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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A macromolecular complex containing both protein and DNA molecules. A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. The ordered and organized complex of DNA and protein that forms the chromosome. The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: centromere-specific nucleosome
Acc: GO:0043505
Aspect: Cellular Component
Desc: A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).
Synonyms:
  • centromeric nucleosome
  • centromere specific nucleosome
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043505 - centromere-specific nucleosome (interactive image map)

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