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View Structure Prediction Details

Protein: cel-1
Organism: Caenorhabditis elegans
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cel-1.

Description E-value Query
Range		 Subject
Range
gi|187035944, gi... - gi|39595113|emb|CAE60150.1| Hypothetical protein CBG03700 [Caenorhabditis briggsae], gi|187035944|em...
gi|157745583 - gi|157745583|ref|XP_001667888.1| Hypothetical protein CBG03700 [Caenorhabditis briggsae AF16]
 370.0 [0..1] [613..1]

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Predicted Domain #1
Region A:
Residues: [1-213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRGPTPDK ARMGLPDRWL HCPKTGTLIN NLFFPFKTPL CKMYDNQIAE RRYQFHPAEV  60
   61 FSHPHLHGKK IGLWIDLTNT DRYYFREEVT EHECIYHKMK MAGRGVSPTQ EDTDNFIKLV 120
  121 QEFHKKYPDR VVGVHCTHGF NRTGFLIAAY LFQVEEYGLD AAIGEFAENR QKGIYKQDYI 180
  181 DDLFARYDPT EDDKILAPEK PDWEREMSIG MST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.30103
Match: 2c46A
Description: CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [214-293] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIDNGRPSTS QQIPATNGNN NQNGNQLSGG GDNSKLFMDG LIRGVKVCED EGKKSMLQAK  60
   61 IKNLCKYNKQ GFPGLQPVSL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 1p16A
Description: mRNA capping enzyme alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mRNA guanylyltransferase activity 8.44951560480445 bayes_pls_golite062009
RNA guanylyltransferase activity 8.02773775185769 bayes_pls_golite062009
guanylyltransferase activity 5.17049957294188 bayes_pls_golite062009
ligase activity 2.32117041900947 bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds 2.12202868529213 bayes_pls_golite062009
DNA ligase activity 2.10005856611468 bayes_pls_golite062009
catalytic activity 1.98004058504857 bayes_pls_golite062009
binding 1.6492328714954 bayes_pls_golite062009
nucleic acid binding 1.36512645572174 bayes_pls_golite062009
DNA binding 1.30570045339175 bayes_pls_golite062009
DNA ligase (ATP) activity 0.353057247533014 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.293080071585386 bayes_pls_golite062009
protein binding 0.244939883018638 bayes_pls_golite062009
ATP binding 0.0764964990255529 bayes_pls_golite062009
adenyl ribonucleotide binding 0.0486642748854728 bayes_pls_golite062009
adenyl nucleotide binding 0.0414617030999805 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [294-559] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRGNINLLEQ ESYMVSWKAD GMRYIIYIND GDVYAFDRDN EVFEIENLDF VTKNGAPLME  60
   61 TLVDTEVIID KVEINGAMCD QPRMLIYDIM RFNSVNVMKE PFYKRFEIIK TEIIDMRTAA 120
  121 FKTGRLKHEN QIMSVRRKDF YDLEATAKLF GPKFVQHVGH EIDGLIFQPK KTKYETGRCD 180
  181 KVLKWKPPSH NSVDFLLKVE KKCKEGMLPE WIGYLFVQNL SDPFGTMKAT ATLKKYHNKI 240
  241 IECTLLVDNQ GRPKEWKFMR ERTDKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.0
Match: 1p8lA
Description: New Crystal Structure of Chlorella Virus DNA Ligase-Adenylate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mRNA guanylyltransferase activity 8.90512192081791 bayes_pls_golite062009
RNA guanylyltransferase activity 8.46124967325993 bayes_pls_golite062009
guanylyltransferase activity 5.45528434251369 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 3.08627215479695 bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds 2.90848936326491 bayes_pls_golite062009
DNA ligase activity 2.88630907730339 bayes_pls_golite062009
ligase activity 2.7348192562888 bayes_pls_golite062009
RNA binding 2.41160981373213 bayes_pls_golite062009
hydrolase activity 2.27001407788735 bayes_pls_golite062009
catalytic activity 2.15370807854636 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
structural constituent of ribosome 1.6315894906264 bayes_pls_golite062009
binding 1.63149986094272 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
1.5765009871268 bayes_pls_golite062009
nucleic acid binding 1.39097817404242 bayes_pls_golite062009
DNA binding 1.33524321669723 bayes_pls_golite062009
structural molecule activity 1.32534541097134 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
DNA ligase (ATP) activity 1.02324195596817 bayes_pls_golite062009
transcription regulator activity 0.996884322431837 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
translation regulator activity 0.613904794456162 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
DNA ligase (NAD+) activity 0.571203360462711 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.566068090112017 bayes_pls_golite062009
RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
mRNA binding 0.4162128308402 bayes_pls_golite062009
sequence-specific DNA binding 0.32084431704638 bayes_pls_golite062009
translation initiation factor activity 0.30211828233765 bayes_pls_golite062009
transcription factor activity 0.298729064067577 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.287720615514972 bayes_pls_golite062009
protein binding 0.229784545879049 bayes_pls_golite062009
ATP binding 0.17947590671995 bayes_pls_golite062009
adenyl ribonucleotide binding 0.148991737494582 bayes_pls_golite062009
adenyl nucleotide binding 0.138964074823321 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [560-623] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPNGLRTAEN VVETMVNPVT ETYLIEYVNH ALRVLKRAAA AHRHHQIHQQ QLHEGEPEAR  60
   61 RQKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 1p16A
Description: mRNA capping enzyme alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.194200758646 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 3.08627215479695 bayes_pls_golite062009
DNA binding 2.71213098011194 bayes_pls_golite062009
binding 2.63617204791771 bayes_pls_golite062009
RNA binding 2.41160981373213 bayes_pls_golite062009
hydrolase activity 2.27001407788735 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
structural constituent of ribosome 1.6315894906264 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
1.5765009871268 bayes_pls_golite062009
structural molecule activity 1.32534541097134 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.15212468568198 bayes_pls_golite062009
exoribonuclease activity 1.10445667068538 bayes_pls_golite062009
transcription regulator activity 0.996884322431837 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.83268201349295 bayes_pls_golite062009
translation regulator activity 0.613904794456162 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.566068090112017 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
RNA polymerase activity 0.477127926059749 bayes_pls_golite062009
mRNA binding 0.4162128308402 bayes_pls_golite062009
sequence-specific DNA binding 0.32084431704638 bayes_pls_golite062009
translation initiation factor activity 0.30211828233765 bayes_pls_golite062009
transcription factor activity 0.298729064067577 bayes_pls_golite062009
protein binding 0.0528188351789111 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.00388708148970557 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle