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Protein Overview: cul-1

General Information:
Name(s) found: cul-1 / CE29089 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00000836 locus:cul-1 Cullin-1 status:Confirmed UniProt:Q17389 protein_id:CAA84695.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 780 amino acids

    Gene Ontology:
    Cellular Component: cullin-RING ubiquitin ligase complex [IEALink to PubMed article]
    Biological Process: regulation of cell division [IMPLink to PubMed article]
    negative regulation of multicellular organism growth [IMPLink to PubMed article]
    DNA repair [IMPLink to PubMed article]
    positive regulation of cell size [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    negative regulation of mitotic cell cycle [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    cell cycle [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: ubiquitin protein ligase binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNSEPRRMT CDSEVVWKKL QDGLDVAYRR ENMAPKDYMT LYTSVYDYCT SITLSTSRRD  60
   61 GEDGRAESST PARTAGADFV GHEMYQRVEE YVKAYVIAVC EKGAELSGED LLKYYTTEWE 120
  121 NFRISSKVMD GIFAYLNRHW IRRELDEGHE NIYMVYTLAL VVWKRNLFND LKDKVIDAML 180
  181 ELIRSERTGS MINSRYISGV VECLVELGVD DSETDAKKDA ETKKLAVYKE FFEVKFLEAT 240
  241 RGFYTQEAAN FLSNGGNVTD YMIKVETRLN QEDDRCQLYL NSSTKTPLAT CCESVLISNQ 300
  301 LDFLQRHFGG LLVDKRDDDL SRMFKLCDRV PNGLDELRKS LENHIAKEGH QALERVAMEA 360
  361 ATDAKLYVKT LLEVHERYQS LVNRSFKNEP GFMQSLDKAA TSFINNNAVT KRAPPQAQLT 420
  421 KSAELLARYC DQLLRKSSKM PDEAELEELQ TKIMVVFKYI DDKDVFSKFY TKMFSKRLIS 480
  481 ELSASDEAEA NFITKLKSMC GYEYTARLSK MVNDTQVSKD LTADFKEKKA DMLGQKSVEF 540
  541 NVLVLSSGSW PTFPTTPITL PQQLSKTIEI FGQFYNEKFN GRRLTWVYSQ SRGEITSTAF 600
  601 PKKYVFTATT AQMCTMLLFN EQDSYTVEQI AAATKMDEKS APAIVGSLIK NLVLKADTEL 660
  661 QKEDEVPMTA TVSLNKAYMN KKVRVDLSKF TMKQDAVRDT ENVQKNVEED RKSVISACIV 720
  721 RIMKTRKRVQ HQQLMTEVIT QLSGRFKPKV EMIKRCIGSL IEKEYMLRTE GQKDLYEYLA 780
  781

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..780] PSI-BLAST 1000.0 Crystal Structure of The Cand1-Cul1-Roc1 Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.95820721075934 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.63704265478699 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.59660059921406 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.32718329074249 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  6.69190468636718 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.76121492612224 bayes_pls_golite062009
  • ligase activity
    		•  4.08678005991666 bayes_pls_golite062009
  • transcription factor activity
    		•  3.7855017556511 bayes_pls_golite062009
  • binding
    		•  2.45185337633142 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • transcription activator activity
    		•  2.05043065144612 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54797684894025 bayes_pls_golite062009
  • DNA binding
    		•  1.42215436462553 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.23862224095769 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • transcription factor binding
    		•  0.612315945412079 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • catalytic activity
    		•  0.351553138703956 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.146182977030285 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.117670813298683 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0102780098866235 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle