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Protein Overview: clp-1

General Information:
Name(s) found: clp-1 / CE30486 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00000542 locus:clp-1 Calpain clp-1 status:Confirmed UniProt:P34308 protein_id:CCD63435.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEALink to PubMed article]
    intracellular [IEALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDEEEIIQ KVEVKPDEFN GLIGSIAGNL IRDKVGGAGG DILGGLASNF FGGGGGGGGG  60
   61 GGGGGFGGGN GGFGGGGGGS GGGGGGNNIG SLVGSLIGGG GGGGNYGGGG GNQGGGGGGG 120
  121 FNFNDIGGLI NSMGGGGGGG QRQGGGGGGF GDILGGIGSL IGGGGGGQYN GGGGNVNPNN 180
  181 LNGGMVNVIG NLIGEAAHRF LGVDPGTGRI IGAVAGNVIM GLGGKDNSLG NIGKVILDNI 240
  241 ISGKFRRDVD PFVRPGPDPD RGGGGSGPSP ISPRPTTEPQ DFYELRDQCL ESKRLFEDPQ 300
  301 FLANDSSLFF SKRPPKRVEW LRPGEITREP QLITEGHSRF DVIQGELGDC WLLAAAANLT 360
  361 LKDELFYRVV PPDQSFTENY AGIFHFQFWQ YGKWVDVVID DRLPTSNGEL LYMHSASNNE 420
  421 FWSALLEKAY AKLFGSYEAL KGGTTSEALE DMTGGLTEFI DLKNPPRNLM QMMMRGFEMG 480
  481 SLFGCSIEAD PNVWEAKMSN GLVKGHAYSI TGCRIVDGPN GQTCILRIRN PWGNEQEWNG 540
  541 PWSDNSREWR SVPDSVKQDM GLKFDHDGEF WMSFDDFMRN FEKMEICNLG PDVMDEVYQM 600
  601 TGVKAAGMVW AANTHDGAWV RNQTAGGCRN YINTFANNPQ FRVQLTDSDP DDDDELCTVI 660
  661 FAVLQKYRRN LKQDGLDNVP IGFAVYDAGN NRGRLSKQFF AANKSAMRSA AFINLREMTG 720
  721 RFRVPPGNYV VVPSTFEPNE EAEFMLRVYT NGFIESEEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..256] PSI-BLAST 18.0 No description for 2quaA was found.
    2 View Details [257..759] PSI-BLAST 171.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.19059336788201 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.93596559605971 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.91734319991078 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43328552376748 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • protein binding
    		•  1.92445772322782 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • transporter activity
    		•  1.21845572420504 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19670958990587 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00091316610003 bayes_pls_golite062009
  • signal transducer activity
    		•  0.9347662946007 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.9347662946007 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.484449686814032 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.354062437867002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • DNA binding
    		•  0.306964954191276 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.246369226539662 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.193338880082314 bayes_pls_golite062009
  • tubulin binding
    		•  0.11107511867058 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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