YRC Public Data Repository - Protein Structure Prediction

Protein:	ctf18
Organism:	Schizosaccharomyces pombe
Length:	960 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ctf18.

Description	E-value	Query Range	Subject Range
gi\|27374245, gi\|... - gi\|27374245\|gb\|AAO01004.1\| CG2331-PA [Drosophila erecta], gi\|194858161\|ref\|XP_001969115.1\| TER94 [Dr...	328.0	[0..357]	[960..173]
TER94-PA - The gene TER94 is referred to in FlyBase by the symbol Dmel\TER94 (CG2331, FBgn0261014). It is a pro... gi\|220942716 - gi\|220942716\|gb\|ACL83901.1\| TER94-PA [synthetic construct]	327.0	[0..357]	[960..173]
gi\|83423461, gi\|... - gi\|95102992\|gb\|ABF51437.1\| transitional endoplasmic reticulum ATPase TER94 [Bombyx mori], gi\|8342346...	325.0	[0..357]	[960..174]
gi\|66534286 - gi\|66534286\|ref\|XP_392892.2\| PREDICTED: similar to TER94 CG2331-PA, isoform A isoform 1 [Apis mellif...	325.0	[0..357]	[960..173]
gi\|54635868, gi\|... - gi\|54635868\|gb\|EAL25271.1\| GA15351-PA [Drosophila pseudoobscura], gi\|125808288\|ref\|XP_001360696.1\| G...	324.0	[0..357]	[960..167]
gi\|58387543, gi\|... - gi\|58387543\|ref\|XP_315644.2\| ENSANGP00000022801 [Anopheles gambiae str. PEST], gi\|55238432\|gb\|EAA440...	323.0	[0..357]	[960..173]
gi\|91086235 - gi\|91086235\|ref\|XP_966692.1\| PREDICTED: similar to transitional endoplasmic reticulum ATPase TER94 i...	321.0	[0..357]	[960..174]
gi\|116000599 - gi\|116000599\|emb\|CAL50279.1\| putative transitional endoplasmic reticulum ATPase (ISS) [Ostreococcus ...	321.0	[0..372]	[960..233]
gi\|108873203, gi... - gi\|157126628\|ref\|XP_001654680.1\| spermatogenesis associated factor [Aedes aegypti], gi\|108873203\|gb\|...	319.0	[0..357]	[960..173]

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Predicted Domain #1

Region A:
Residues: [1-622]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSIPNEDDL EKLLVAEQNV PYGKNYESFE DEENYLLELR NANALENLEH RSIPNDLFHS  60
   61 SQPVGSPTRN GDDIPSTLDL YSSDNAAIDT DISEDETINQ RHAPQTDYRY PNTSANPKMG 120
  121 LEESMDIDMP SIDLDISNAA AFPRDSNLLF RNYNSHTKTS EKGSPVNFEK ENQDSNVLFS 180
  181 TGRTSVLHID AEQSQTNNTV TPLKDDALSL FSFENDVNGA VNDNSLDQKL SASKNSQRVS 240
  241 LPFFSKIELD EGSSFSGPKI SARTSSGKII YFPKKKNRHS DGLLLQPKRL ADEISQVNEI 300
  301 GKDFNQDLLN SVRIWSENFL IVSKEKSVAL KTEKLDSLQI TNCTTKPQSQ KLWVDTYRPQ 360
  361 LFRDLLGDER VHRAAMHWIK AWDPCVFGKS RLQPSKSMRF NPRFTNITSD SDRPDKRIMM 420
  421 LTGLAGAGKT TLAHVIAHQA GYKVLEINAS DDRTAHTVHE KVSSAISNHS ALSSQPTCVI 480
  481 VDEIDGGDPA FVRALLSLLE SDEKATEYSQ AGNSKKKKKF KKLCRPIICI CNDLYTPALR 540
  541 PLRPYAQIIY FRPPPQASLV GRLRTICRNE NIAVDSRSLT LLTDIYNSDI RSCINSLQLL 600
  601 SLNNKRIDSE TIKLLQPKSN SF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.30103
Match:	1ksfX
Description:	N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA clamp loader activity	6.51495346697904	bayes_pls_golite062009
protein-DNA loading ATPase activity	6.40748863504898	bayes_pls_golite062009
motor activity	2.79327761685782	bayes_pls_golite062009
microtubule motor activity	2.74365461017633	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.69246499202248	bayes_pls_golite062009
pyrophosphatase activity	2.61582393123755	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.59641929642359	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.59333672868803	bayes_pls_golite062009
binding	2.44689197844883	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
transporter activity	2.17383908004663	bayes_pls_golite062009
ATPase activity	2.11122403732968	bayes_pls_golite062009
transmembrane transporter activity	2.02444700826552	bayes_pls_golite062009
ATPase activity, coupled	1.8908019270286	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
cytoskeletal protein binding	1.40488517180956	bayes_pls_golite062009
hydrolase activity	1.35268825531078	bayes_pls_golite062009
structure-specific DNA binding	1.2539059700735	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
double-stranded DNA binding	1.117585097627	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
tubulin binding	0.979946830272106	bayes_pls_golite062009
substrate-specific transporter activity	0.97700154207756	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
microtubule binding	0.907162506177187	bayes_pls_golite062009
actin binding	0.883285269827407	bayes_pls_golite062009
transcription regulator activity	0.748437190903548	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.608058786636536	bayes_pls_golite062009
single-stranded DNA binding	0.568457189190858	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
guanyl nucleotide binding	0.399434758448606	bayes_pls_golite062009
GTP binding	0.398333597279278	bayes_pls_golite062009
guanyl ribonucleotide binding	0.39332178627529	bayes_pls_golite062009
mismatched DNA binding	0.31144582840038	bayes_pls_golite062009
four-way junction helicase activity	0.26252931460003	bayes_pls_golite062009
ATP binding	0.19169045543599	bayes_pls_golite062009
exodeoxyribonuclease V activity	0.185603938981231	bayes_pls_golite062009
protein transporter activity	0.178442534411253	bayes_pls_golite062009
adenyl ribonucleotide binding	0.165732470448462	bayes_pls_golite062009
adenyl nucleotide binding	0.162060759063149	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
structural constituent of ribosome	0.089234257580272	bayes_pls_golite062009
ion transmembrane transporter activity	0.081265446432119	bayes_pls_golite062009
3'-5' DNA helicase activity	0.0769112340058804	bayes_pls_golite062009
protein binding	0.071010918255742	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [623-819]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSSLIQSLF LQLDNKQIRA IEASQPTYSH LDALLARIDG ANDSESVLMN CFHTYLDLPF  60
   61 TDSLLSKPAL TSEWLYFFDQ LHSQCYKGNY ELWRYIPYSI IHFHYLYATP EKCRLPHPPR 120
  121 SDLEALKLYR TRKEILDSFI STLNAYENQM HGERSILLEL IRTILITINP TLKQKEDSMP 180
  181 RSALPSKIEH AINILNH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	2ce7A
Description:	EDTA treated
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [820-960]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNLRFQQLPV GDGNYVYRLE PPLDELVWDA PTSSYSVRQM LSQELLKKRL ADIKKQTLTD  60
   61 NPTSSNSSRK RKDFNSGKAI KRDFFGRIIS EPKSEAVTSN NAALNTGDHP VSIKHAINIK 120
  121 FHDGFSNAVR KPISLNEILN F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.0
Match:	1oz4A
Description:	VCP/p97
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: