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Protein Overview: dhs-28

General Information:
Name(s) found: dhs-28 / CE04770 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00000991 locus:dhs-28 status:Confirmed UniProt:Q21481 protein_id:CCD70982.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 436 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: estrogen biosynthetic process [IEALink to PubMed article]
    tetrahydrobiopterin biosynthetic process [IEALink to PubMed article]
    poly-hydroxybutyrate biosynthetic process [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    Molecular Function: estradiol 17-beta-dehydrogenase activity [IEALink to PubMed article]
    sepiapterin reductase activity [IEALink to PubMed article]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    3-hydroxybutyrate dehydrogenase activity [IEALink to PubMed article]
    acetoacetyl-CoA reductase activity [IEALink to PubMed article]
    2-deoxy-D-gluconate 3-dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLRFDGKVA IVTGAGGGLG KTYALELAKR GCKVVVNDLG GDRHGTSSSS SMADKVVQEI  60
   61 KSAGGQAVAN YDSVEFGDKI VKTAIDNFGR IDIVINNAGI LRDVSFLKMT ELDWDLIFKV 120
  121 HVKGAYAVTK AAWPYMRDQK YGRIVVTSSN AGVHGNFGQA NYAAAKSALI GLSNSLAQEG 180
  181 AKYNILANTL VPTAGSRLTE TVMPQNLVDA LKPDYVTPLV TYMVHDSFEE SGKVFEAGAG 240
  241 WYGTIQYYKS KGKVISHASA DDIAKNWSTI TNMNGAEYIG TITEQSARLV SILEEHEASS 300
  301 GSSSASSGAS SGGAFPSNIR SSALFQEMAD GVKADPTAVK TLKSIVLYII TDGKNELGKF 360
  361 TLDFKSASPS VYLGDVKNGE KANATVTVAD SDFVDIAAGK LNAQKAFMSG KLKVKGNVML 420
  421 LQKLQTVLEK AKKSKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..300] PSI-BLAST 69.522879 Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
    2 View Details [301..436] PSI-BLAST 33.522879 SCP2-like domain of MFE-2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  3.08644105481774 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  3.06391460989761 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  3.02758902218302 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.27032644348698 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • receptor activity
    		•  1.02559644924534 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.973650203491298 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.90525319208477 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • signal transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.576163737662951 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.439912268968251 bayes_pls_golite062009
  • ethanol binding
    		•  0.43110794057174 bayes_pls_golite062009
  • retinol binding
    		•  0.40116957175133 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.320177384202291 bayes_pls_golite062009
  • DNA binding
    		•  0.302492036575815 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.0913823272876781 bayes_pls_golite062009
  • glyoxylate reductase activity
    		•  0.0221984076575323 bayes_pls_golite062009
    2
    Term Confidence Notes
  • sterol carrier protein X-related thiolase activity
    		•  2.46442588113447 bayes_pls_golite062009
  • binding
    		•  2.42849959483419 bayes_pls_golite062009
    		• 2.41906840457141 bayes_pls_golite062009
  • sterol binding
    		•  2.24666178533847 bayes_pls_golite062009
  • steroid binding
    		•  1.67242619480107 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.86283765215999 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  0.851413098259232 bayes_pls_golite062009
  • lipid binding
    		•  0.675526318441269 bayes_pls_golite062009
  • protein binding
    		•  0.608540786207145 bayes_pls_golite062009
  • catalytic activity
    		•  0.334051377480817 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.0374694704754488 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle