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Protein Overview: adm-4

General Information:
Name(s) found: adm-4 / CE15265 [WormBase]
Description(s) found:
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  • WBGene00000075 locus:adm-4 status:Partially_confirmed UniProt:Q94316 protein_id:CCD67563.1 [WormBase]
  • pir||T25987 hypothetical protein ZK154.7 - Caenorhabditis elegans [NCBI NR]
  • gi|17548206|ref|NP_509318.1| ADAM (disintegrin plus metalloprotease) family member (adm-4) [Caenorhabditis elegans] [NCBI NR]
  • gi|1572742|gb|AAB09097.1| Adam (disintegrin plus metalloprotease) family protein 4 [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE15265 WBGene00000075 locus:adm-4 metalloprotease status:Partially_confirmed TR:Q94316 protein_id:AAB09097.1 [wormpep150.fasta]
  • 15265 WBGene00000075 locus:adm-4 metalloprotease status:Partially_confirmed TR:Q94316 protein_id:AAB09097.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ADAM (disintegrin plus metalloprotease) protein (adm-4) [Caenorhabditis elegans]gi|1572742|gb|AAB09097.1| Adam (disintegrin plus metalloprotease) family protein 4 [Caenorhabditis elegans]gi|7511002|pir||T25987 hypothetical protein ZK154.7 - Caenorhabdit [nrdb_11152004_Chlamydomonas]
  • locus:adm-4 metalloprotease status:Partially_confirmed TR:Q94316 protein_id:AAB09097.1 [wormpep115.fasta.reversed]
  • CE15265 locus:adm-4 metalloprotease status:Partially_confirmed [wormpep80.hongbin]
  • CE15265 WBGene00000075 locus:adm-4 metalloprotease status:Partially_confirmed UniProt:Q94316_CAEEL protein_id:AAB09097.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE15265 WBGene00000075 locus:adm-4 metalloprotease status:Partially_confirmed UniProt:Q94316_CAEEL protein_id:AAB09097.1| [wormORF-contam.fasta]
  • ZK154.7 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Adam (disintegrin plus metalloprotease) family protein 4 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE15265 WBGene00000075 locus:adm-4 metalloprotease status:Partially_confirmed UniProt:Q94316 protein_id:AAB09097.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE15265 WBGene00000075 locus:adm-4 metalloprotease status:Partially_confirmed UniProt:Q94316 protein_id:CCD67563.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE15265 WBGene00000075 locus:adm-4 status:Partially_confirmed UniProt:Q94316 protein_id:CCD67563.1 [wormpep246-ecoli-contam.fasta]
  • ADAM (Disintegrin plus metalloprotease) family OS=Caenorhabditis elegans GN=adm-4 PE=4 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 686 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    metalloendopeptidase activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIQDRSLLI FLVLGILKSD AFNTRVKRHA PIRFQRSTRQ SVVHFEFLDQ EYVVDLEPNH  60
   61 STFHENFKVF TQDGPQIVPR DEYIGTVREP RAGRAVLTQL EENVYIGSLY FVDDTLHLEP 120
  121 SYPHQLSDDL GPVVGYFESD LDLNLDLSAM PVRNQVSFRR ANPFLKHRRA IAIPSDRRKD 180
  181 VLNVKRNRCT LKLVADYSFY SIFGKNNTGI VTKFLVNMIA RVNEIYTPIN WDVGKEDDIS 240
  241 GRGRFQNMGF SIKEIKVLDR PNASDSHYNS YSRIWEVERL LREFAFAEGS KDFCLVHLVT 300
  301 ARTFREVATL GLAYVSYKKW DETAGGICSK QETFNGRVAY INVLLSTSFA NSEQSTYPLI 360
  361 TKEIDIVVSH EYGHAWGATH DPTIDSDDPD VEECSPNDQN GGKYLMSQYA QKGYDANNVL 420
  421 FSPCSRKLIR DVLIGKWESC FQEEMTSFCG NGIVEDGEEC DNGVDTDNEF NCCDKFCRLA 480
  481 VGAKCSPLNH ICCTPTCQFH NSTHVCLPGD SLLCKADAVC NGFSGECPSA PPVRDGQECL 540
  541 EGGECLNGVC LPFCEKMSIG KKSCICEDLE LSCRLCCRDY NGTCAPVPGH VYLRDGVRCS 600
  601 KGSCRDRKCV NEVVDNVRNY FLITFQTTGG VLEFIKTHIV VIAIIFFTLI FVGIYKIVKY 660
  661 GENFTEKVTH KTAGGCRSVF VKADVN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] MSA 1.195987 View MSA. No confident structure predictions are available.
    2 View Details [172..284] PSI-BLAST 30.0 No description for 2i47A was found.
    3 View Details [285..435] FFAS03 5.89 Crystal structure of the catalytic domain of human ADAM33
    4 View Details [436..594] PSI-BLAST 3.0 No description for 2ao7A was found.
    5 View Details [595..686] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peptidase activity
    		•  4.96061147455283 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.62698381655675 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.84304541762504 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.47603569918171 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  2.59576616298909 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43336263439566 bayes_pls_golite062009
  • receptor binding
    		•  1.66742824145997 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.30802333637213 bayes_pls_golite062009
  • binding
    		•  0.889141120020878 bayes_pls_golite062009
  • catalytic activity
    		•  0.843772148375291 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.392345252967244 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.373706268714699 bayes_pls_golite062009
  • collagen binding
    		•  0.299597363317699 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.253666487713436 bayes_pls_golite062009
  • zinc ion binding
    		•  0.216547007147893 bayes_pls_golite062009
  • protein binding
    		•  0.170370724431219 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.113665386883273 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.00744156656311112 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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