Protein Overview: CH60_RAT

General Information:
Name(s) found:	CH60_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|55778012\|gb\|AAH86507.1\| Heat shock protein 1 (chaperonin) [Rattus norvegicus] [NCBI NR] gi\|51702230\|sp\|P63039.1\|CH60_RAT RecName: Full=60 kDa heat shock protein, mitochondrial; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Mitochondrial [NCBI NR] gi\|206597443\|ref\|NP_071565.2\| heat shock protein 1 (chaperonin) [Rattus norvegicus] [NCBI NR] gi\|149046159\|gb\|EDL99052.1\| rCG22608, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149046158\|gb\|EDL99051.1\| rCG22608, isoform CRA_a [Rattus norvegicus] [NCBI NR] 60 kDa heat shock protein, mitochondrial OS=Rattus norvegicus GN=Hspd1 PE=1 SV=1 [Swiss-Prot] Heat shock protein 1 (chaperonin) [Mus musculus]gi\|51702252\|sp\|P63038\|CH60_MOUSE 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65)gi\|5170223 [nrdb_11152004_Chlamydomonas] Tax_Id=10116 60 kDa heat shock protein, mitochondrial precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] 60 kDa heat shock protein, mitochondrial precursor (Heat shock protein 60) (HSP-60) (Hsp60) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Mitochondrial matrix protein P1) (HSP-65) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] rCG22608, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Heat shock protein 1 (chaperonin) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] heat shock protein 1 (chaperonin) [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Hspd1 60 kDa heat shock protein, mitochondrial [rat-ipi-250309-contam.fasta] 60 kDa heat shock protein, mitochondrial OS=Rattus norvegicus GN=Hspd1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	573 amino acids
Gene Ontology:
Cellular Component:	mitochondrial crista [IDA] secretory granule [UNKNOWN][IDA] cyclin-dependent protein kinase activating kinase holoenzyme complex [UNKNOWN] rough endoplasmic reticulum [IDA] Golgi apparatus [IDA] zymogen granule [IDA] mitochondrial inner membrane [UNKNOWN] cell surface [UNKNOWN][IDA] plasma membrane part [UNKNOWN] extracellular space [UNKNOWN] early endosome [UNKNOWN] cytoplasm [IDA][IEA] mitochondrial matrix [IEA] lipopolysaccharide receptor complex [UNKNOWN] coated pit [UNKNOWN] intracellular membrane-bounded organelle [UNKNOWN] mitochondrion [UNKNOWN][IDA] membrane raft [IDA] cytosol [UNKNOWN][IDA] coated vesicle [UNKNOWN]
Biological Process:	response to estrogen stimulus [IEP] T cell activation [UNKNOWN] B cell activation [UNKNOWN] positive regulation of anti-apoptosis [IMP] response to unfolded protein [UNKNOWN] detection of misfolded protein [IDA] positive regulation of interferon-alpha production [UNKNOWN] response to heat [IEP] positive regulation of T cell activation [UNKNOWN] response to hypoxia [IEP] MyD88-dependent toll-like receptor signaling pathway [UNKNOWN] anti-apoptosis [IMP] positive regulation of interferon-gamma production [UNKNOWN] positive regulation of macrophage activation [UNKNOWN] activation of caspase activity [UNKNOWN] response to organic substance [IEP] response to ATP [IEP] positive regulation of inflammatory response [IDA] response to cocaine [IEP] B cell proliferation [UNKNOWN] chaperone mediated protein folding requiring cofactor [IDA] response to organic cyclic substance [IEP] response to hydrogen peroxide [IEP] protein folding [IEA] protein refolding [UNKNOWN] 'de novo' protein folding [IC] B cell cytokine production [UNKNOWN] positive regulation of T cell mediated immune response to tumor cell [UNKNOWN] positive regulation of interleukin-12 production [UNKNOWN] response to drug [IEP] negative regulation of apoptosis [UNKNOWN] positive regulation of apoptosis [UNKNOWN] response to lipopolysaccharide [IEP] positive regulation of interleukin-10 production [UNKNOWN] positive regulation of interleukin-6 production [UNKNOWN] protein stabilization [UNKNOWN] isotype switching to IgG isotypes [UNKNOWN]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] insulin binding [IPI] p53 binding [UNKNOWN] protein binding [UNKNOWN][IEA][IPI] protein heterodimerization activity [IPI] chaperone binding [UNKNOWN] protease binding [IPI] cell surface binding [UNKNOWN] protein complex binding [IPI] misfolded protein binding [IPI] lipopolysaccharide binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRLPTVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR  60
   61 TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA 120
  121 RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK 180
  181 DIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ 240
  241 DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV 300
  301 KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQAH DLGKVGEVIV TKDDAMLLKG 360
  361 KGDKAHIEKR IQEITEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR 420
  421 VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLKPANED QKIGIEIIKR ALKIPAMTIA 480
  481 KNAGVEGSLI VEKILQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT 540
  541 TAEAVVTEIP KEEKDPGMGA MGGMGGGMGG GMF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.63

Protein Overview: CH60_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: