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Protein Overview: ctf18

General Information:
Name(s) found: ctf18 / SPBC902.02c [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • DNA replication factor C complex subunit Ctf18 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 960 amino acids

    Gene Ontology:
    Cellular Component: Ctf18 RFC-like complex [TASLink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear replication fork [IC]
    cytosol [IDALink to PubMed article]
    DNA replication factor C complex [ISSLink to PubMed article]
    Biological Process: attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [IMPLink to PubMed article]
    sister chromatid cohesion [TASLink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    DNA-dependent DNA replication [IC]
    Molecular Function: ATP binding [IEA]
    DNA clamp loader activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSIPNEDDL EKLLVAEQNV PYGKNYESFE DEENYLLELR NANALENLEH RSIPNDLFHS  60
   61 SQPVGSPTRN GDDIPSTLDL YSSDNAAIDT DISEDETINQ RHAPQTDYRY PNTSANPKMG 120
  121 LEESMDIDMP SIDLDISNAA AFPRDSNLLF RNYNSHTKTS EKGSPVNFEK ENQDSNVLFS 180
  181 TGRTSVLHID AEQSQTNNTV TPLKDDALSL FSFENDVNGA VNDNSLDQKL SASKNSQRVS 240
  241 LPFFSKIELD EGSSFSGPKI SARTSSGKII YFPKKKNRHS DGLLLQPKRL ADEISQVNEI 300
  301 GKDFNQDLLN SVRIWSENFL IVSKEKSVAL KTEKLDSLQI TNCTTKPQSQ KLWVDTYRPQ 360
  361 LFRDLLGDER VHRAAMHWIK AWDPCVFGKS RLQPSKSMRF NPRFTNITSD SDRPDKRIMM 420
  421 LTGLAGAGKT TLAHVIAHQA GYKVLEINAS DDRTAHTVHE KVSSAISNHS ALSSQPTCVI 480
  481 VDEIDGGDPA FVRALLSLLE SDEKATEYSQ AGNSKKKKKF KKLCRPIICI CNDLYTPALR 540
  541 PLRPYAQIIY FRPPPQASLV GRLRTICRNE NIAVDSRSLT LLTDIYNSDI RSCINSLQLL 600
  601 SLNNKRIDSE TIKLLQPKSN SFSTSSLIQS LFLQLDNKQI RAIEASQPTY SHLDALLARI 660
  661 DGANDSESVL MNCFHTYLDL PFTDSLLSKP ALTSEWLYFF DQLHSQCYKG NYELWRYIPY 720
  721 SIIHFHYLYA TPEKCRLPHP PRSDLEALKL YRTRKEILDS FISTLNAYEN QMHGERSILL 780
  781 ELIRTILITI NPTLKQKEDS MPRSALPSKI EHAINILNHY NLRFQQLPVG DGNYVYRLEP 840
  841 PLDELVWDAP TSSYSVRQML SQELLKKRLA DIKKQTLTDN PTSSNSSRKR KDFNSGKAIK 900
  901 RDFFGRIISE PKSEAVTSNN AALNTGDHPV SIKHAINIKF HDGFSNAVRK PISLNEILNF 960
  961

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..622] PSI-BLAST 67.30103 N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
    2 View Details [623..819] PSI-BLAST 56.69897 EDTA treated
    3 View Details [820..960] PSI-BLAST 84.0 VCP/p97

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  6.51495346697904 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  6.40748863504898 bayes_pls_golite062009
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.69246499202248 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.61582393123755 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.59641929642359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.59333672868803 bayes_pls_golite062009
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • transporter activity
    		•  2.17383908004663 bayes_pls_golite062009
  • ATPase activity
    		•  2.11122403732968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.02444700826552 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.8908019270286 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35268825531078 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.97700154207756 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.608058786636536 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.081265446432119 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle