| Protein: | sma-6 |
| Organism: | Caenorhabditis elegans |
| Length: | 636 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sma-6.
| Description | E-value | Query Range |
Subject Range |
|
|
395.0 | [0..9] | [594..257] |
|
Region A: Residues: [1-217] |
1 11 21 31 41 51
| | | | | |
1 MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP 60
61 NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 120
121 SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 180
181 PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAE
|
| Detection Method: |  |
| Confidence: | 9.221849 |
| Match: | 1ivoA |
| Description: | EGF receptor extracellular domain; EGF receptor Cys-rich domains |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| growth factor binding | 6.33296746316446 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 4.12271516631296 | bayes_pls_golite062009 |
| protein tyrosine phosphatase activator activity | 3.34170345809493 | bayes_pls_golite062009 |
| phosphatase activator activity | 3.21710814193653 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 3.21228058881915 | bayes_pls_golite062009 |
| insulin-like growth factor I binding | 3.14198260332974 | bayes_pls_golite062009 |
| protein binding | 3.04595153576805 | bayes_pls_golite062009 |
| binding | 2.68009303221354 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.11274485218746 | bayes_pls_golite062009 |
| receptor activity | 2.04770371945982 | bayes_pls_golite062009 |
| protein kinase activity | 1.82134570765005 | bayes_pls_golite062009 |
| molecular transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| signal transducer activity | 1.716940423168 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.3823186140816 | bayes_pls_golite062009 |
| kinase activity | 1.33897988039058 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.18258120268925 | bayes_pls_golite062009 |
| transferase activity | 0.694193657141457 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 0.625443680166071 | bayes_pls_golite062009 |
| glycoprotein binding | 0.41080910982871 | bayes_pls_golite062009 |
| catalytic activity | 0.271811389148807 | bayes_pls_golite062009 |
| enzyme activator activity | 0.126307392530805 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.0323918145169712 | bayes_pls_golite062009 |
|
Region A: Residues: [218-636] |
1 11 21 31 41 51
| | | | | |
1 EKSKARARAK TVSLKTESTY MESKSMLEDS GSGSGQAALI QRTVRQDLTI IKTIGQGRYG 60
61 EVRKALYRGS YVAVKTFYTT DEDSWKNERD VYQTNMINHE NILQFVAADI WSEEDSMTKM 120
121 LLITDYHELG SLSDYLCREE TLTTDEALRL IHSCICGIEH LHAAVHGTGS FRKPEIAHRD 180
181 IKSKNIIVKR PNVCCIADLG LALRYQNDKI LPEKFNVQVG TKRYMAPELI SNKLNPKDFS 240
241 QFKMADIYSM ALVMWEVAIR VEVNTCEEVL TVDETSPDHS ASSGIGESVS SSGNISRMHL 300
301 QKTNVEGHST SLKAKQHVPP FDGIVHNDPN FDEMNDVICV RRIRPPPDLA WKNVPALNEL 360
361 SKLMEDSWHS IPHFRHSALK LKKEMAELIK NPDRQNQSQR KVEFQQQDSG LVESATNQS
|
| Detection Method: | |
| Confidence: | 58.69897 |
| Match: | 1b6cB |
| Description: | Type I TGF-beta receptor R4 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| activin receptor activity | 9.43409082112081 | bayes_pls_golite062009 |
| activin binding | 7.11944534332244 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 6.41728494915949 | bayes_pls_golite062009 |
| activin receptor activity, type I | 6.1393596497059 | bayes_pls_golite062009 |
| protein kinase activity | 5.63683237027974 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.04467222534257 | bayes_pls_golite062009 |
| kinase activity | 4.85903980916957 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.46123870227889 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 3.37600307408153 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 3.37600307408153 | bayes_pls_golite062009 |
| transferase activity | 3.26787750561728 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.97315540587667 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 2.57601476622612 | bayes_pls_golite062009 |
| binding | 2.31930216202447 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| follistatin binding | 2.2292685945544 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 2.00819948109978 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| insulin receptor activity | 1.91768456749814 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.82118598657067 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 1.46877913443522 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.30850950497296 | bayes_pls_golite062009 |
| amine binding | 1.3051205627964 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| insulin binding | 1.03564126441771 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| transcription regulator activity | 0.969211838627617 | bayes_pls_golite062009 |
| nucleic acid binding | 0.882469239828589 | bayes_pls_golite062009 |
| DNA binding | 0.762515260839252 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.58590430118616 | bayes_pls_golite062009 |
| transcription factor activity | 0.56681746573603 | bayes_pls_golite062009 |
| transcription activator activity | 0.488465624367016 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| peptidase activity | 0.36599510639344 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type II | 0.365530951355731 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.34434685718027 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.33253160432275 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| PTB domain binding | 0.216691319543711 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.150740450460731 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| peptidase activity, acting on L-amino acid peptides | 0.0805828560158752 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.0123645889643007 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
| SH2 domain binding | 2.96656737540424E-4 | bayes_pls_golite062009 |
