Protein Overview: lin-23

General Information:
Name(s) found:	lin-23 / CE28600 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003009 locus:lin-23 F-box\/WD repeat-containing protein lin-23 status:Confirmed UniProt:Q09990 protein_id:CCD66391.1 [WormBase] gi\|20141589\|sp\|Q09990.2\|LIN23_CAEEL RecName: Full=F-box/WD repeat-containing protein lin-23; AltName: Full=Abnormal cell lineage protein 23 [NCBI NR] gi\|17535023\|ref\|NP_495285.1\| abnormal cell LINeage family member (lin-23) [Caenorhabditis elegans] [NCBI NR] gi\|15055400\|gb\|AAA68258.2\| Abnormal cell lineage protein 23 [Caenorhabditis elegans] [NCBI NR] gi\|11055340\|gb\|AAG28037.1\|AF275253_1 LIN-23 [Caenorhabditis elegans] [NCBI NR] F-box/WD repeat-containing protein lin-23 OS=Caenorhabditis elegans GN=lin-23 PE=1 SV=2 [Swiss-Prot] (Q09990) F-box/WD-repeat protein lin-23 [Swiss-Prot] [wormpep67.fasta] CE28600 WBGene00003009 locus:lin-23 Transducin beta chain status:Confirmed SW:Q09990 protein_id:AAA68258.2 [wormpep150.fasta] 28600 WBGene00003009 locus:lin-23 Transducin beta chain status:Confirmed SW:Q09990 protein_id:AAA68258.2 [wormpep130-phg-ecoli-orf-rand.fasta] cell division limitator, a SCF ubiquitin-ligase component., abnormal cell LINeage LIN-23, STerile and Uncoordinated STU-1 (75.9 kD) (lin-23) [Caenorhabditis elegans]gi\|15055400\|gb\|AAA68258.2\| Abnormal cell lineage protein 23 [Caenorhabditis elegans]gi\|1 [nrdb_11152004_Chlamydomonas] locus:lin-23 Transducin beta chain status:Confirmed SW:Q09990 protein_id:AAA68258.2 [wormpep115.fasta.reversed] CE28600 locus:lin-23 Transducin beta chain status:Confirmed SW:Q09990 protein_id:AAA68258.2 [wormpep80.hongbin] CE28600 WBGene00003009 locus:lin-23 Transducin beta chain status:Confirmed UniProt:Q09990 protein_id:AAA68258.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE28600 WBGene00003009 locus:lin-23 Transducin beta chain status:Confirmed UniProt:Q09990 protein_id:AAA68258.2\| [wormORF-contam.fasta] LIN-23 [Caenorhabditis elegans] [nr-271106-contam.fasta] abnormal cell LINeage family member (lin-23) [Caenorhabditis elegans] [nr-271106-contam.fasta] Abnormal cell lineage protein 23 [Caenorhabditis elegans] [nr-271106-contam.fasta] F-box/WD repeat protein lin-23 (Abnormal cell lineage protein 23) [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE28600 WBGene00003009 locus:lin-23 Transducin beta chain status:Confirmed UniProt:Q09990 protein_id:CCD66391.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE28600 WBGene00003009 locus:lin-23 status:Confirmed UniProt:Q09990 protein_id:CCD66391.1 F-box\/WD repeat-containing protein lin-23 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	665 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	negative regulation of multicellular organism growth [IMP ] locomotory behavior [IMP] hermaphrodite genitalia development [IMP] nematode larval development [IMP ] negative regulation of cell proliferation [IMP ] positive regulation of growth rate [IMP] embryonic development ending in birth or egg hatching [IMP ] post-embryonic body morphogenesis [IMP] neuron projection morphogenesis [IMP] growth [IMP]
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPHRASTT QQLADLSLTE GEHDEGKPLS IDYLQGHEGL IEEVLKWSEH EQLDFMDKIV  60
   61 HRLSHYQLGK VDNFIRPMLQ RDFISNLPAH LVELILFNVN SDSLKSCEEV STSWRCALAR 120
  121 GQHWKKLIEK NVRSDSLWWG LSEKRQWDKF LNISRDMSVR RICEKFNYDV NIKRDKLDQL 180
  181 ILMHVFYSKL YPKIIRDIHN IDNNWKRGNY KMTRINCQSE NSKGVYCLQY DDDKIVSGLR 240
  241 DNTIKIWDRK DYSCSRILSG HTGSVLCLQY DNRVIISGSS DATVRVWDVE TGECIKTLIH 300
  301 HCEAVLHLRF ANGIMVTCSK DRSIAVWDMV SPRDITIRRV LVGHRAAVNV VDFDDRYIVS 360
  361 ASGDRTIKVW SMDTLEFVRT LAGHRRGIAC LQYRGRLVVS GSSDNTIRLW DIHSGVCLRV 420
  421 LEGHEELVRC IRFDEKRIVS GAYDGKIKVW DLQAALDPRA LSSEICLCSL VQHTGRVFRL 480
  481 QFDDFQIVSS SHDDTILIWD FLDAPPSGLP SSTNRATLPE LPNQAAVARA QMLFEMAARR 540
  541 EIERRDREVV EEPALRPRAN AARRHNADIA AAAAAAEAAR GAGDNDESSS EEDLDRVDQV 600
  601 NNPNVAGPAP PQPHNQNHRR RQPRPELPVR LMQEMAAFDN MRRQQNNMDH LGGGDVDEEM 660
  661 PDGGP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
hydrolase activity	1.29702012649067	bayes_pls_golite062009
peptidase activity	0.990550688241572	bayes_pls_golite062009
catalytic activity	0.60409960326459	bayes_pls_golite062009

Term	Confidence	Notes
ubiquitin-protein ligase activity	7.6976390971701	bayes_pls_golite062009
small conjugating protein ligase activity	7.38724968585043	bayes_pls_golite062009
acid-amino acid ligase activity	6.41826641115519	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	5.36089569430187	bayes_pls_golite062009
actin binding	3.31804728298431	bayes_pls_golite062009
GTPase activity	3.23750443966606	bayes_pls_golite062009
cytoskeletal protein binding	3.1056443224755	bayes_pls_golite062009
	2.92359149151424	bayes_pls_golite062009
tubulin binding	2.76945430061825	bayes_pls_golite062009
microtubule binding	2.72684103222924	bayes_pls_golite062009
dynein binding	2.54821997913979	bayes_pls_golite062009
binding	2.42570478946173	bayes_pls_golite062009
RNA binding	2.1927334052131	bayes_pls_golite062009
dynactin binding	1.92897254169098	bayes_pls_golite062009
ligase activity	1.82531515493699	bayes_pls_golite062009
nucleic acid binding	1.63776917287392	bayes_pls_golite062009
G-protein-coupled receptor binding	1.63631972867316	bayes_pls_golite062009
transcription regulator activity	1.56901113625383	bayes_pls_golite062009
actin filament binding	1.5197243426595	bayes_pls_golite062009
protein binding	1.21879977456466	bayes_pls_golite062009
transporter activity	1.21549336905926	bayes_pls_golite062009
receptor activity	1.12819778129653	bayes_pls_golite062009
DNA binding	1.0776875611211	bayes_pls_golite062009
microtubule plus-end binding	1.01166033978052	bayes_pls_golite062009
molecular transducer activity	0.974380908248463	bayes_pls_golite062009
signal transducer activity	0.974380908248463	bayes_pls_golite062009
type 1 angiotensin receptor binding	0.920323565472959	bayes_pls_golite062009
angiotensin receptor binding	0.920323565472959	bayes_pls_golite062009
transcription repressor activity	0.826090766828089	bayes_pls_golite062009
substrate-specific transporter activity	0.734793983890004	bayes_pls_golite062009
snoRNA binding	0.637990433340251	bayes_pls_golite062009
transcription factor activity	0.541665384827041	bayes_pls_golite062009
dynein intermediate chain binding	0.443846546939402	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.426429095658617	bayes_pls_golite062009
kinase activity	0.387572734234845	bayes_pls_golite062009
receptor binding	0.316169754698691	bayes_pls_golite062009
transcription corepressor activity	0.259860754265901	bayes_pls_golite062009
structural molecule activity	0.254012051644049	bayes_pls_golite062009
transcription factor binding	0.244641056034795	bayes_pls_golite062009
protein kinase activity	0.229242350006544	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.226335610368636	bayes_pls_golite062009
hydrolase activity	0.181211933860468	bayes_pls_golite062009
histone binding	0.166694897714113	bayes_pls_golite062009
structural constituent of cytoskeleton	0.118975415284669	bayes_pls_golite062009
transcription cofactor activity	0.0160791658499004	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.00585398682921312	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..127]	PSI-BLAST	5.522879	Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
2	View Details	[128..665]	PSI-BLAST	52.522879	Actin interacting protein 1

Protein Overview: lin-23

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: