Protein Overview: ced-3

General Information:
Name(s) found:	ced-3 / CE29088 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000417 locus:ced-3 Cell death protein 3 status:Confirmed UniProt:P42573 protein_id:CAB61001.2 [WormBase] gi\|6503233\|gb\|AAA27982.2\| cell death protein [Caenorhabditis elegans] [NCBI NR] pir\|\|A49429 interleukin-1 beta-converting enzyme homolog CED-3 - Caenorhabditis elegans [NCBI NR] gi\|19859536\|sp\|P42573.2\|CED3_CAEEL RecName: Full=Cell death protein 3; Contains: RecName: Full=Cell death protein 3 subunit 1; Contains: RecName: Full=Cell death protein 3 subunit 2; Flags: Precursor [NCBI NR] gi\|17539470\|ref\|NP_502538.1\| CEll Death abnormality family member (ced-3) [Caenorhabditis elegans] [NCBI NR] gi\|15718157\|emb\|CAB61001.2\| C. elegans protein C48D1.2, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|11967321\|gb\|AAG42045.1\|AF210702_1 caspase CED-3 [Caenorhabditis elegans] [NCBI NR] Cell death protein 3 OS=Caenorhabditis elegans GN=ced-3 PE=1 SV=2 [Swiss-Prot] [wormpep67.fasta] CE29088 WBGene00000417 locus:ced-3 Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain. status:Confirmed SW:P42573 protein_id:CAB61001.2 [wormpep150.fasta] 29088 WBGene00000417 locus:ced-3 Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain. status:Confirmed SW:P42573 protein_id:CAB61001.2 [wormpep130-phg-ecoli-orf-rand.fasta] cell death protein, Caspase, ICE-like apoptotic protease., CEll Death abnormality CED-3 (56.6 kD) (ced-3) [Caenorhabditis elegans]gi\|15718157\|emb\|CAB61001.2\| Hypothetical protein C48D1.2 [Caenorhabditis elegans]gi\|6503233\|gb\|AAA27982.2\| cell death prote [nrdb_11152004_Chlamydomonas] locus:ced-3 Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain. status:Confirmed SW:P42573 protein_id:CAB61001.2 [wormpep115.fasta.reversed] CE29088 locus:ced-3 Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain. status:Confirmed TR:Q9NAQ8 protein_id:CAB61001.2 [wormpep80.hongbin] CE29088 WBGene00000417 locus:ced-3 Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain. status:Confirmed UniProt:P42573 protein_id:CAB61001.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE29088 WBGene00000417 locus:ced-3 Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain. status:Confirmed UniProt:P42573 protein_id:CAB61001.2\| [wormORF-contam.fasta] CEll Death abnormality family member (ced-3) [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein C48D1.2 [Caenorhabditis elegans] [nr-271106-contam.fasta] caspase CED-3 [Caenorhabditis elegans] [nr-271106-contam.fasta] cell death protein [Caenorhabditis elegans] [nr-271106-contam.fasta] Cell death protein 3 precursor [Contains: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE29088 WBGene00000417 locus:ced-3 status:Confirmed UniProt:P42573 protein_id:CAB61001.2 Cell death protein 3 [wormpep246-ecoli-contam.fasta] CE29088 WBGene00000417 locus:ced-3 status:Confirmed UniProt:P42573 protein_id:CAB61001.2 Cell death protein 3 subunit 1 [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	503 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	cell death [IMP] proteolysis [IEA] apoptosis [IEA] regulation of apoptosis [IEA] cleavage of cytosolic proteins involved in apoptosis [IDA][ISS] programmed cell death [IMP] reproduction [IMP]
Molecular Function:	protein binding [IEA] caspase activity [IDA][IEA] cysteine-type peptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRQDRRSLL ERNIMMFSSH LKVDEILEVL IAKQVLNSDN GDMINSCGTV REKRREIVKA  60
   61 VQRRGDVAFD AFYDALRSTG HEGLAEVLEP LARSVDSNAV EFECPMSPAS HRRSRALSPA 120
  121 GYTSPTRVHR DSVSSVSSFT SYQDIYSRAR SRSRSRALHS SDRHNYSSPP VNAFPSQPSS 180
  181 ANSSFTGCSS LGYSSSRNRS FSKASGPTQY IFHEEDMNFV DAPTISRVFD EKTMYRNFSS 240
  241 PRGMCLIINN EHFEQMPTRN GTKADKDNLT NLFRCMGYTV ICKDNLTGRG MLLTIRDFAK 300
  301 HESHGDSAIL VILSHGEENV IIGVDDIPIS THEIYDLLNA ANAPRLANKP KIVFVQACRG 360
  361 ERRDNGFPVL DSVDGVPAFL RRGWDNRDGP LFNFLGCVRP QVQQVWRKKP SQADILIAYA 420
  421 TTAQYVSWRN SARGSWFIQA VCEVFSTHAK DMDVVELLTE VNKKVACGFQ TSQGSNILKQ 480
  481 MPEMTSRLLK KFYFWPEARN SAV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..304]	PSI-BLAST	29.221849	Structure of the apoptotic protease-activating factor 1 bound to ADP
2	View Details	[305..503]	PSI-BLAST	66.69897	Apopain (caspase-3, cpp32)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: ced-3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: