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Protein Overview: cul-2

General Information:
Name(s) found: cul-2 / CE32775 [WormBase]
Description(s) found:
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  • WBGene00000837 locus:cul-2 Cullin-2 status:Confirmed UniProt:Q17390 protein_id:CAB07302.3 [WormBase]
  • gi|71997515|ref|NP_001023007.1| CULlin family member (cul-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|25815093|emb|CAB07302.3| C. elegans protein ZK520.4b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • Hypothetical protein ZK520.4b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Confirmed TR:O46021 protein_id:CAB07302.3 [wormpep150.fasta]
  • 32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Partially_confirmed TR:O46021 protein_id:CAB07302.3 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Partially_confirmed TR:O46021 protein_id:CAB07302.3 [wormpep132.fasta]
  • 32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Confirmed TR:O46021 protein_id:CAB07302.3 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:cul-2 Cullin family (2 domains) status:Partially_confirmed TR:O46021 protein_id:CAB07302.3 [wormpep115.fasta.reversed]
  • CE32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Confirmed UniProt:O46021_CAEEL protein_id:CAB07302.3 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Confirmed UniProt:O46021_CAEEL protein_id:CAB07302.3| [wormORF-contam.fasta]
  • CULlin family member (cul-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE32775 WBGene00000837 locus:cul-2 Cullin family (2 domains) status:Confirmed UniProt:Q17390 protein_id:CAB07302.3 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE32775 WBGene00000837 locus:cul-2 status:Confirmed UniProt:Q17390 protein_id:CAB07302.3 Cullin-2 [wormpep246-ecoli-contam.fasta]
  • Isoform of Q17390, Isoform 3 of Cullin-2 OS=Caenorhabditis elegans GN=cul-2 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 774 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: anterior/posterior axis specification, embryo [IMPLink to PubMed article]
    meiotic spindle elongation [IMPLink to PubMed article]
    cyclin catabolic process [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    germ-line stem cell division [IMPLink to PubMed article]
    sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation [IMPLink to PubMed article]
    cell cycle [IEALink to PubMed article]
    meiotic anaphase II [IMPLink to PubMed article]
    asymmetric protein localization [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSLKPKVVE FDKVWVQLRP SIIDIINLRP ITNVQWHHKF SDVYDICVSI PTPLSERLYN  60
   61 EVKACIQEHV RQKRQDIVDV DPDLLLQEYH KMWRVFHEGA IFIHRLFGYL NKQFVKQKRC 120
  121 TDLDNFAQYA AFLQIPDVKE IGCLALEIWK EDLVKTILPQ LVKLLLIAID NDRKGNFPHI 180
  181 ANEVSGVINS FVKMEETDFD VVPAEGARYK ARESTTAFYQ ESFEKPLLTD TEQYYSALAQ 240
  241 KMLTDLSCSE YMEQVIVLLE QEEMRAKKYL HESSVEKVIT LCQKVMIKAH KDKLHAVCHD 300
  301 LITNEENKDL RNMYRLLKPI QAGLSVMVKE FEEYVKKKGL EAVSRLTGEN VPQQFVENVL 360
  361 RVYNKFNDMK TAVFMDDGEF SSGLDKALQG VVNSKEPGQS VPKASERLAR YTDGLLKKST 420
  421 KGLSETDLEA KLDSAIVIFR YIEDKDIFQK FYSKMLANRL IASTSISMDA EELMINKLKQ 480
  481 ACGYEFTSKL SRMFTDIGLS QELSNNFDKH IADIKTVQPD VKFVPTQTMI LQAGSWPLNA 540
  541 PQLSTNSNNQ TAQDVANFHL PRILQPVIQE FEKFYTGKHN GRKLTWLFNM SQGDVRLTYL 600
  601 DKQYVAQMYV YQMAALLCFE RRDAILVKDI GEEIGVSGDY LLKTIRTILD VTLLTCDDQN 660
  661 LTADSLVRLN MSMTSKRMKF RLQAPQVNKA VEKEQEAVAN TVSQDRKYYM ECAIVRIMKT 720
  721 RKVLKHNALV TEIMDQTKGR FSPDVPFIKK SIEDLIEKMY IQRTDQNDEY QYLA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..774] PSI-BLAST 1000.0 Crystal Structure of The Cand1-Cul1-Roc1 Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.47178230940453 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.15192834197166 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.12051073361876 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  6.87003086224111 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  6.55844152294696 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.76121492612224 bayes_pls_golite062009
  • transcription factor activity
    		•  3.7855017556511 bayes_pls_golite062009
  • ligase activity
    		•  3.66453881539688 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • binding
    		•  2.3219000606044 bayes_pls_golite062009
  • protein binding
    		•  2.20237620151495 bayes_pls_golite062009
  • transcription activator activity
    		•  2.05043065144612 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54797684894025 bayes_pls_golite062009
  • DNA binding
    		•  1.42215436462553 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.23862224095769 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • transcription factor binding
    		•  0.612315945412079 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • catalytic activity
    		•  0.201606344181603 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.146182977030285 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.117670813298683 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0102780098866235 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle