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Protein Overview: sma-6

General Information:
Name(s) found: sma-6 / CE01842 [WormBase]
Description(s) found:
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  • WBGene00004860 locus:sma-6 Serine\/threonine-protein kinase sma-6 status:Confirmed UniProt:Q09488 protein_id:CCD66028.1 [WormBase]
  • pir||T15734 hypothetical protein C32D5.2 - Caenorhabditis elegans [NCBI NR]
  • gi|746465|gb|AAC46790.1| Small protein 6 [Caenorhabditis elegans] [NCBI NR]
  • gi|4219016|gb|AAD12261.1| serine-threonine kinase SMA-6 [Caenorhabditis elegans] [NCBI NR]
  • gi|17532233|ref|NP_495271.1| SMAll family member (sma-6) [Caenorhabditis elegans] [NCBI NR]
  • gi|1353133|sp|Q09488.1|SMA6_CAEEL RecName: Full=Serine/threonine-protein kinase sma-6; Flags: Precursor [NCBI NR]
  • Serine/threonine-protein kinase sma-6 OS=Caenorhabditis elegans GN=sma-6 PE=2 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE01842 WBGene00004860 locus:sma-6 Activin receptor status:Confirmed SW:Q09488 protein_id:AAC46790.1 [wormpep150.fasta]
  • 01842 WBGene00004860 locus:sma-6 Activin receptor status:Confirmed SW:Q09488 protein_id:AAC46790.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • SMAll body size SMA-6, Serine-threonine kinase, transforming growth factor beta type I receptor, Drosophila thickvein/ vertebrate bone morphogenetic protein receptor type I homolog; affects in a dose dependent way body size and the arrangement of peripher [nrdb_11152004_Chlamydomonas]
  • locus:sma-6 Activin receptor status:Confirmed SW:Q09488 protein_id:AAC46790.1 [wormpep115.fasta.reversed]
  • CE01842 locus:sma-6 Activin receptor status:Confirmed [wormpep80.hongbin]
  • CE01842 WBGene00004860 locus:sma-6 Activin receptor status:Confirmed UniProt:SMA6_CAEEL protein_id:AAC46790.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE01842 WBGene00004860 locus:sma-6 Activin receptor status:Confirmed UniProt:SMA6_CAEEL protein_id:AAC46790.1| [wormORF-contam.fasta]
  • Small protein 6 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • SMAll family member (sma-6) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • serine-threonine kinase SMA-6 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase sma-6 precursor [nr-271106-contam.fasta]
  • CE01842 WBGene00004860 locus:sma-6 Activin receptor status:Confirmed UniProt:Q09488 protein_id:AAC46790.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE01842 WBGene00004860 locus:sma-6 Activin receptor status:Confirmed UniProt:Q09488 protein_id:CCD66028.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE01842 WBGene00004860 locus:sma-6 status:Confirmed UniProt:Q09488 protein_id:CCD66028.1 Serine\/threonine-protein kinase sma-6 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 636 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: dauer larval development [IGILink to PubMed articleLink to PubMed article]
    tail tip morphogenesis [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of protein catabolic process [IMPLink to PubMed article]
    regulation of cell adhesion [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    maintenance of protein location in nucleus [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    transforming growth factor beta receptor activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    transmembrane receptor protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP  60
   61 NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 120
  121 SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 180
  181 PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES 240
  241 KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 300
  301 SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT 360
  361 TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL 420
  421 RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV 480
  481 NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG 540
  541 IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 600
  601 EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 9.221849 EGF receptor extracellular domain; EGF receptor Cys-rich domains
    2 View Details [218..636] PSI-BLAST 58.69897 Type I TGF-beta receptor R4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • growth factor binding
    		•  6.33296746316446 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  4.12271516631296 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  3.34170345809493 bayes_pls_golite062009
  • phosphatase activator activity
    		•  3.21710814193653 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  3.21228058881915 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  3.14198260332974 bayes_pls_golite062009
  • protein binding
    		•  3.04595153576805 bayes_pls_golite062009
  • binding
    		•  2.68009303221354 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.11274485218746 bayes_pls_golite062009
  • receptor activity
    		•  2.04770371945982 bayes_pls_golite062009
  • protein kinase activity
    		•  1.82134570765005 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • signal transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.3823186140816 bayes_pls_golite062009
  • kinase activity
    		•  1.33897988039058 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.18258120268925 bayes_pls_golite062009
  • transferase activity
    		•  0.694193657141457 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.625443680166071 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.41080910982871 bayes_pls_golite062009
  • catalytic activity
    		•  0.271811389148807 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.126307392530805 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0323918145169712 bayes_pls_golite062009
    2
    Term Confidence Notes
  • activin receptor activity
    		•  9.43409082112081 bayes_pls_golite062009
  • activin binding
    		•  7.11944534332244 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  6.41728494915949 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  6.1393596497059 bayes_pls_golite062009
  • protein kinase activity
    		•  5.63683237027974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.46123870227889 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.97315540587667 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  2.57601476622612 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • follistatin binding
    		•  2.2292685945544 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  2.00819948109978 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.91768456749814 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.82118598657067 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  1.46877913443522 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.30850950497296 bayes_pls_golite062009
  • amine binding
    		•  1.3051205627964 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • insulin binding
    		•  1.03564126441771 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.969211838627617 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.882469239828589 bayes_pls_golite062009
  • DNA binding
    		•  0.762515260839252 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • transcription factor activity
    		•  0.56681746573603 bayes_pls_golite062009
  • transcription activator activity
    		•  0.488465624367016 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • peptidase activity
    		•  0.36599510639344 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type II
    		•  0.365530951355731 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.34434685718027 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.33253160432275 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • PTB domain binding
    		•  0.216691319543711 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.0805828560158752 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.0123645889643007 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.96656737540424E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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