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Protein Overview: brl2

General Information:
Name(s) found: brl2 / SPCC970.10c [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • ubiquitin-protein ligase E3 Brl2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 680 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    HULC complex [IDALink to PubMed articleLink to PubMed article]
    centromeric heterochromatin [IDALink to PubMed article]
    Biological Process: chromatin assembly [IMPLink to PubMed article]
    DNA replication-independent nucleosome assembly [TASLink to PubMed article]
    histone H2B ubiquitination [IDALink to PubMed article][IMPLink to PubMed article]
    histone H3-K4 methylation [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IEPLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article][ISSLink to PubMed article]
    zinc ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQNGKPDAP TILGQKRELE DVEIQDDDIQ EVSKEDLLKD VRVRSIQFDE LESKIEGLQN  60
   61 LAEEKLKVLA TLVSWWPEIL QQFSVVFQGN ELKDFESEGV FSILEKFPEL SYFNDAVKNN 120
  121 KTKALSIIQK LLSTVDSSTN SVSRDPFSVL SIDDSALTEK LNTINLDIDK ILDELDTTRS 180
  181 QLHSIIKLPD RSSSFTLQCI NESVRPQSTK VKEEATTSSK GKDEEKKVST VEQRTQLQQL 240
  241 SRLQDQQNGL MESRSQSLKI LDSNVNEMDK LIMERENALN NVETTNLKKY SSFLALKEAV 300
  301 SMTSEQLRVL EHLLSECSHE INVLSQQSKN FNGVFESSYQ PLINDLDHQI SVMQNDEKRI 360
  361 NNAKTELSLS LEKKLEAKKQ KEKVYKDKLD ELANLETMVL EKKKAVATRE AANKIRLVDL 420
  421 NDLELQKDLS TYLSKELAST EKAFRLVKQQ TVKSSHSHYQ ELITKFSVEK EKAEQKYFLT 480
  481 MKSTDSLHAE VKLLRQKYQK TNEIISKMLN SQDTAVHRII EFEDQLARLS SVRNNSIKQS 540
  541 TTFQVKKSSQ KSTIQNLEEK VSYLQQFMDK NNATLTDLEF QCSDLSSSID ILSKQDEEHE 600
  601 KEKRKLKDTG VSTSAEELKT FRAMCKCSVC NFERWKDRII SLCGHGFCYQ CIQKRIETRQ 660
  661 RRCPICGRGF GASDVIPIHL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..326] PSI-BLAST 18.30103 Heavy meromyosin subfragment
    2 View Details [327..589] PSI-BLAST 10.522879 Tropomyosin
    3 View Details [590..680] PSI-BLAST 5.0 Eea1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  6.59529767480757 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.83903906079477 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.99298545019925 bayes_pls_golite062009
  • histone binding
    		•  3.01402804224903 bayes_pls_golite062009
  • binding
    		•  2.93415748500038 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.89424169822343 bayes_pls_golite062009
  • DNA binding
    		•  2.67786232715949 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.6327300364647 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.02130427551376 bayes_pls_golite062009
  • methylated histone residue binding
    		•  1.80051107279585 bayes_pls_golite062009
  • ligase activity
    		•  1.77568859874674 bayes_pls_golite062009
  • transcription factor activity
    		•  1.62385700361588 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.49667541832007 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.49585178848749 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.49585178848749 bayes_pls_golite062009
  • protein binding
    		•  1.42349040268084 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.3339105639569 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.3339105639569 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.3339105639569 bayes_pls_golite062009
  • chromatin binding
    		•  1.04248905371583 bayes_pls_golite062009
  • deacetylase activity
    		•  0.930628753249637 bayes_pls_golite062009
  • transcription activator activity
    		•  0.739132967687069 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.507152521861549 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.499452745852361 bayes_pls_golite062009
  • protein kinase activity
    		•  0.405766438875014 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.327424740985033 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.194167864611162 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.14235705491362 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.137650352572163 bayes_pls_golite062009
  • nucleosome binding
    		•  0.113716463693321 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0901653273812402 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0725773086825168 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.0593271945476304 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0538806851320555 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.0258084204536424 bayes_pls_golite062009
  • kinase activity
    		•  0.00387875923819597 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle