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Protein Overview: eft-4

General Information:
Name(s) found: eft-4 / CE33155 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00001169 locus:eef-1A.2 status:Confirmed UniProt:G8JY74 protein_id:CCD68027.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article][IEALink to PubMed article]
    intracellular [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    selenocysteine incorporation [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    translational elongation [IEALink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: GTP binding [IEALink to PubMed article]
    RNA binding [IEALink to PubMed article]
    translation elongation factor activity [IEALink to PubMed article]
    GTPase activity [IEALink to PubMed article]
    translation factor activity, nucleic acid binding [ISSLink to PubMed article]
    transferase activity, transferring phosphorus-containing groups [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKEKVHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAQEMG KGSFKYAWVL  60
   61 DKLKAERERG ITIDIALWKF ETAKYYITII DAPGHRDFIK NMITGTSQAD CAVLVVACNK 120
  121 MDSTEPPFSE ARFTEITNEV SGFIKKIGYN PKAVPFVPIS GFNGDNMLEV SSNMPWFKGW 180
  181 AVERKEGNAS GKTLLEALDS IIPPQRPTDR PLRLPLQDVY KIGGIGTVPV GRVETGIIKP 240
  241 GMVVTFAPQN VTTEVKSVEM HHESLPEAVP GDNVGFNVKN VSVKDIRRGS VCSDSKQDPA 300
  301 KEARTFHAQV IIMNHPGQIS NGYTPVLDCH TAHIACKFNE LKEKVDRRTG KKVEDFPKFL 360
  361 KSGDAGIVEL IPTKPLCVES FTDYAPLGRF AVRDMRQTVA VGVIKSVEKS DGSSGKVTKS 420
  421 AQKAAPKKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered No Comments Cheeseman, I.M., et al. (2004)
    View Run None Entered No Comments Cheeseman, I.M., et al. (2004)
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..429] PSI-BLAST 138.0 Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation elongation factor activity
    		•  8.90683166637832 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  4.8378725567094 bayes_pls_golite062009
  • translation regulator activity
    		•  4.79814772079421 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  4.56509805974548 bayes_pls_golite062009
  • structural molecule activity
    		•  3.58406348799895 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55157966585974 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • translation release factor activity
    		•  2.49148102494524 bayes_pls_golite062009
  • translation termination factor activity
    		•  2.46464632547226 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.39629638016861 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.39600931083427 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.36051733655256 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.35906629925754 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.35679406876731 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.24901251684901 bayes_pls_golite062009
  • actin filament binding
    		•  2.1683792904715 bayes_pls_golite062009
    		• 2.15810909411803 bayes_pls_golite062009
  • motor activity
    		•  2.11140484670646 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.65609907941094 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • actin binding
    		•  1.42666717383185 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.35938517416356 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.33993901826495 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.3182108176243 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • ATP binding
    		•  0.98146619596929 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.949788783884952 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.931486373329219 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • peptidyltransferase activity
    		•  0.705667095586631 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.704934361725919 bayes_pls_golite062009
  • kinase activity
    		•  0.691112783105676 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.6022754485555 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.499834566483656 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  0.353150780751661 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.282397764628576 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.222424272323909 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.12168417344278 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0716139935283535 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0430764033739892 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0397092337273124 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.0378638259240902 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0364322017534667 bayes_pls_golite062009
  • peptide transporter activity
    		•  0.0135927378126404 bayes_pls_golite062009
  • signal sequence binding
    		•  6.53725193420218E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle