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Protein Overview: sl-PA

General Information:
Name(s) found: sl-PA / FBpp0074009 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene small wing is referred to in FlyBase by the symbol Dmel\sl (CG4200, FBgn0003416). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16244342..16250520. It has the cytological map location 14B15-14B17. It is reported to have molecular function</span>: phosphoinositide phospholipase C activity. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration. 19 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; interommatidial bristle; primary pigment cell; primary segmental branch; cone cell; eye photoreceptor cell; wing; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1236 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: intracellular signaling pathway [IEA]
    phospholipid catabolic process [IEA]
    border follicle cell migration [IGI]
    Molecular Function: phosphoinositide phospholipase C activity [IEA][NAS]
    protein binding [IEA]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCFSAMSAP LLGEMEQTIG MLERGTIVTK LYGKQRRPDR RHLMLIRETR QLLWATVATQ  60
   61 TPRTDYEGAI QLREIREIRV GKHSKEFRLF ADDCQRFESS KCFVILHGNH FKLKSFSVVA 120
  121 LSEIEADNWV RGLRYMVKDT LGAPYPLQID RWLRREYYQI ENVNTHSAKA TEQSPAQVTI 180
  181 KDFKLFLAGV SCKMTTGKFM EHFTEDVRRK HDLKFDDFSR LYQKLLLPNG FASVLSGSGV 240
  241 ANFPYSEDQQ VVRPAELKQF LETEQRDVSA SEISSAAIAS FIRDFVQDVE RDVQEPYLTF 300
  301 PEFVDFLFSK QNDLWNSKYD QVFMDMNLPL SSYWIASSHN TYLTGDQFSS ESSCEAYARA 360
  361 LRMGCRCIEL DCWNGPDNLP YIFHGHTITS KIKFMDVIKT IKDHAFTSSE YPVILSIEQN 420
  421 CSLEQQRNMA QALIEVFGDM LLTQPCDRNE QHLPSPYQLR RKIILKHKKL PQFDDIANGI 480
  481 SSTGSLGHRS SLGGAGGGAH GENDGENVRK VFKEGLLYFK DPVDKSWNLY QFVLTHQELI 540
  541 YSSEINESRN GNSEDDDFGL SSSCSLNSNM QQKQKDTSAN DELHFGENWF HGKLEGGRKE 600
  601 ADDLLKKYKH FGDGTFLVRE SATFVGDYSL SFWRRNRPNH CRIKLKHENG SIKYYLVENF 660
  661 VFDSLYSLIV YYRKNMLRSS EFSIILKEPV PQPKKHEDQE WFHPNTTKEQ AEQGLYRLEI 720
  721 GSFLVRPSVQ SINAFVISFT INRKIKHCRI MQEGRLYGID TMNFESLVSL INYYTRNPLY 780
  781 RNVKLSHPVS QELLRQALAE AAQGDHSGGH DDNGASNYMG SNLEENVTCK ALYSYKANKP 840
  841 DELSFPKHAI ITNVQRDNSM WWIGDYGGMI KKHLPANYVK VIDSTTEDYN SLNEEGTDGR 900
  901 TDSIEIFGAV ASLFESNDPG IIFKLQIQTP TMQNPFVIGF DNQETAYEWI KAIQEAALIA 960
  961 SQLASERRKK ERTARVAKEM SDLIIYFRSV PFREHSWIFQ EMSSFPETKA EKQFFQQNTQ1020
 1021 LFLSYHRNQI SRVYPKGQRL DSSNFNPMPF WNVGSQMIAL NYQTGDKAMQ LNQAKFRNNG1080
 1081 QCGYILKPSF MKSDSFNPNN PLCDGLSEVK VSIRLIAARH LFRGGKSNNP QIVVELIGAS1140
 1141 FDTGVKYRTK VNENGFNPVW NESCEFNVRN PQFAILRFEV QDEDMFAETH FIAQACYPLT1200
 1201 CIRQGYRSVI LRNKFSEELE LSSLLINIKI ANVTAP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..501] PSI-BLAST 113.0 No description for 2fjuB was found.
    2 View Details [502..563] PSI-BLAST 93.69897 Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)
    3 View Details [564..691] PSI-BLAST 14.0 No description for 2dx0A was found.
    4 View Details [692..801] PSI-BLAST 8.154902 Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
    5 View Details [802..892] PSI-BLAST 6.30103 SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
    6 View Details [893..1103] FFAS03 4.69 No description for 2fjuB was found.
    7 View Details [1104..1236] PSI-BLAST 22.221849 Synaptogamin I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • inositol or phosphatidylinositol phosphodiesterase activity
    		•  6.15718686264587 bayes_pls_golite062009
  • phosphoinositide phospholipase C activity
    		•  6.15718686264587 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  2.72669081328574 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.29802198409541 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.28098452079347 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.12961051741613 bayes_pls_golite062009
  • type 5 metabotropic glutamate receptor binding
    		•  1.93759929338478 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.93662993549038 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.74951443813569 bayes_pls_golite062009
  • phospholipase C activity
    		•  1.69567069819233 bayes_pls_golite062009
  • hydrolase activity
    		•  1.46651177055731 bayes_pls_golite062009
  • protein binding
    		•  1.44033231686342 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.39151230336065 bayes_pls_golite062009
  • actin binding
    		•  1.31073403549236 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • catalytic activity
    		•  1.22328099675039 bayes_pls_golite062009
  • receptor activity
    		•  1.1755016270537 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.16145643812759 bayes_pls_golite062009
  • signal transducer activity
    		•  1.16145643812759 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.1152029796159 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.11279017101076 bayes_pls_golite062009
  • binding
    		•  1.04499989705786 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • phospholipase activity
    		•  0.964221011759725 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.936568622355831 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • cation channel activity
    		•  0.856991182112951 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  0.618263020102914 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.6040937268283 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.582622360049197 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.54401901869178 bayes_pls_golite062009
  • DNA binding
    		•  0.42187920415022 bayes_pls_golite062009
  • kinase binding
    		•  0.39940885913863 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.366129174039334 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.341357838238159 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.308919475701377 bayes_pls_golite062009
  • actin filament binding
    		•  0.30490110583969 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.304496519713588 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.28468123649303 bayes_pls_golite062009
  • potassium channel activity
    		•  0.260530997378698 bayes_pls_golite062009
  • lipase activity
    		•  0.254072795277849 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.199129147821312 bayes_pls_golite062009
  • gated channel activity
    		•  0.175191914660841 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.157059988605635 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.10105990547756 bayes_pls_golite062009
  • protein kinase binding
    		•  0.0918356351234999 bayes_pls_golite062009
  • channel activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0711800677928949 bayes_pls_golite062009
  • ion channel activity
    		•  0.0166394982861724 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • inositol or phosphatidylinositol phosphodiesterase activity
    		•  3.28815391934124 bayes_pls_golite062009
  • phosphoinositide phospholipase C activity
    		•  3.28815391934124 bayes_pls_golite062009
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.54715474632117 bayes_pls_golite062009
  • binding
    		•  2.48735671726158 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • receptor binding
    		•  1.52843393025918 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.820346045867305 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.816146040174831 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • DNA binding
    		•  0.56708736413279 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
    5
    Term Confidence Notes
  • protein binding
    		•  3.13677730481089 bayes_pls_golite062009
  • binding
    		•  2.42916850671495 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.38220960676668 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.32129643848552 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.24634655033797 bayes_pls_golite062009
  • actin binding
    		•  1.49364020386646 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34867629228264 bayes_pls_golite062009
  • transporter activity
    		•  1.30447542854757 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08558010881058 bayes_pls_golite062009
  • actin filament binding
    		•  0.99953968189322 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.566172161499832 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.0882113091771992 bayes_pls_golite062009
  • receptor binding
    		•  0.0742205785215131 bayes_pls_golite062009
    6
    Term Confidence Notes
  • inositol or phosphatidylinositol phosphodiesterase activity
    		•  5.57271064062643 bayes_pls_golite062009
  • phosphoinositide phospholipase C activity
    		•  5.57271064062643 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  2.12880238332877 bayes_pls_golite062009
  • protein binding
    		•  1.44946093983848 bayes_pls_golite062009
  • hydrolase activity
    		•  1.28019231914023 bayes_pls_golite062009
  • signal transducer activity
    		•  1.16625570273126 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.16625570273126 bayes_pls_golite062009
  • catalytic activity
    		•  1.14265621143219 bayes_pls_golite062009
  • phospholipase C activity
    		•  1.10192260662888 bayes_pls_golite062009
  • binding
    		•  1.07724211608484 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.703846812632842 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.602886884806896 bayes_pls_golite062009
  • phospholipase activity
    		•  0.474613920515911 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle