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View Structure Prediction Details

Protein: dhs-28
Organism: Caenorhabditis elegans
Length: 436 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dhs-28.

Description E-value Query
Range
Subject
Range
gi|39586752, gi|... - gi|39586752|emb|CAE65794.1| Hypothetical protein CBG10899 [Caenorhabditis briggsae], gi|187030676|em...
gi|157770314 - gi|157770314|ref|XP_001676977.1| Hypothetical protein CBG10899 [Caenorhabditis briggsae AF16]
350.0 [0..1] [436..1]

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Predicted Domain #1
Region A:
Residues: [1-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLRFDGKVA IVTGAGGGLG KTYALELAKR GCKVVVNDLG GDRHGTSSSS SMADKVVQEI  60
   61 KSAGGQAVAN YDSVEFGDKI VKTAIDNFGR IDIVINNAGI LRDVSFLKMT ELDWDLIFKV 120
  121 HVKGAYAVTK AAWPYMRDQK YGRIVVTSSN AGVHGNFGQA NYAAAKSALI GLSNSLAQEG 180
  181 AKYNILANTL VPTAGSRLTE TVMPQNLVDA LKPDYVTPLV TYMVHDSFEE SGKVFEAGAG 240
  241 WYGTIQYYKS KGKVISHASA DDIAKNWSTI TNMNGAEYIG TITEQSARLV SILEEHEASS 300
  301 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 69.522879
Match: 1zbqA
Description: Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
retinol dehydrogenase activity 3.08644105481774 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 3.06391460989761 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 3.02758902218302 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
steroid dehydrogenase activity 1.75109362865449 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.55012034958204 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 1.27032644348698 bayes_pls_golite062009
fatty acid synthase activity 1.23679054027553 bayes_pls_golite062009
receptor activity 1.02559644924534 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
transmembrane receptor activity 0.973650203491298 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 0.90525319208477 bayes_pls_golite062009
molecular transducer activity 0.832324207538104 bayes_pls_golite062009
signal transducer activity 0.832324207538104 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.604742541607263 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.576163737662951 bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity 0.532187027260366 bayes_pls_golite062009
enoyl-CoA hydratase activity 0.439912268968251 bayes_pls_golite062009
ethanol binding 0.43110794057174 bayes_pls_golite062009
retinol binding 0.40116957175133 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 0.320177384202291 bayes_pls_golite062009
DNA binding 0.302492036575815 bayes_pls_golite062009
transcription regulator activity 0.177044638410302 bayes_pls_golite062009
nucleic acid binding 0.100470710829263 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.0913823272876781 bayes_pls_golite062009
glyoxylate reductase activity 0.0221984076575323 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [301-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSASSGAS SGGAFPSNIR SSALFQEMAD GVKADPTAVK TLKSIVLYII TDGKNELGKF  60
   61 TLDFKSASPS VYLGDVKNGE KANATVTVAD SDFVDIAAGK LNAQKAFMSG KLKVKGNVML 120
  121 LQKLQTVLEK AKKSKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.522879
Match: 1iktA
Description: SCP2-like domain of MFE-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol carrier protein X-related thiolase activity 2.46442588113447 bayes_pls_golite062009
binding 2.42849959483419 bayes_pls_golite062009
2.41906840457141 bayes_pls_golite062009
sterol binding 2.24666178533847 bayes_pls_golite062009
steroid binding 1.67242619480107 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.86283765215999 bayes_pls_golite062009
steroid dehydrogenase activity 0.851413098259232 bayes_pls_golite062009
lipid binding 0.675526318441269 bayes_pls_golite062009
protein binding 0.608540786207145 bayes_pls_golite062009
catalytic activity 0.334051377480817 bayes_pls_golite062009
oxidoreductase activity 0.0374694704754488 bayes_pls_golite062009

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