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Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: MyD88-dependent toll-like receptor signaling pathway
Acc: GO:0002755
Aspect: Biological Process
Desc: Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
Synonyms:
  • MyD88-dependent TLR signaling pathway
  • MyD88-dependent toll-like receptor signalling pathway
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002755 - MyD88-dependent toll-like receptor signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle