YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC186.09
Organism:	Schizosaccharomyces pombe
Length:	572 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC186.09.

Description	E-value	Query Range	Subject Range
gi\|71671664, gi\|... - gi\|71674688\|ref\|ZP_00672434.1\| Acetolactate synthase, large subunit, biosynthetic type [Trichodesmiu...	558.0	[0..4]	[572..2]
gi\|17232105, gi\|... - gi\|17232105\|ref\|NP_488653.1\| acetolactate synthase 3 catalytic subunit [Nostoc sp. PCC 7120], gi\|171... gi\|25291313 - pir\|\|AE2382 acetohydroxy acid synthase [imported] - Nostoc sp. (strain PCC 7120)	556.0	[0..8]	[568..27]
gi\|75908969, gi\|... - gi\|75908969\|ref\|YP_323265.1\| acetolactate synthase 3 catalytic subunit [Anabaena variabilis ATCC 294...	556.0	[0..8]	[568..27]
gi\|22295020, gi\|... - gi\|22298839\|ref\|NP_682086.1\| acetolactate synthase 3 catalytic subunit [Thermosynechococcus elongatu...	550.0	[0..12]	[571..1]
gi\|21226772, gi\|... - gi\|21226772\|ref\|NP_632694.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina mazei Go1], g...	547.0	[0..10]	[565..5]
gi\|7436698 - pir\|\|C70341 acetolactate synthase (EC 4.1.3.18) large chain - Aquifex aeolicus gi\|15605942, gi\|... - gi\|2983101\|gb\|AAC06706.1\| acetolactate synthase large subunit [Aquifex aeolicus VF5], gi\|15605942\|re...	546.0	[0..15]	[568..5]
gi\|152905 - gi\|152905\|gb\|AAA26594.1\| acetohydroxy acid synthase (AHAS) gi\|152905 - gi\|152905\|gb\|AAA26594.1\| acetohydroxy acid synthase (AHAS) [Arthrospira platensis]	545.0	[0..4]	[572..2]
gi\|68249831, gi\|... - gi\|68249831\|ref\|YP_248943.1\| acetolactate synthase 3 catalytic subunit [Haemophilus influenzae 86-02... gi\|144986629, gi... - gi\|145632973\|ref\|ZP_01788706.1\| acetolactate synthase III large subunit [Haemophilus influenzae 3655... gi\|53732850 - gi\|53732850\|ref\|ZP_00349598.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth... gi\|229845604, gi... - gi\|229845604\|ref\|ZP_04465730.1\| acetolactate synthase 3 catalytic subunit [Haemophilus influenzae 6P...	545.0	[0..12]	[572..2]
ILVI_HAEIN - Acetolactate synthase large subunit OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 ... ILVI_HAEIN - Acetolactate synthase large subunit OS=Haemophilus influenzae GN=ilvI PE=3 SV=1 gi\|145273548, gi... - gi\|145641734\|ref\|ZP_01797310.1\| acetolactate synthase III large subunit [Haemophilus influenzae R302... gi\|145641734 - gi\|145641734\|ref\|ZP_01797310.1\| acetolactate synthase III large subunit [Haemophilus influenzae R302...	545.0	[0..12]	[572..2]
gi\|42631583 - gi\|42631583\|ref\|ZP_00157121.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...	545.0	[0..12]	[572..2]

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Predicted Domain #1

Region A:
Residues: [1-572]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDNQQAVQL QQPTTIGHYL AVRLAQAGVK HHFVVPGDYN LGLLDKLQYN NYLEEVNCAN  60
   61 ELNCAFAAEG YARANGIAAC VVTYSVGAFT AFDGIGGAYA EDLPVILISG SPNTNDIGSS 120
  121 HLLHHTLGTH DFSYQYEMAK KITCAAVSIQ RPTEAPRLID YAIKMALLKK KPVYIEVPTN 180
  181 VASQPCAAPG PASLITEPET SNQEYLQMAV DISAKIVNGK QKPVLLAGPK LRSFKAESAF 240
  241 LELANSLNCS VAVMPNAKSF FPESHPNYAG IYWGQASTLG AESIINWSDC IICAGTTFTD 300
  301 YSSNGWTSLP PKANVLHVDV DRVTVSDAEF GGVLLRDFLH ELAKKVKANN ASVVEYKRIR 360
  361 PESLEIPMEN PKAALNRKEI IRQVQNLVNQ ETTLFVDTGD SWFGGMRITL PEKARFEIEM 420
  421 QWGHIGWSVP SAFGYAIGAP KRNVVVFVGD GSFQETVQEV SQMVRLNLPI IMFLINNRGY 480
  481 TIEVEIHDGP YNRIKNWDYA AIVEAFNAGE GHAKGFRVGN GHELAEAIRQ AKENSQGPTL 540
  541 IECNIDQDDC SKELINWGHN VGAANGKPPA KE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	96.69897
Match:	1zpdA
Description:	Pyruvate decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	12.903449876837	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	12.3239025230705	bayes_pls_golite062009
pyruvate dehydrogenase activity	5.28857071459273	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.21233670052586	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	5.08663245333808	bayes_pls_golite062009
NAD or NADH binding	3.93430700665136	bayes_pls_golite062009
transcription regulator activity	2.9155913558118	bayes_pls_golite062009
DNA binding	2.43141001866996	bayes_pls_golite062009
nucleic acid binding	2.41433477472968	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.15444163802756	bayes_pls_golite062009
transketolase activity	2.13705987575498	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	2.09493047697397	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	2.09493047697397	bayes_pls_golite062009
histone deacetylase activity	2.07818242335598	bayes_pls_golite062009
protein deacetylase activity	2.07076853700185	bayes_pls_golite062009
deoxyhypusine synthase activity	2.04735838056767	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.98546381612935	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.82969293063325	bayes_pls_golite062009
hydrolase activity	1.43067365161346	bayes_pls_golite062009
transcription factor activity	1.30143289828088	bayes_pls_golite062009
deacetylase activity	1.21596867135219	bayes_pls_golite062009
binding	1.17940168894417	bayes_pls_golite062009
transcription factor binding	1.14766678956419	bayes_pls_golite062009
phenylpyruvate decarboxylase activity	1.11553401986553	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	1.07090849835369	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.0611726850452	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
cation transmembrane transporter activity	0.78591260444574	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	0.750929351082237	bayes_pls_golite062009
transcription repressor activity	0.614654207326026	bayes_pls_golite062009
transcription cofactor activity	0.54005617175343	bayes_pls_golite062009
ion transmembrane transporter activity	0.51426028502998	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.492590326775569	bayes_pls_golite062009
transferase activity	0.413024577830522	bayes_pls_golite062009
transcription corepressor activity	0.40721151987565	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.114062221123972	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: