite062009
phospholipase C activity 1.69567069819233 bayes_pls_golite062009
hydrolase activity 1.46651177055731 bayes_pls_golite062009
protein binding 1.44033231686342 bayes_pls_golite062009
cytoskeletal protein binding 1.39151230336065 bayes_pls_golite062009
actin binding 1.31073403549236 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
catalytic activity 1.22328099675039 bayes_pls_golite062009
receptor activity 1.1755016270537 bayes_pls_golite062009
enzyme binding 1.17212675145623 bayes_pls_golite062009
molecular transducer activity 1.16145643812759 bayes_pls_golite062009
signal transducer activity 1.16145643812759 bayes_pls_golite062009
transmembrane receptor activity 1.1152029796159 bayes_pls_golite062009
phosphoric ester hydrolase activity 1.11279017101076 bayes_pls_golite062009
binding 1.04499989705786 bayes_pls_golite062009
receptor binding 1.00859318603128 bayes_pls_golite062009
phospholipase activity 0.964221011759725 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.936568622355831 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
cation channel activity 0.856991182112951 bayes_pls_golite062009
calcium-dependent protein binding 0.618263020102914 bayes_pls_golite062009
transcription regulator activity 0.6040937268283 bayes_pls_golite062009
nucleic acid binding 0.582622360049197 bayes_pls_golite062009
protein complex binding 0.55916857709427 bayes_pls_golite062009
substrate-specific transporter activity 0.54401901869178 bayes_pls_golite062009
DNA binding 0.42187920415022 bayes_pls_golite062009
kinase binding 0.39940885913863 bayes_pls_golite062009
substrate-specific channel activity 0.366129174039334 bayes_pls_golite062009
voltage-gated cation channel activity 0.341357838238159 bayes_pls_golite062009
channel regulator activity 0.32809521759917 bayes_pls_golite062009
voltage-gated channel activity 0.308919475701377 bayes_pls_golite062009
actin filament binding 0.30490110583969 bayes_pls_golite062009
voltage-gated ion channel activity 0.304496519713588 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 0.28468123649303 bayes_pls_golite062009
potassium channel activity 0.260530997378698 bayes_pls_golite062009
lipase activity 0.254072795277849 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.199129147821312 bayes_pls_golite062009
gated channel activity 0.175191914660841 bayes_pls_golite062009
voltage-gated potassium channel activity 0.157059988605635 bayes_pls_golite062009
receptor signaling protein activity 0.10105990547756 bayes_pls_golite062009
protein kinase binding 0.0918356351234999 bayes_pls_golite062009
channel activity 0.0711800677928949 bayes_pls_golite062009
passive transmembrane transporter activity 0.0711800677928949 bayes_pls_golite062009
ion channel activity 0.0166394982861724 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [502-563] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENDGENVRKV FKEGLLYFKD PVDKSWNLYQ FVLTHQELIY SSEINESRNG NSEDDDFGLS  60
   61 SS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.69897
Match: 1djgA
Description: Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [564-691] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSLNSNMQQK QKDTSANDEL HFGENWFHGK LEGGRKEADD LLKKYKHFGD GTFLVRESAT  60
   61 FVGDYSLSFW RRNRPNHCRI KLKHENGSIK YYLVENFVFD SLYSLIVYYR KNMLRSSEFS 120
  121 IILKEPVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 2dx0A
Description: No description for 2dx0A was found.

Predicted Domain #4
Region A:
Residues: [692-801] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPKKHEDQEW FHPNTTKEQA EQGLYRLEIG SFLVRPSVQS INAFVISFTI NRKIKHCRIM  60
   61 QEGRLYGIDT MNFESLVSLI NYYTRNPLYR NVKLSHPVSQ ELLRQALAEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.154902
Match: 2fciA
Description: Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
inositol or phosphatidylinositol phosphodiesterase activity 3.28815391934124 bayes_pls_golite062009
phosphoinositide phospholipase C activity 3.28815391934124 bayes_pls_golite062009
protein binding 3.19631993182765 bayes_pls_golite062009
molecular transducer activity 3.13508395312263 bayes_pls_golite062009
signal transducer activity 3.13508395312263 bayes_pls_golite062009
insulin receptor binding 2.54715474632117 bayes_pls_golite062009
binding 2.48735671726158 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
receptor binding 1.52843393025918 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transcription regulator activity 0.820346045867305 bayes_pls_golite062009
nucleic acid binding 0.816146040174831 bayes_pls_golite062009
protein complex binding 0.65988681496356 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.649814096718101 bayes_pls_golite062009
DNA binding 0.56708736413279 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [802-892] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQGDHSGGHD DNGASNYMGS NLEENVTCKA LYSYKANKPD ELSFPKHAII TNVQRDNSMW  60
   61 WIGDYGGMIK KHLPANYVKV IDSTTEDYNS L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.30103
Match: 1hsqA
Description: SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.13677730481089 bayes_pls_golite062009
binding 2.42916850671495 bayes_pls_golite062009
ion transmembrane transporter activity 2.38220960676668 bayes_pls_golite062009
cytoskeletal protein binding 2.32129643848552 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.24634655033797 bayes_pls_golite062009
actin binding 1.49364020386646 bayes_pls_golite062009
signal transducer activity 1.34867629228264 bayes_pls_golite062009
molecular transducer activity 1.34867629228264 bayes_pls_golite062009
transporter activity 1.30447542854757 bayes_pls_golite062009
transmembrane transporter activity 1.08558010881058 bayes_pls_golite062009
actin filament binding 0.99953968189322 bayes_pls_golite062009
substrate-specific transporter activity 0.566172161499832 bayes_pls_golite062009
insulin receptor binding 0.0882113091771992 bayes_pls_golite062009
receptor binding 0.0742205785215131 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [893-1103] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEEGTDGRTD SIEIFGAVAS LFESNDPGII FKLQIQTPTM QNPFVIGFDN QETAYEWIKA  60
   61 IQEAALIASQ LASERRKKER TARVAKEMSD LIIYFRSVPF REHSWIFQEM SSFPETKAEK 120
  121 QFFQQNTQLF LSYHRNQISR VYPKGQRLDS SNFNPMPFWN VGSQMIALNY QTGDKAMQLN 180
  181 QAKFRNNGQC GYILKPSFMK SDSFNPNNPL C

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.69
Match: 2fjuB
Description: No description for 2fjuB was found.

Predicted functions:

Term Confidence Notes
inositol or phosphatidylinositol phosphodiesterase activity 5.57271064062643 bayes_pls_golite062009
phosphoinositide phospholipase C activity 5.57271064062643 bayes_pls_golite062009
phosphoric diester hydrolase activity 2.12880238332877 bayes_pls_golite062009
protein binding 1.44946093983848 bayes_pls_golite062009
hydrolase activity 1.28019231914023 bayes_pls_golite062009
signal transducer activity 1.16625570273126 bayes_pls_golite062009
molecular transducer activity 1.16625570273126 bayes_pls_golite062009
catalytic activity 1.14265621143219 bayes_pls_golite062009
phospholipase C activity 1.10192260662888 bayes_pls_golite062009
binding 1.07724211608484 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.703846812632842 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.602886884806896 bayes_pls_golite062009
phospholipase activity 0.474613920515911 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1104-1236] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGLSEVKVSI RLIAARHLFR GGKSNNPQIV VELIGASFDT GVKYRTKVNE NGFNPVWNES  60
   61 CEFNVRNPQF AILRFEVQDE DMFAETHFIA QACYPLTCIR QGYRSVILRN KFSEELELSS 120
  121 LLINIKIANV TAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 1dqvA
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle