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View Structure Prediction Details

Protein: ced-3
Organism: Caenorhabditis elegans
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ced-3.

Description E-value Query
Range
Subject
Range
gi|157757559 - gi|157757559|ref|XP_001671123.1| Hypothetical protein CBG01813 [Caenorhabditis briggsae AF16]
gi|39587707, gi|... - gi|39587707|emb|CAE58645.1| Hypothetical protein CBG01813 [Caenorhabditis briggsae], gi|187037907|em...
347.0 [0..2] [503..1]

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Predicted Domain #1
Region A:
Residues: [1-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRQDRRSLL ERNIMMFSSH LKVDEILEVL IAKQVLNSDN GDMINSCGTV REKRREIVKA  60
   61 VQRRGDVAFD AFYDALRSTG HEGLAEVLEP LARSVDSNAV EFECPMSPAS HRRSRALSPA 120
  121 GYTSPTRVHR DSVSSVSSFT SYQDIYSRAR SRSRSRALHS SDRHNYSSPP VNAFPSQPSS 180
  181 ANSSFTGCSS LGYSSSRNRS FSKASGPTQY IFHEEDMNFV DAPTISRVFD EKTMYRNFSS 240
  241 PRGMCLIINN EHFEQMPTRN GTKADKDNLT NLFRCMGYTV ICKDNLTGRG MLLTIRDFAK 300
  301 HESH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.221849
Match: 1z6tA
Description: Structure of the apoptotic protease-activating factor 1 bound to ADP
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [305-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDSAILVILS HGEENVIIGV DDIPISTHEI YDLLNAANAP RLANKPKIVF VQACRGERRD  60
   61 NGFPVLDSVD GVPAFLRRGW DNRDGPLFNF LGCVRPQVQQ VWRKKPSQAD ILIAYATTAQ 120
  121 YVSWRNSARG SWFIQAVCEV FSTHAKDMDV VELLTEVNKK VACGFQTSQG SNILKQMPEM 180
  181 TSRLLKKFYF WPEARNSAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.69897
Match: 1cp3A
Description: Apopain (caspase-3, cpp32)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.24815349282067 bayes_pls_golite062009
protein binding 2.96725373477762 bayes_pls_golite062009
binding 2.91261616137775 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.60103365510479 bayes_pls_golite062009
hydrolase activity 2.51110071893544 bayes_pls_golite062009
cysteine-type peptidase activity 2.37850336421322 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.07426831021634 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.82979469421101 bayes_pls_golite062009
endopeptidase activity 1.58137850574981 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.38256499817012 bayes_pls_golite062009
catalytic activity 1.03907950272772 bayes_pls_golite062009
enzyme regulator activity 0.0737251792690711 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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