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Protein Overview: SPAC186.09

General Information:
Name(s) found: SPAC186.09 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • pyruvate decarboxylase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: cellular amino acid catabolic process [ISS]
    generation of precursor metabolites and energy [NAS]
    pyruvate metabolic process [ISSLink to PubMed article]
    Molecular Function: magnesium ion binding [IEA]
    thiamin pyrophosphate binding [IEA]
    pyruvate decarboxylase activity [ISSLink to PubMed article]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDNQQAVQL QQPTTIGHYL AVRLAQAGVK HHFVVPGDYN LGLLDKLQYN NYLEEVNCAN  60
   61 ELNCAFAAEG YARANGIAAC VVTYSVGAFT AFDGIGGAYA EDLPVILISG SPNTNDIGSS 120
  121 HLLHHTLGTH DFSYQYEMAK KITCAAVSIQ RPTEAPRLID YAIKMALLKK KPVYIEVPTN 180
  181 VASQPCAAPG PASLITEPET SNQEYLQMAV DISAKIVNGK QKPVLLAGPK LRSFKAESAF 240
  241 LELANSLNCS VAVMPNAKSF FPESHPNYAG IYWGQASTLG AESIINWSDC IICAGTTFTD 300
  301 YSSNGWTSLP PKANVLHVDV DRVTVSDAEF GGVLLRDFLH ELAKKVKANN ASVVEYKRIR 360
  361 PESLEIPMEN PKAALNRKEI IRQVQNLVNQ ETTLFVDTGD SWFGGMRITL PEKARFEIEM 420
  421 QWGHIGWSVP SAFGYAIGAP KRNVVVFVGD GSFQETVQEV SQMVRLNLPI IMFLINNRGY 480
  481 TIEVEIHDGP YNRIKNWDYA AIVEAFNAGE GHAKGFRVGN GHELAEAIRQ AKENSQGPTL 540
  541 IECNIDQDDC SKELINWGHN VGAANGKPPA KE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..572] PSI-BLAST 96.69897 Pyruvate decarboxylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  12.903449876837 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  12.3239025230705 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  5.28857071459273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.21233670052586 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  5.08663245333808 bayes_pls_golite062009
  • NAD or NADH binding
    		•  3.93430700665136 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.15444163802756 bayes_pls_golite062009
  • transketolase activity
    		•  2.13705987575498 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  2.09493047697397 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  2.09493047697397 bayes_pls_golite062009
  • histone deacetylase activity
    		•  2.07818242335598 bayes_pls_golite062009
  • protein deacetylase activity
    		•  2.07076853700185 bayes_pls_golite062009
  • deoxyhypusine synthase activity
    		•  2.04735838056767 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.98546381612935 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.82969293063325 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • deacetylase activity
    		•  1.21596867135219 bayes_pls_golite062009
  • binding
    		•  1.17940168894417 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • phenylpyruvate decarboxylase activity
    		•  1.11553401986553 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  1.07090849835369 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.0611726850452 bayes_pls_golite062009
  • protein binding
    		•  0.992849906276347 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.78591260444574 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  0.750929351082237 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.614654207326026 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.51426028502998 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.492590326775569 bayes_pls_golite062009
  • transferase activity
    		•  0.413024577830522 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.40721151987565 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle