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Protein Overview: mdh-1

General Information:
Name(s) found: mdh-1 / CE09512 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00003162 locus:mdh-2 Probable malate dehydrogenase, mitochondrial status:Confirmed UniProt:O02640 protein_id:CCD69776.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: malate metabolic process [IEALink to PubMed article]
    cellular carbohydrate metabolic process [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    glycolysis [IEALink to PubMed article]
    tricarboxylic acid cycle intermediate metabolic process [IEALink to PubMed article]
    Molecular Function: L-malate dehydrogenase activity [IEALink to PubMed article]
    malate dehydrogenase activity [IEALink to PubMed article]
    L-lactate dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    malate dehydrogenase (NADP+) activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPAKTLVQ AAANSGLRAV SVRHSSQAPK VALLGAAGGI GQPLGLLLKQ DPLVAHLALY  60
   61 DVVNTPGVAA DLSHIDSNAK VTAHTGPKEL YAAVENADVI VIPAGVPRKP GMTRDDLFNT 120
  121 NAGIVRDLAA VIAKASPKAL IAIITNPVNS TVPIASEVLK KAGVYDPKRV FGVTTLDVVR 180
  181 SQAFVSELKG HDASKTVVPV VGGHAGITII PLLSQVKPST KFSEEEISKL TPRIQDAGTE 240
  241 VVNAKAGAGS ATLSMALAGA RFANALVRGI KGEKNVQCAY VASDAVKGVE YFSTPVELGP 300
  301 NGVEKILGVG KVSAYEQKLI DASVPELNKN IAKGVAFVKG N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 74.522879 Malate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • malate dehydrogenase activity
    		•  7.69241456337154 bayes_pls_golite062009
  • L-malate dehydrogenase activity
    		•  5.35837481826138 bayes_pls_golite062009
  • lactate dehydrogenase activity
    		•  4.66418715735914 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  3.06391460989761 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  3.02758902218302 bayes_pls_golite062009
  • malic enzyme activity
    		•  2.98382582538724 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.75947908917144 bayes_pls_golite062009
  • L-lactate dehydrogenase activity
    		•  2.59062377380589 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.58076782195922 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  2.26153457113968 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.88605255677599 bayes_pls_golite062009
  • binding
    		•  1.76718756313666 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.70038641098437 bayes_pls_golite062009
  • catalytic activity
    		•  1.67029398049886 bayes_pls_golite062009
  • protein binding
    		•  1.47646217957458 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • NAD or NADH binding
    		•  1.02662588361709 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.99118526697655 bayes_pls_golite062009
  • transporter activity
    		•  0.793769336118517 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.788034697021177 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.714637370305282 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.635891484075352 bayes_pls_golite062009
  • coenzyme binding
    		•  0.59785037604907 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.576163737662951 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.439912268968251 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.300373102236296 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.239024094835991 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.216422278300306 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.201915860594054 bayes_pls_golite062009
  • signal transducer activity
    		•  0.201915860594054 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.192594057004213 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.165260811069909 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.136079082491021 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0257250793986203 bayes_pls_golite062009
  • glyoxylate reductase activity
    		•  0.0221984076575323 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  4.92199819939532E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.53

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle