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Protein Overview: cel-1

General Information:
Name(s) found: cel-1 / CE32300 [WormBase]
Description(s) found:
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  • WBGene00000466 locus:cel-1 mRNA-capping enzyme status:Confirmed UniProt:Q17607 protein_id:CAA99765.2 [WormBase]
  • gi|71980521|ref|NP_001020979.1| mRNA Capping Enzyme Like family member (cel-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|30923301|sp|Q17607.2|MCE1_CAEEL RecName: Full=mRNA-capping enzyme; Includes: RecName: Full=Polynucleotide 5'-triphosphatase; AltName: Full=mRNA 5'-triphosphatase; Short=TPase; Includes: RecName: Full=mRNA guanylyltransferase; AltName: Full=GTP--RNA gua [NCBI NR]
  • gi|25004890|emb|CAA99765.2| C. elegans protein C03D6.3a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • mRNA-capping enzyme OS=Caenorhabditis elegans GN=cel-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep104.fasta]
  • Hypothetical protein C03D6.3a [Caenorhabditis elegans]gi|30923301|sp|Q17607|MCE1_CAEEL mRNA capping enzyme [Includes: Polynucleotide 5'-triphosphatase (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (GTP--RNA guanylyltransferase) (GTase)] [nrdb_11152004_Chlamydomonas]
  • CE32300 WBGene00000466 locus:cel-1 mRNA capping enzyme status:Confirmed SW:Q17607 protein_id:CAA99765.2 [wormpep150.fasta]
  • 32300 WBGene00000466 locus:cel-1 mRNA capping enzyme status:Confirmed SW:Q17607 protein_id:CAA99765.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • locus:cel-1 mRNA capping enzyme status:Confirmed SW:Q17607 protein_id:CAA99765.2 [wormpep115.fasta.reversed]
  • CE32300 WBGene00000466 locus:cel-1 mRNA capping enzyme status:Confirmed UniProt:Q17607 protein_id:CAA99765.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE32300 WBGene00000466 locus:cel-1 mRNA capping enzyme status:Confirmed UniProt:Q17607 protein_id:CAA99765.2| [wormORF-contam.fasta]
  • mRNA capping enzyme [Includes: Polynucleotide 5'-triphosphatase (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (GTP--RNA guanylyltransferase) (GTase)] [nr-271106-contam.fasta]
  • Hypothetical protein C03D6.3a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • mRNA Capping Enzyme Like family member (cel-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE32300 WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q17607 protein_id:CAA99765.2 mRNA-capping enzyme [wormpep246-ecoli-contam.fasta]
  • CE32300 WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q17607 protein_id:CAA99765.2 mRNA guanylyltransferase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 623 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: DNA repair [IEALink to PubMed article]
    molting cycle, protein-based cuticle [IMPLink to PubMed article]
    mRNA capping [IEALink to PubMed article][ISSLink to PubMed article]
    DNA replication [IEALink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    DNA recombination [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    mRNA processing [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    DNA ligase (ATP) activity [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    RNA-dependent ATPase activity [ISSLink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    mRNA guanylyltransferase activity [IEALink to PubMed article]
    protein tyrosine/serine/threonine phosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRGPTPDK ARMGLPDRWL HCPKTGTLIN NLFFPFKTPL CKMYDNQIAE RRYQFHPAEV  60
   61 FSHPHLHGKK IGLWIDLTNT DRYYFREEVT EHECIYHKMK MAGRGVSPTQ EDTDNFIKLV 120
  121 QEFHKKYPDR VVGVHCTHGF NRTGFLIAAY LFQVEEYGLD AAIGEFAENR QKGIYKQDYI 180
  181 DDLFARYDPT EDDKILAPEK PDWEREMSIG MSTQIDNGRP STSQQIPATN GNNNQNGNQL 240
  241 SGGGDNSKLF MDGLIRGVKV CEDEGKKSML QAKIKNLCKY NKQGFPGLQP VSLSRGNINL 300
  301 LEQESYMVSW KADGMRYIIY INDGDVYAFD RDNEVFEIEN LDFVTKNGAP LMETLVDTEV 360
  361 IIDKVEINGA MCDQPRMLIY DIMRFNSVNV MKEPFYKRFE IIKTEIIDMR TAAFKTGRLK 420
  421 HENQIMSVRR KDFYDLEATA KLFGPKFVQH VGHEIDGLIF QPKKTKYETG RCDKVLKWKP 480
  481 PSHNSVDFLL KVEKKCKEGM LPEWIGYLFV QNLSDPFGTM KATATLKKYH NKIIECTLLV 540
  541 DNQGRPKEWK FMRERTDKSL PNGLRTAENV VETMVNPVTE TYLIEYVNHA LRVLKRAAAA 600
  601 HRHHQIHQQQ LHEGEPEARR QKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 34.30103 CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
    2 View Details [214..293] FFAS03 1.0 mRNA capping enzyme alpha subunit
    3 View Details [294..559] PSI-BLAST 13.0 New Crystal Structure of Chlorella Virus DNA Ligase-Adenylate
    4 View Details [560..623] PSI-BLAST 42.221849 mRNA capping enzyme alpha subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mRNA guanylyltransferase activity
    		•  8.44951560480445 bayes_pls_golite062009
  • RNA guanylyltransferase activity
    		•  8.02773775185769 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  5.17049957294188 bayes_pls_golite062009
  • ligase activity
    		•  2.32117041900947 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  2.12202868529213 bayes_pls_golite062009
  • DNA ligase activity
    		•  2.10005856611468 bayes_pls_golite062009
  • catalytic activity
    		•  1.98004058504857 bayes_pls_golite062009
  • binding
    		•  1.6492328714954 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36512645572174 bayes_pls_golite062009
  • DNA binding
    		•  1.30570045339175 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  0.353057247533014 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.293080071585386 bayes_pls_golite062009
  • protein binding
    		•  0.244939883018638 bayes_pls_golite062009
  • ATP binding
    		•  0.0764964990255529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.0486642748854728 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.0414617030999805 bayes_pls_golite062009
    3
    Term Confidence Notes
  • mRNA guanylyltransferase activity
    		•  8.90512192081791 bayes_pls_golite062009
  • RNA guanylyltransferase activity
    		•  8.46124967325993 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  5.45528434251369 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.08627215479695 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  2.90848936326491 bayes_pls_golite062009
  • DNA ligase activity
    		•  2.88630907730339 bayes_pls_golite062009
  • ligase activity
    		•  2.7348192562888 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • hydrolase activity
    		•  2.27001407788735 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.6315894906264 bayes_pls_golite062009
  • binding
    		•  1.63149986094272 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39097817404242 bayes_pls_golite062009
  • DNA binding
    		•  1.33524321669723 bayes_pls_golite062009
  • structural molecule activity
    		•  1.32534541097134 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  1.02324195596817 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.996884322431837 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • translation regulator activity
    		•  0.613904794456162 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  0.571203360462711 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.566068090112017 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.477127926059749 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.477127926059749 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.30211828233765 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.287720615514972 bayes_pls_golite062009
  • protein binding
    		•  0.229784545879049 bayes_pls_golite062009
  • ATP binding
    		•  0.17947590671995 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.148991737494582 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138964074823321 bayes_pls_golite062009
    4
    Term Confidence Notes
  • nucleic acid binding
    		•  3.194200758646 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.08627215479695 bayes_pls_golite062009
  • DNA binding
    		•  2.71213098011194 bayes_pls_golite062009
  • binding
    		•  2.63617204791771 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • hydrolase activity
    		•  2.27001407788735 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.6315894906264 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • structural molecule activity
    		•  1.32534541097134 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.996884322431837 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • translation regulator activity
    		•  0.613904794456162 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.566068090112017 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.477127926059749 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.477127926059749 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.30211828233765 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • protein binding
    		•  0.0528188351789111 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.00388708148970557 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle