Protein Overview: cnp1

General Information:
Name(s) found:	cnp1 / SPBC1105.17 [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	gi\|7630185\|dbj\|BAA94760.1\| CENP-A-like protein SpCENP-A [Schizosaccharomyces pombe] [NCBI NR] pir\|\|T39294 probable histone h3 variant - fission yeast (Schizosaccharomyces pombe) [NCBI NR] gi\|5531479\|emb\|CAB50980.1\| centromere-specific histone H3 CENP-A [Schizosaccharomyces pombe] [NCBI NR] gi\|46396055\|sp\|Q9Y812.1\|CENPA_SCHPO RecName: Full=Histone H3-like centromeric protein cnp1; Short=Centromere protein 1; AltName: Full=CENP-A homolog; AltName: Full=Silencing in the middle of the centromere protein 2 [NCBI NR] gi\|19113265\|ref\|NP_596473.1\| CENP-A [Schizosaccharomyces pombe] [NCBI NR] CENP-A [Sanger Pombe] (Q9Y812) Centromere protein 1 (CENP-A homolog) (Centromere autoantigen A homolog) (Silencing in the middle of the centromere protein 2) [Swiss-Prot] Histone H3-like centromeric protein cnp1 OS=Schizosaccharomyces pombe GN=cnp1 PE=1 SV=1 [Swiss-Prot] INNER CENTROMERE PROTEIN; HISTONE H3 VARIANT; ESSENTIAL; REQUIRED FOR EQUAL CHROMOSOME SEGREGATION; SIMILAR TO S. CEREVISIAE CSE4: Q9Y812; [pompepVF.fasta] INNER CENTROMERE-SPECIFIC HISTONE H3 VARIANT ESSENTIAL FOR EQUAL CHROMOSOME SEGREGATION: Q9Y812; [pompepV13] Probable histone H3 variant (CENP-A-like protein SPCENP-A) [pompep4896] \|cnp1\|sim2\|inner centromere protein [pompepnew.fasta] Centromere protein 1 (CENP-A homolog) (Centromere autoantigen A homolog) (Silencing in the middle of the centromere protein 2) [4896.FASTAC] \|cnp1\|sim2\|histone H3 variant\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] probable histone h3 variant [Schizosaccharomyces pombe]gi\|5531479\|emb\|CAB50980.1\| SPBC1105.17 [Schizosaccharomyces pombe]gi\|46396055\|sp\|Q9Y812\|CNP1_SCHPO Centromere protein 1 (CENP-A homolog) (Centromere autoantigen A homolog) (Silencing in the middle o [nrdb_11152004_Chlamydomonas] \|cnp1\|sim2\|CENP-A-like protein\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] (Q9Y812) Probable histone H3 variant (CENP-A-like protein SPCENP-A) [pompep4896_normal_reversed] \|cnp1\|sim2\|centromere-specific histone H3 CENP-A\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] SPBC1105.17 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] CENP-A-like protein SpCENP-A [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPBC1105.17 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] \|cnp1\|sim2\|histone H3 variant CENP-A\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [spombe-190209-contam.fasta] Histone H3-like centromeric protein cnp1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cnp1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	120 amino acids
Gene Ontology:
Cellular Component:	centromere-specific nucleosome [NAS] nucleus [IC][IDA] inner kinetochore of condensed chromosome [IDA] condensed chromosome, centromeric region [IDA]
Biological Process:	chromatin silencing at centromere [IMP] centromeric heterochromatin formation [IMP] protein localization to kinetochore [IGI] mitotic sister chromatid segregation [IMP] sister chromatid biorientation [TAS] kinetochore assembly [TAS] nucleosome assembly [IEA]
Molecular Function:	protein binding [IGI][IPI] centromeric DNA binding [ISS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MAKKSLMAEP GDPIPRPRKK RYRPGTTALR EIRKYQRSTD LLIQRLPFSR IVREISSEFV 60 61 ANFSTDVGLR WQSTALQCLQ EAAEAFLVHL FEDTNLCAIH AKRVTIMQRD MQLARRIRGA 120 121

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..120]	PSI-BLAST	45.39794	Histone H3

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	4.57339366278729	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
centromeric DNA binding	2.60445660474495	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.38228606466152	bayes_pls_golite062009
transcription repressor activity	2.3574713307436	bayes_pls_golite062009
transcription corepressor activity	1.30859203490073	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
protein binding	1.07873333188144	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
transcription initiation factor activity	0.725138319268162	bayes_pls_golite062009
histone binding	0.218942897869955	bayes_pls_golite062009
transcription coactivator activity	0.0885263144317296	bayes_pls_golite062009
sequence-specific DNA binding	0.0852726470007639	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle