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Protein Overview: BRN1

General Information:
Name(s) found: BRN1 / YBL097W [SGD]
Description(s) found:
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  • gi|41629672|ref|NP_009455.2| Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics; Brn1p [Saccharomyces c [NCBI NR]
  • gi|114152787|sp|P38170.2|CND2_YEAST RecName: Full=Condensin complex subunit 2; AltName: Full=Barren homolog; AltName: Full=CAPH homolog [NCBI NR]
  • Condensin complex subunit 2 OS=Saccharomyces cerevisiae GN=BRN1 PE=1 SV=2 [Swiss-Prot]
  • BRN1 Functional homologue of human BRRN1 [mips]
  • Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission [SGD]
  • BRN1 SGDID:S0000193, Chr II from 40828-43092, Verified ORF [yeastflysequest.fasta]
  • Brn1p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • BRN1 SGDID:S000000193, Chr II from 40828-43092, Verified ORF, "Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission an [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • BRN1 SGDID:S000000193, Chr II from 40828-43092, Verified ORF, "Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission" [yeast-200209-contam.fasta]
  • Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics; Brn1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Condensin complex subunit 2 (Barren homolog) (CAPH homolog) [nr-271106-contam.fasta]
  • BRN1 SGDID:S000000193, Chr II from 40828-43092, Verified ORF, "Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 754 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear condensin complex [IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: mitotic chromosome condensation [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTQLRYENN DDDERVEYNL FTNRSTMMAN FEEWIKMATD NKINSRNSWN FALIDYFYDL  60
   61 DVLKDGENNI NFQKASATLD GCIKIYSSRV DSVTTETGKL LSGLAQRKTN GASNGDDSNG 120
  121 GNGEGLGGDS DEANIEIDPL TGMPISNDPD VNNTRRRVYN RVLETTLVEF ETIKMKELDQ 180
  181 ELIIDPLFKK ALVDFDEGGA KSLLLNTLNI DNTARVIFDA SIKDTQNVGQ GKLQRKEEEL 240
  241 IERDSLVDDE NEPSQSLIST RNDSTVNDSV ISAPSMEDEI LSLGMDFIKF DQIAVCEISG 300
  301 SIEQLRNVVE DINQAKDFIE NVNNRFDNFL TEEELQAAVP DNAEDDSDGF DMGMQQELCY 360
  361 PDENHDNTSH DEQDDDNVNS TTGSIFEKDL MAYFDENLNR NWRGREHWKV RNFKKANLVN 420
  421 KESDLLEETR TTIGDTTDKN TTDDKSMDTK KKHKQKKVLE IDFFKTDDSF EDKVFASKGR 480
  481 TKIDMPIKNR KNDTHYLLPD DFHFSTDRIT RLFIKPAQKM SLFSHRKHTR GDVSSGLFEK 540
  541 STVSANHSNN DIPTIADEHF WADNYERKEQ EEKEKEQSKE VGDVVGGALD NPFEDDMDGV 600
  601 DFNQAFEGTD DNEEASVKLD LQDDEDHKFP IRENKVTYSR VSKKVDVRRL KKNVWRSINN 660
  661 LIQEHDSRKN REQSSNDSET HTEDESTKEL KFSDIIQGIS KMYSDDTLKD ISTSFCFICL 720
  721 LHLANEHGLQ ITHTENYNDL IVNYEDLATT QAAS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRN1 SMC2 SMC4
    View Details Krogan NJ, et al. (2006) BRN1 HIS2 SMC2 SMC4 YCG1 YCS4
    View Details Qiu et al. (2008) BRN1 HSK3 SMC2 SMC4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 BRN1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BRN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] deduced N/A No confident structure predictions are available.
    2 View Details [236..387] deduced N/A No confident structure predictions are available.
    3 View Details [388..504] deduced N/A No confident structure predictions are available.
    4 View Details [505..630] deduced N/A No confident structure predictions are available.
    5 View Details [631..754] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle