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Protein Overview: klp-10

General Information:
Name(s) found: klp-10 / CE04148 [WormBase]
Description(s) found:
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  • WBGene00002221 locus:klp-10 status:Confirmed UniProt:G5EE85 protein_id:CCD66567.1 [WormBase]
  • pir||T34149 hypothetical protein C33H5.4 - Caenorhabditis elegans [NCBI NR]
  • gi|71983945|ref|NP_001023044.1| Kinesin-Like Protein family member (klp-10) [Caenorhabditis elegans] [NCBI NR]
  • gi|18146801|dbj|BAB82459.1| kinesin like protein [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_501291.1| kinesin-like protein (77.3 kD) (klp-10C) [Caenorhabditis elegans] [NCBI NR]
  • gi|1086599|gb|AAA82277.1| Kinesin-like protein protein 10, isoform a [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE04148 WBGene00002221 locus:klp-10 status:Confirmed TR:Q18413 protein_id:AAA82277.1 [wormpep150.fasta]
  • 04148 WBGene00002221 locus:klp-10 status:Confirmed TR:Q18413 protein_id:AAA82277.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • kinesin-like protein (77.3 kD) (klp-10C) [Caenorhabditis elegans]gi|1086599|gb|AAA82277.1| Kinesin-like protein protein 10, isoform a [Caenorhabditis elegans]gi|7496960|pir||T34149 hypothetical protein C33H5.4 - Caenorhabditis elegansgi|18146801|dbj|BA [nrdb_11152004_Chlamydomonas]
  • locus:klp-10 status:Confirmed TR:Q18413 protein_id:AAA82277.1 [wormpep115.fasta.reversed]
  • CE04148 locus:klp-10 status:Confirmed [wormpep80.hongbin]
  • CE04148 WBGene00002221 locus:klp-10 status:Confirmed UniProt:Q18413_CAEEL protein_id:AAA82277.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE04148 WBGene00002221 locus:klp-10 status:Confirmed UniProt:Q18413_CAEEL protein_id:AAA82277.1| [wormORF-contam.fasta]
  • Kinesin like protein [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Kinesin-like protein protein 10, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Kinesin-Like Protein family member (klp-10) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE04148 WBGene00002221 locus:klp-10 status:Confirmed UniProt:Q18413 protein_id:AAA82277.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE04148 WBGene00002221 locus:klp-10 status:Confirmed UniProt:G5EE85 protein_id:CCD66567.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
    • Organism: Caenorhabditis elegans
    Length: 690 amino acids

    Gene Ontology:
    Cellular Component: microtubule associated complex [IEALink to PubMed article]
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    microtubule-based movement [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    microtubule motor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQYIKCYGR VRPSARLGAS SESLVVGGRV VTIDTDNGSK RYELHHIFDS SSSQEDVFGT  60
   61 VAKKIVEDCV EGYNGTVFAY GQTGSGKTHT MLGPCDSWTD PELMGLIPRS VEHVFQHLDT 120
  121 KAKKCQKLTF SVSVEFVELY NEVIYDLLNA KNKVQLRDSG KDIQLVGALP KNVDNPLDLM 180
  181 HLVQKGWQER STGSTAMNAE SHALLIIRIK TQERTGELVK ERSSILNLVD LAGSERQTHT 240
  241 KSSGDRLKEA TNINSSLTVL GRCIRLLADP SKAKGHVPYR DSHLTHILKN SLGGNSKTAV 300
  301 IVNMHPDRDF AQESNSTLMF AQSCTMIMNI ATRNEVMTGD QESSYKKAIQ QLRQEKRGKS 360
  361 TANSSSTFEC IALKNQTLQL EIDASEKRYQ ELQKETSALR NRYQENLDAT ILMQTPSAKE 420
  421 RRSSSRPKRR ETQYRPSPAR MALFAEVETS EDAVLDLQCQ NEKLCCELSS LKDKHEEATS 480
  481 KSTETERLLQ GEIVALQKEV SIVSESLRKS EAVAEGYKEK VAANNLTLDK LLLHIDASRK 540
  541 RIAELELSSK ESENRSSEEL EVDELQLSNA TIKKLNADLS TKAGLIRSLE DSIEKKSQMI 600
  601 TRLEEQAVLD SSELSSTKRQ LEHSRLEAIQ WRKISDETTS AMQTQLKDHQ TDIDQCRHKK 660
  661 KSEIQSMQLS LDNANARVKE SEAMMKKTSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..296] PSI-BLAST 85.39794 Kinesin
    2 View Details [297..690] PSI-BLAST 12.0 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.07967285635739 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle