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View Structure Prediction Details

Protein: cul-1
Organism: Caenorhabditis elegans
Length: 780 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cul-1.

Description E-value Query
Range
Subject
Range
gi|50733451 - gi|50733451|ref|XP_418878.1| PREDICTED: similar to Cullin homolog 1 (CUL-1) [Gallus gallus]
788.0 [0..2] [780..212]

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Predicted Domain #1
Region A:
Residues: [1-780]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNSEPRRMT CDSEVVWKKL QDGLDVAYRR ENMAPKDYMT LYTSVYDYCT SITLSTSRRD  60
   61 GEDGRAESST PARTAGADFV GHEMYQRVEE YVKAYVIAVC EKGAELSGED LLKYYTTEWE 120
  121 NFRISSKVMD GIFAYLNRHW IRRELDEGHE NIYMVYTLAL VVWKRNLFND LKDKVIDAML 180
  181 ELIRSERTGS MINSRYISGV VECLVELGVD DSETDAKKDA ETKKLAVYKE FFEVKFLEAT 240
  241 RGFYTQEAAN FLSNGGNVTD YMIKVETRLN QEDDRCQLYL NSSTKTPLAT CCESVLISNQ 300
  301 LDFLQRHFGG LLVDKRDDDL SRMFKLCDRV PNGLDELRKS LENHIAKEGH QALERVAMEA 360
  361 ATDAKLYVKT LLEVHERYQS LVNRSFKNEP GFMQSLDKAA TSFINNNAVT KRAPPQAQLT 420
  421 KSAELLARYC DQLLRKSSKM PDEAELEELQ TKIMVVFKYI DDKDVFSKFY TKMFSKRLIS 480
  481 ELSASDEAEA NFITKLKSMC GYEYTARLSK MVNDTQVSKD LTADFKEKKA DMLGQKSVEF 540
  541 NVLVLSSGSW PTFPTTPITL PQQLSKTIEI FGQFYNEKFN GRRLTWVYSQ SRGEITSTAF 600
  601 PKKYVFTATT AQMCTMLLFN EQDSYTVEQI AAATKMDEKS APAIVGSLIK NLVLKADTEL 660
  661 QKEDEVPMTA TVSLNKAYMN KKVRVDLSKF TMKQDAVRDT ENVQKNVEED RKSVISACIV 720
  721 RIMKTRKRVQ HQQLMTEVIT QLSGRFKPKV EMIKRCIGSL IEKEYMLRTE GQKDLYEYLA 780
  781 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1u6gA
Description: Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.95820721075934 bayes_pls_golite062009
small conjugating protein ligase activity 9.63704265478699 bayes_pls_golite062009
acid-amino acid ligase activity 8.59660059921406 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.32718329074249 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 6.69190468636718 bayes_pls_golite062009
transcription regulator activity 4.76121492612224 bayes_pls_golite062009
ligase activity 4.08678005991666 bayes_pls_golite062009
transcription factor activity 3.7855017556511 bayes_pls_golite062009
binding 2.45185337633142 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
transcription activator activity 2.05043065144612 bayes_pls_golite062009
nucleic acid binding 1.54797684894025 bayes_pls_golite062009
DNA binding 1.42215436462553 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.23862224095769 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
transcription factor binding 0.612315945412079 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
catalytic activity 0.351553138703956 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.146182977030285 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
structure-specific DNA binding 0.117670813298683 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009
sequence-specific DNA binding 0.0102780098866235 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle