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Protein Overview: CE36012

General Information:
Name(s) found: CE36012 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00020292 locus:nep-19 status:Partially_confirmed UniProt:O16651 protein_id:CCD69651.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 743 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    neprilysin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIKDTLASP KFQLMASLIF FIAGVTALVI TIIAISSDKK SEQPPPILPS HTEALKAPAP  60
   61 VTTSRPPNLT TSTLPNSSSR PPSIPICDTP ECVTLAHQLL NYRDISVDPC ENFEKSACGK 120
  121 FRENSLNSNV HRSKIFIPRM IKKFLRKNET STSKSENTLR LLYRKCEQYA TVVSVRVGDN 180
  181 DDHEEAYQLI FNKIQSIGSC PLLNGTWDAS KFNLNGIKAL IIFFYNIITD MLLKIAEIGF 240
  241 TNFGFFEISQ MRKPLLTTDS IEKMLFSLSD ANYHDLDDDL VSDYAKEVEK LDVELKKTIF 300
  301 KDNPVDENQP KTLDTLKTFV PSIDFERLIK SFINPKNSKK EQMLKSSPTE RFHLNILFFS 360
  361 VKREINFQLE TIIKKTPPNV LANYLVLKFL TESVEEFIKK NSTALCEEIV MEKLDYAAFR 420
  421 VYYQNYFDKE NLQIVSDMID DTKKNFIEMI QESTWLHEST KKSAIRKVEA MKKIVGYPQE 480
  481 FTPPGTLDKL FENIDTSPAD SFITLLQKIK RFNLELRMAY VSGESELNLK RALLQVNAMY 540
  541 VPHENLMQMF APYMSTPHFD STYPDYAKLA TIGMVIGHEM GHGFDTRGGE YDENGMRNNW 600
  601 WTDENKKLYK KKVGCLVEQY NAYDDPELGK NLTGSKVKHE LIADGFGAEV AWKAYKKLDL 660
  661 SKQPRLIGFQ DFNVDKLFFY IRALKFFGNE IPEKQKPRRL EKATHPTHSF RINGVVSNWK 720
  721 PFAETFNCPV GSPMNPEKKC ELF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] deduced N/A No confident structure predictions are available.
    2 View Details [82..743] PSI-BLAST 1000.0 Neutral endopeptidase (neprilysin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity, acting on L-amino acid peptides
    		•  3.85190688399485 bayes_pls_golite062009
  • peptidase activity
    		•  3.61797750040144 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.22757426039234 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.06983777135542 bayes_pls_golite062009
  • hydrolase activity
    		•  2.61181165622708 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  2.54952091441017 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  2.40931483220122 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.71636138555452 bayes_pls_golite062009
  • receptor activity
    		•  1.71573921458029 bayes_pls_golite062009
  • peptide binding
    		•  1.58227634414618 bayes_pls_golite062009
  • binding
    		•  1.55761777216628 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • receptor binding
    		•  1.27935560429326 bayes_pls_golite062009
  • protein complex binding
    		•  1.16270782056592 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • peptide receptor activity, G-protein coupled
    		•  0.597899738932066 bayes_pls_golite062009
  • peptide receptor activity
    		•  0.574641388356132 bayes_pls_golite062009
  • protein binding
    		•  0.530727556830171 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.364756038518376 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.21808506596674 bayes_pls_golite062009
  • integrin binding
    		•  0.17951252414368 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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