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Protein Overview: cul-2

General Information:
Name(s) found: cul-2 / CE32776 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00000837 locus:cul-2 Cullin-2 status:Partially_confirmed UniProt:Q17390 protein_id:CAD18893.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 791 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: anterior/posterior axis specification, embryo [IMPLink to PubMed article]
    meiotic spindle elongation [IMPLink to PubMed article]
    cyclin catabolic process [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    germ-line stem cell division [IMPLink to PubMed article]
    sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation [IMPLink to PubMed article]
    cell cycle [IEALink to PubMed article]
    meiotic anaphase II [IMPLink to PubMed article]
    asymmetric protein localization [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSTKVSLR RPPRPQVMYS LKPKVVEFDK VWVQLRPSII DIINLRPITN VQWHHKFSDV  60
   61 YDICVSIPTP LSERLYNEVK ACIQEHVRQK RQDIVDVDPD LLLQEYHKMW RVFHEGAIFI 120
  121 HRLFGYLNKQ FVKQKRCTDL DNFAQYAAFL QIPDVKEIGC LALEIWKEDL VKTILPQLVK 180
  181 LLLIAIDNDR KGNFPHIANE VSGVINSFVK MEETDFDVVP AEGARYKARE STTAFYQESF 240
  241 EKPLLTDTEQ YYSALAQKML TDLSCSEYME QVIVLLEQEE MRAKKYLHES SVEKVITLCQ 300
  301 KVMIKAHKDK LHAVCHDLIT NEENKDLRNM YRLLKPIQAG LSVMVKEFEE YVKKKGLEAV 360
  361 SRLTGENVPQ QFVENVLRVY NKFNDMKTAV FMDDGEFSSG LDKALQGVVN SKEPGQSVPK 420
  421 ASERLARYTD GLLKKSTKGL SETDLEAKLD SAIVIFRYIE DKDIFQKFYS KMLANRLIAS 480
  481 TSISMDAEEL MINKLKQACG YEFTSKLSRM FTDIGLSQEL SNNFDKHIAD IKTVQPDVKF 540
  541 VPTQTMILQA GSWPLNAPQL STNSNNQTAQ DVANFHLPRI LQPVIQEFEK FYTGKHNGRK 600
  601 LTWLFNMSQG DVRLTYLDKQ YVAQMYVYQM AALLCFERRD AILVKDIGEE IGVSGDYLLK 660
  661 TIRTILDVTL LTCDDQNLTA DSLVRLNMSM TSKRMKFRLQ APQVNKAVEK EQEAVANTVS 720
  721 QDRKYYMECA IVRIMKTRKV LKHNALVTEI MDQTKGRFSP DVPFIKKSIE DLIEKMYIQR 780
  781 TDQNDEYQYL A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..791] PSI-BLAST 1000.0 Crystal Structure of The Cand1-Cul1-Roc1 Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.95820721075934 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.63704265478699 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.59660059921406 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.32718329074249 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  6.69190468636718 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.76121492612224 bayes_pls_golite062009
  • ligase activity
    		•  4.08678005991666 bayes_pls_golite062009
  • transcription factor activity
    		•  3.7855017556511 bayes_pls_golite062009
  • binding
    		•  2.45185337633142 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • transcription activator activity
    		•  2.05043065144612 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54797684894025 bayes_pls_golite062009
  • DNA binding
    		•  1.42215436462553 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.23862224095769 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • transcription factor binding
    		•  0.612315945412079 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • catalytic activity
    		•  0.351553138703956 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.146182977030285 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.117670813298683 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0102780098866235 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle