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View Structure Prediction Details

Protein: brl2
Organism: Schizosaccharomyces pombe
Length: 680 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for brl2.

Description E-value Query
Range
Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
276.0 [0..4] [642..1862]
MYH4_MOUSE - Myosin-4 OS=Mus musculus GN=Myh4 PE=2 SV=1
236.0 [0..2] [642..860]
MYH4_RAT - Myosin-4 OS=Rattus norvegicus GN=Myh4 PE=1 SV=1
235.0 [0..2] [642..860]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
235.0 [0..2] [642..858]
MYH1_HORSE - Myosin-1 OS=Equus caballus GN=MYH1 PE=2 SV=1
234.0 [0..2] [642..859]
MYSS_CYPCA - Myosin heavy chain, fast skeletal muscle OS=Cyprinus carpio PE=2 SV=2
234.0 [0..2] [642..857]
gi|165973992, gi... - gi|83026762|gb|ABB96408.1| fast myosin heavy chain 2X [Canis familiaris], gi|165973992|ref|NP_001107...
233.0 [0..2] [642..874]
gi|55742224, gi|... - gi|55742224|ref|NP_001006915.1| myosin, heavy polypeptide 2, skeletal muscle, adult [Xenopus (Silura...
gi|55742224 - ref|NP_001006915.1| myosin, heavy polypeptide 2, skeletal muscle, adult [Xenopus tropicalis]
233.0 [0..2] [642..856]

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Predicted Domain #1
Region A:
Residues: [1-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQNGKPDAP TILGQKRELE DVEIQDDDIQ EVSKEDLLKD VRVRSIQFDE LESKIEGLQN  60
   61 LAEEKLKVLA TLVSWWPEIL QQFSVVFQGN ELKDFESEGV FSILEKFPEL SYFNDAVKNN 120
  121 KTKALSIIQK LLSTVDSSTN SVSRDPFSVL SIDDSALTEK LNTINLDIDK ILDELDTTRS 180
  181 QLHSIIKLPD RSSSFTLQCI NESVRPQSTK VKEEATTSSK GKDEEKKVST VEQRTQLQQL 240
  241 SRLQDQQNGL MESRSQSLKI LDSNVNEMDK LIMERENALN NVETTNLKKY SSFLALKEAV 300
  301 SMTSEQLRVL EHLLSECSHE INVLSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [327-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSKNFNGVFE SSYQPLINDL DHQISVMQND EKRINNAKTE LSLSLEKKLE AKKQKEKVYK  60
   61 DKLDELANLE TMVLEKKKAV ATREAANKIR LVDLNDLELQ KDLSTYLSKE LASTEKAFRL 120
  121 VKQQTVKSSH SHYQELITKF SVEKEKAEQK YFLTMKSTDS LHAEVKLLRQ KYQKTNEIIS 180
  181 KMLNSQDTAV HRIIEFEDQL ARLSSVRNNS IKQSTTFQVK KSSQKSTIQN LEEKVSYLQQ 240
  241 FMDKNNATLT DLEFQCSDLS SSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [590-680]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DILSKQDEEH EKEKRKLKDT GVSTSAEELK TFRAMCKCSV CNFERWKDRI ISLCGHGFCY  60
   61 QCIQKRIETR QRRCPICGRG FGASDVIPIH L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1hyiA
Description: Eea1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 6.59529767480757 bayes_pls_golite062009
acid-amino acid ligase activity 5.83903906079477 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.99298545019925 bayes_pls_golite062009
histone binding 3.01402804224903 bayes_pls_golite062009
binding 2.93415748500038 bayes_pls_golite062009
transcription regulator activity 2.89424169822343 bayes_pls_golite062009
DNA binding 2.67786232715949 bayes_pls_golite062009
nucleic acid binding 2.6327300364647 bayes_pls_golite062009
histone methyltransferase activity 2.02130427551376 bayes_pls_golite062009
methylated histone residue binding 1.80051107279585 bayes_pls_golite062009
ligase activity 1.77568859874674 bayes_pls_golite062009
transcription factor activity 1.62385700361588 bayes_pls_golite062009
protein methyltransferase activity 1.49667541832007 bayes_pls_golite062009
histone acetyltransferase activity 1.49585178848749 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.49585178848749 bayes_pls_golite062009
protein binding 1.42349040268084 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.3339105639569 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.3339105639569 bayes_pls_golite062009
lysine N-methyltransferase activity 1.3339105639569 bayes_pls_golite062009
chromatin binding 1.04248905371583 bayes_pls_golite062009
deacetylase activity 0.930628753249637 bayes_pls_golite062009
transcription activator activity 0.739132967687069 bayes_pls_golite062009
transcription repressor activity 0.507152521861549 bayes_pls_golite062009
N-acetyltransferase activity 0.499452745852361 bayes_pls_golite062009
protein kinase activity 0.405766438875014 bayes_pls_golite062009
cytoskeletal protein binding 0.327424740985033 bayes_pls_golite062009
N-acyltransferase activity 0.194167864611162 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.14235705491362 bayes_pls_golite062009
N-methyltransferase activity 0.137650352572163 bayes_pls_golite062009
nucleosome binding 0.113716463693321 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0901653273812402 bayes_pls_golite062009
sequence-specific DNA binding 0.0725773086825168 bayes_pls_golite062009
protein deacetylase activity 0.0593271945476304 bayes_pls_golite062009
transcription factor binding 0.0538806851320555 bayes_pls_golite062009
histone deacetylase activity 0.0258084204536424 bayes_pls_golite062009
kinase activity 0.00387875923819597 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle