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Protein Overview: lis-1

General Information:
Name(s) found: lis-1 / CE29339 [WormBase]
Description(s) found:
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  • WBGene00003047 locus:lis-1 Lissencephaly-1 homolog status:Confirmed UniProt:Q9NDC9 protein_id:CAB03282.3 [WormBase]
  • gi|9081899|gb|AAF82632.1|AF164430_1 LIS-1 [Caenorhabditis elegans] [NCBI NR]
  • gi|60392621|sp|Q9NDC9.1|LIS1_CAEEL RecName: Full=Lissencephaly-1 homolog; AltName: Full=Pronuclear migration abnormal protein 1 [NCBI NR]
  • gi|18369718|emb|CAB03282.3| C. elegans protein T03F6.5, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17554220|ref|NP_499755.1| LIS-1 (human lissencephaly gene) related family member (lis-1) [Caenorhabditis elegans] [NCBI NR]
  • Lissencephaly-1 homolog OS=Caenorhabditis elegans GN=lis-1 PE=2 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE29339 WBGene00003047 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed SW:Q9NDC9 protein_id:CAB03282.3 [wormpep150.fasta]
  • 29339 WBGene00003047 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed TR:Q9NDC9 protein_id:CAB03282.3 [wormpep130-phg-ecoli-orf-rand.fasta]
  • human LISsencephaly gene related (45.8 kD) (lis-1) [Caenorhabditis elegans]gi|18369718|emb|CAB03282.3| Hypothetical protein T03F6.5 [Caenorhabditis elegans]gi|9081899|gb|AAF82632.1| LIS-1 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE29339 WBGene00003047 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed TR:Q9NDC9 protein_id:CAB03282.3 [wormpep132.fasta]
  • 29339 WBGene00003047 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed SW:Q9NDC9 protein_id:CAB03282.3 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed TR:Q9NDC9 protein_id:CAB03282.3 [wormpep115.fasta.reversed]
  • CE29339 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed TR:O45742 protein_id:CAB03282.3 [wormpep80.hongbin]
  • CE29339 WBGene00003047 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed UniProt:Q9NDC9 protein_id:CAB03282.3 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE29339 WBGene00003047 locus:lis-1 WD domain, G-beta repeats (4 domains) status:Confirmed UniProt:Q9NDC9 protein_id:CAB03282.3| [wormORF-contam.fasta]
  • Lissencephaly-1 homolog (Pronuclear migration abnormal protein 1) [nr-271106-contam.fasta]
  • LIS-1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • LIS-1 (human lissencephaly gene) related family member (lis-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein T03F6.5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE29339 WBGene00003047 locus:lis-1 status:Confirmed UniProt:Q9NDC9 protein_id:CAB03282.3 Lissencephaly-1 homolog [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 404 amino acids

    Gene Ontology:
    Cellular Component: perinuclear region of cytoplasm [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cell cortex [IDALink to PubMed article]
    aster [IDALink to PubMed article]
    kinetochore [IDALink to PubMed article]
    microtubule [IDALink to PubMed article]
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    spindle organization [IMPLink to PubMed article]
    pronuclear migration [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    establishment of mitotic spindle localization [IMPLink to PubMed article]
    locomotion [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitotic centrosome separation [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    engulfment of apoptotic cell [IMPLink to PubMed article]
    microtubule-based movement [IMPLink to PubMed article]
    chiasma assembly [IMPLink to PubMed article]
    spindle assembly [IMPLink to PubMed article]
    establishment of mitotic spindle orientation [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    synaptic vesicle transport [IMPLink to PubMed article]
    synaptic transmission, GABAergic [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSERQKEE INRAIAEYMQ NNGYSESFSV FLKESSLSEN DIKPLGGILE KKWTTVLRLQ  60
   61 RKVNDLESKL QESQREINHG APTRDKRQAA DWIPRPPETQ KLTGHRLPIT RVIFHPLWTI 120
  121 MASCSEDATI KVWDYETGQL ERTLKGHTDA VNDIAIDAAG KQLVSCSSDL SIKLWDFGQT 180
  181 YDCLKSLKGH EHTVSSVTFL PTGDFVLSAS RDHTIKQWDI STGYCVYTFR GHNDWVRMIR 240
  241 ISNDGTLFAS ASLDQTVTVW SFATKSAKLV LRDHEHAVEC VEWAPDTAYT NVTGQQPEGN 300
  301 STHILFSGSR DRSIKAWNIN TGDVLFTLLA HENWVRGLAF HPKGKYLISV ADDKTLRVWE 360
  361 LSAQRCMKAI EAHEHFVSTV AFHQTSPFVI TGSVDMSCKV WECR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..404] PSI-BLAST 97.221849 PAF-AH Holoenzyme: Lis1/Alfa2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dynactin binding
    		•  7.11157019623125 bayes_pls_golite062009
    		• 6.67009948605948 bayes_pls_golite062009
  • dynein heavy chain binding
    		•  6.59987903164261 bayes_pls_golite062009
  • snoRNA binding
    		•  5.79753675747903 bayes_pls_golite062009
  • structural molecule activity
    		•  5.05435272846365 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  4.71992275913384 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  4.33124151198369 bayes_pls_golite062009
  • GTPase activity
    		•  4.02994814377904 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • myosin II binding
    		•  3.56132510021228 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.18628561734369 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  2.10926890165617 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.07597866771866 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • telomerase activity
    		•  1.44665328127499 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • platelet-activating factor acetyltransferase activity
    		•  1.36229564654648 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.21305848427711 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • RNA-directed DNA polymerase activity
    		•  1.10560669001943 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • kinase activity
    		•  0.807669232329985 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.805273887494167 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.707581908546932 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.634547834947756 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • protein kinase activity
    		•  0.544118712921054 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.43316396073854 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • ligase activity
    		•  0.20682813699621 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0803897416817422 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • kinase binding
    		•  0.0366162235750993 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00858004043229577 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle