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View Structure Prediction Details

Protein: CE36012
Organism: Caenorhabditis elegans
Length: 743 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE36012.

Description E-value Query
Range
Subject
Range
gi|67810531 - gi|67810531|gb|AAY81997.1| endothelin-converting enzyme-1a [Mus musculus]
684.0 [0..48] [743..47]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIKDTLASP KFQLMASLIF FIAGVTALVI TIIAISSDKK SEQPPPILPS HTEALKAPAP  60
   61 VTTSRPPNLT TSTLPNSSSR P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [82-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSIPICDTPE CVTLAHQLLN YRDISVDPCE NFEKSACGKF RENSLNSNVH RSKIFIPRMI  60
   61 KKFLRKNETS TSKSENTLRL LYRKCEQYAT VVSVRVGDND DHEEAYQLIF NKIQSIGSCP 120
  121 LLNGTWDASK FNLNGIKALI IFFYNIITDM LLKIAEIGFT NFGFFEISQM RKPLLTTDSI 180
  181 EKMLFSLSDA NYHDLDDDLV SDYAKEVEKL DVELKKTIFK DNPVDENQPK TLDTLKTFVP 240
  241 SIDFERLIKS FINPKNSKKE QMLKSSPTER FHLNILFFSV KREINFQLET IIKKTPPNVL 300
  301 ANYLVLKFLT ESVEEFIKKN STALCEEIVM EKLDYAAFRV YYQNYFDKEN LQIVSDMIDD 360
  361 TKKNFIEMIQ ESTWLHESTK KSAIRKVEAM KKIVGYPQEF TPPGTLDKLF ENIDTSPADS 420
  421 FITLLQKIKR FNLELRMAYV SGESELNLKR ALLQVNAMYV PHENLMQMFA PYMSTPHFDS 480
  481 TYPDYAKLAT IGMVIGHEMG HGFDTRGGEY DENGMRNNWW TDENKKLYKK KVGCLVEQYN 540
  541 AYDDPELGKN LTGSKVKHEL IADGFGAEVA WKAYKKLDLS KQPRLIGFQD FNVDKLFFYI 600
  601 RALKFFGNEI PEKQKPRRLE KATHPTHSFR INGVVSNWKP FAETFNCPVG SPMNPEKKCE 660
  661 LF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1dmtA
Description: Neutral endopeptidase (neprilysin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity, acting on L-amino acid peptides 3.85190688399485 bayes_pls_golite062009
peptidase activity 3.61797750040144 bayes_pls_golite062009
metallopeptidase activity 3.22757426039234 bayes_pls_golite062009
endopeptidase activity 3.06983777135542 bayes_pls_golite062009
hydrolase activity 2.61181165622708 bayes_pls_golite062009
metalloendopeptidase activity 2.54952091441017 bayes_pls_golite062009
G-protein coupled receptor activity 2.40931483220122 bayes_pls_golite062009
transmembrane receptor activity 1.71636138555452 bayes_pls_golite062009
receptor activity 1.71573921458029 bayes_pls_golite062009
peptide binding 1.58227634414618 bayes_pls_golite062009
binding 1.55761777216628 bayes_pls_golite062009
signal transducer activity 1.42071856700201 bayes_pls_golite062009
molecular transducer activity 1.42071856700201 bayes_pls_golite062009
receptor binding 1.27935560429326 bayes_pls_golite062009
protein complex binding 1.16270782056592 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
peptide receptor activity, G-protein coupled 0.597899738932066 bayes_pls_golite062009
peptide receptor activity 0.574641388356132 bayes_pls_golite062009
protein binding 0.530727556830171 bayes_pls_golite062009
exopeptidase activity 0.364756038518376 bayes_pls_golite062009
aminopeptidase activity 0.21808506596674 bayes_pls_golite062009
integrin binding 0.17951252414368 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle