Protein Overview: imp1

General Information:
Name(s) found:	imp1 / SPBC1604.08c [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	pir\|\|T39506 importin alpha subunit - fission yeast (Schizosaccharomyces pombe) [NCBI NR] gi\|74627009\|sp\|O94374.1\|IMA2_SCHPO RecName: Full=Importin subunit alpha-2; AltName: Full=Karyopherin subunit alpha-2; AltName: Full=Importin-1 [NCBI NR] gi\|4007760\|emb\|CAA22341.1\| importin alpha [Schizosaccharomyces pombe] [NCBI NR] gi\|19113424\|ref\|NP_596632.1\| importin alpha [Schizosaccharomyces pombe] [NCBI NR] importin alpha [Sanger Pombe] Importin subunit alpha-2 OS=Schizosaccharomyces pombe GN=imp1 PE=1 SV=1 [Swiss-Prot] IMPORTIN ALPHA SUBUNIT: O94374; [pompepVF.fasta] Putative importin alpha subunit [pompep4896] \|imp1\|\|putative importin alpha subunit [pompepnew.fasta] Imp1 protein (Spbc1604.08c protein) [4896.FASTAC] \|imp1\|\|karyopherin (predicted)\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] SPBC1604.08c [Schizosaccharomyces pombe]gi\|19113424\|ref\|NP_596632.1\| importin alpha subunit [Schizosaccharomyces pombe]gi\|7492102\|pir\|\|T39506 importin alpha subunit - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas] \|imp1\|\|karyopherin \|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] (O94374) Putative importin alpha subunit [pompep4896_normal_reversed] \|imp1\|\|importin alpha\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] SPBC1604.08c [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPBC1604.08c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] Importin subunit alpha-2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=imp1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	539 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] nucleus [IDA ] cytosol [IDA] nucleolus [IDA] nuclear pore [TAS]
Biological Process:	nucleocytoplasmic transport [TAS] M phase of mitotic cell cycle [IMP] establishment of nucleus localization [IMP] NLS-bearing substrate import into nucleus [IDA] cellular response to stress [IGI] regulation of mitotic cell cycle [IMP]
Molecular Function:	GTP binding [NAS] protein binding [IPI] protein transporter activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESRYLSDRR SRFKSKGVFK ADELRRQREE QQIEIRKQKR EESLNKRRNL NAVLQNDIDV  60
   61 EEEADQSQVQ MEQQMKDEFP KLTADVMSDD IELQLGAVTK FRKYLSKETH PPIDQVIACG 120
  121 VVDRFVQFLE SEHHLLQFEA AWALTNIASG TTDQTRIVVD SGAVPRFIQL LSSPEKDVRE 180
  181 QVVWALGNIA GDSSACRDYV LGNGVLQPLL NILQSSASDV SMLRNATWTL SNLCRGKNPP 240
  241 PNWSTISVAV PILAKLLYSE DVEIIVDACW AISYLSDGPN EKIGAILDVG CAPRLVELLS 300
  301 SPSVNIQTPA LRSVGNIVTG TDAQTQIIID CGALNAFPSL LSHQKENIRK EACWTISNIT 360
  361 AGNTQQIQAI IESNLIPPLV HLLSYADYKT KKEACWAISN ATSGGLGQPD QIRYLVSQGV 420
  421 IKPLCDMLNG SDNKIIQVAL DAIENILKVG EMDRTMDLEN INQYAVYVEE AGGMDMIHDL 480
  481 QSSGNNDIYL KAYSIIEKYF SDEDAVEDLA PETENGAFTF GNGPQAQGEF KFDSQDMAM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
nuclear export signal receptor activity	3.48172991171337	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
actin binding	2.8014924948341	bayes_pls_golite062009
nucleic acid binding	2.74745843355294	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
DNA binding	1.95242774903625	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
molecular transducer activity	1.32874350341969	bayes_pls_golite062009
signal transducer activity	1.32874350341969	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
transcription factor activity	1.20660383756339	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
structural molecule activity	0.279926218252647	bayes_pls_golite062009
importin-alpha export receptor activity	0.259676026705859	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..539]	PSI-BLAST	90.522879	Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP

Protein Overview: imp1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: