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Protein Overview: CE13307

General Information:
Name(s) found: CE13307 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00020293 locus:nep-20 status:Partially_confirmed UniProt:O16652 protein_id:CCD69652.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 684 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: neprilysin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKKNKRKEK EKERKKAEKF SADEKTANIK DRIINCVYPV ILIILFWLLL FIGARQDEKP  60
   61 SLCESPQCIT LAFELSAYQD TSVSKCHNFY KATCGKYKHH QALDKHRDAK KKEVVKRIVR 120
  121 EFLRRNESSI TSKFEPAIRL MFGKCNKFSQ NKTYLDIFKD IEKIGPWPVL KSDWVDVMFN 180
  181 LNDYLLSLVE LGFTDFGLFK LEFRQLAFGQ FPVIAPSEQK QGNQLEKIIL EILEANGVQA 240
  241 DRQKLSKYLR EYSEFKSQLR HMSLEGTSVK YIRYNASTLS VNISALVQKM APMSTSSGLV 300
  301 RRIQSGILIT NSSSFFGKNL DAIIQQTHKR TLANYLIFHF IDAVTFDLTS GAKHSEHTLI 360
  361 DLLPRGSLQV LSQDFVDEED QGVMVEMAKD LKKHVVEMIS EGSSLDKGHL VFEEKERRKL 420
  421 IRKVQDILVV TKYPLEILNQ NFEKLNLTYS DSLHKIIQKL RRFRSEQLIE YLGGDLDPTD 480
  481 KGMWGSAHYE QATNDLIIIA PIIDGPYFDT SYPNYVNIFF MGFIISRELG RSLDSVRIRK 540
  541 DEKGHTENWL KSESLKRFDN NVKCWRKKIT GTRFLNEMLA DHVGHEASFM ALKKWEKEMN 600
  601 GTIVEKIRGY ESMTMEQIFF HLQALYFCRP PGGSTGELTA KDARQHYSTR VNEAFKNMPQ 660
  661 FAKAFGCSSN QNMNSKTKRF EEHG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..684] PSI-BLAST 163.0 Neutral endopeptidase (neprilysin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • bradykinin receptor binding
    		•  4.68498310889748 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.85190688399485 bayes_pls_golite062009
  • peptidase activity
    		•  3.61797750040144 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.48739595085357 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.22757426039234 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  3.15882456934259 bayes_pls_golite062009
  • hydrolase activity
    		•  2.61181165622708 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  2.54952091441017 bayes_pls_golite062009
  • angiotensin receptor activity
    		•  2.47329778652768 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  2.40931483220122 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.71636138555452 bayes_pls_golite062009
  • receptor activity
    		•  1.71573921458029 bayes_pls_golite062009
  • peptide binding
    		•  1.58227634414618 bayes_pls_golite062009
  • protein binding
    		•  1.58118182554863 bayes_pls_golite062009
  • binding
    		•  1.55761777216628 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42071856700201 bayes_pls_golite062009
  • viral receptor activity
    		•  1.39617252453036 bayes_pls_golite062009
  • epoxide hydrolase activity
    		•  1.37998417474643 bayes_pls_golite062009
  • ether hydrolase activity
    		•  1.18753073809881 bayes_pls_golite062009
  • protein complex binding
    		•  1.16270782056592 bayes_pls_golite062009
  • receptor binding
    		•  1.00224939479086 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  0.997590082412571 bayes_pls_golite062009
  • integrin binding
    		•  0.93449223670512 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • peptide receptor activity, G-protein coupled
    		•  0.597899738932066 bayes_pls_golite062009
  • peptide receptor activity
    		•  0.574641388356132 bayes_pls_golite062009
  • hydrolase activity, acting on ether bonds
    		•  0.457157426475929 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.364756038518376 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.21808506596674 bayes_pls_golite062009
  • chloride ion binding
    		•  0.13359795531295 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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