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Protein Overview: CH60_RAT

General Information:
Name(s) found: CH60_RAT [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • 60 kDa heat shock protein, mitochondrial OS=Rattus norvegicus GN=Hspd1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 573 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial crista [IDA]
    secretory granule [UNKNOWN][IDA]
    cyclin-dependent protein kinase activating kinase holoenzyme complex [UNKNOWN]
    rough endoplasmic reticulum [IDA]
    Golgi apparatus [IDA]
    zymogen granule [IDA]
    mitochondrial inner membrane [UNKNOWN]
    cell surface [UNKNOWN][IDA]
    plasma membrane part [UNKNOWN]
    extracellular space [UNKNOWN]
    early endosome [UNKNOWN]
    cytoplasm [IDA][IEA]
    mitochondrial matrix [IEA]
    lipopolysaccharide receptor complex [UNKNOWN]
    coated pit [UNKNOWN]
    intracellular membrane-bounded organelle [UNKNOWN]
    mitochondrion [UNKNOWN][IDA]
    membrane raft [IDA]
    cytosol [UNKNOWN][IDA]
    coated vesicle [UNKNOWN]
    Biological Process: response to estrogen stimulus [IEP]
    T cell activation [UNKNOWN]
    B cell activation [UNKNOWN]
    positive regulation of anti-apoptosis [IMP]
    response to unfolded protein [UNKNOWN]
    detection of misfolded protein [IDA]
    positive regulation of interferon-alpha production [UNKNOWN]
    response to heat [IEP]
    positive regulation of T cell activation [UNKNOWN]
    response to hypoxia [IEP]
    MyD88-dependent toll-like receptor signaling pathway [UNKNOWN]
    anti-apoptosis [IMP]
    positive regulation of interferon-gamma production [UNKNOWN]
    positive regulation of macrophage activation [UNKNOWN]
    activation of caspase activity [UNKNOWN]
    response to organic substance [IEP]
    response to ATP [IEP]
    positive regulation of inflammatory response [IDA]
    response to cocaine [IEP]
    B cell proliferation [UNKNOWN]
    chaperone mediated protein folding requiring cofactor [IDA]
    response to organic cyclic substance [IEP]
    response to hydrogen peroxide [IEP]
    protein folding [IEA]
    protein refolding [UNKNOWN]
    'de novo' protein folding [IC]
    B cell cytokine production [UNKNOWN]
    positive regulation of T cell mediated immune response to tumor cell [UNKNOWN]
    positive regulation of interleukin-12 production [UNKNOWN]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN]
    positive regulation of apoptosis [UNKNOWN]
    response to lipopolysaccharide [IEP]
    positive regulation of interleukin-10 production [UNKNOWN]
    positive regulation of interleukin-6 production [UNKNOWN]
    protein stabilization [UNKNOWN]
    isotype switching to IgG isotypes [UNKNOWN]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    insulin binding [IPI]
    p53 binding [UNKNOWN]
    protein binding [UNKNOWN][IEA][IPI]
    protein heterodimerization activity [IPI]
    chaperone binding [UNKNOWN]
    protease binding [IPI]
    cell surface binding [UNKNOWN]
    protein complex binding [IPI]
    misfolded protein binding [IPI]
    lipopolysaccharide binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRLPTVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR  60
   61 TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA 120
  121 RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK 180
  181 DIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ 240
  241 DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV 300
  301 KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQAH DLGKVGEVIV TKDDAMLLKG 360
  361 KGDKAHIEKR IQEITEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR 420
  421 VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLKPANED QKIGIEIIKR ALKIPAMTIA 480
  481 KNAGVEGSLI VEKILQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT 540
  541 TAEAVVTEIP KEEKDPGMGA MGGMGGGMGG GMF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle